The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Systematic prevention of bubble formation and accumulation for long-term culture of pancreatic islet cells in microfluidic device
Open accessAbstract
Reliable long-term cell culture in microfluidic system is limited by air bubble formation and accumulation. In this study, we developed a bubble removal system capable of both trapping and discharging air bubbles in a consistent and reliable manner. Combined with PDMS (Polydimethylsiloxane) hydrophilic surface treatment and vacuum filling, a microfluidic perifusion system equipped with the bubble trap was successfully applied for long-term culture of mouse pancreatic islets with no bubble formation and no flow interruption. In addition to demonstrating normal cell viability and islet morphology, post-cultured islets exhibited normal insulin secretion kinetics, intracellular calcium signaling, and changes in mitochondrial potentials in response to glucose challenge. This design could be easily adapted by other microfluidic systems due to its simple design, ease of fabrication, and portability.
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Leak tightness and absence of bubbles are the main failure causes of microfluidic systems.
“Particular care should be given to the leak tightness and the absence of bubbles since these are the main failure causes of microfluidic systems (Leung et al., 2022; Wang et al., 2012).”
From Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility (2024) · cites this paper as Wang et al., 2012
The Introduction calls bubble formation and accumulation a critical obstacle in microfluidic applications and says bubbles can impair device performance. It does not identify leaks as a failure cause or establish that leaks and bubbles together are the main causes of microfluidic-system failure. (LLM, conf=0.87)
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Metadata
- Authors
- Wang, Y., Lee, D., Zhang, L., Jeon, H., Mendoza-Elias, J. E., Harvat, T. A., Hassan, S. Z., Zhou, A., Eddington, D. T., & Oberholzer, J.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Oberholzer, José
- ORCID
- Venue
- Biomedical Microdevices
- Published
- 2012-01-18
- Volume
- 14
- Issue
- 2
- Pages
- 419-426
- ISSN
- 1387-2176 (ISSN-L)
- 1572-8781
- PMC
- PMC3303988
- OpenAlex
- W1986681896
- Cited by
- 63
- References
- 21
- Citations by year
- 2024: 11 · 2023: 8 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Biomedical Microdevices (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Illinois at Chicago
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK091526)
- National Center for Research Resources (U42RR023245)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Physical Sciences › Chemical Engineering › Fluid Flow and Transfer Processes › Innovative Microfluidic and Catalytic Techniques Innovation
- Keywords
- air bubble removal, bubble trapping, bubble accumulation, long-term cell culture, pancreatic islets, vacuum filling, insulin secretion, intracellular calcium signaling, mitochondrial membrane potential, glycemic response
- MeSH terms
- Insulin Secretion, Animals, Cell Survival, Dimethylpolysiloxanes, Equipment Design, Glucose, Insulin, Islets of Langerhans, Mice, Inbred C57BL, Cell Culture Techniques, Microfluidics, Microfluidic Analytical Techniques, Mice
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