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Cited by 243MRI in cancer diagnosisBreast Lesions and CarcinomasBreast Cancer Treatment Studies

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Meta-analysis of pre-operative magnetic resonance imaging (MRI) and surgical treatment for breast cancer

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Houssami, Nehmat, Turner, Robin M., Morrow, Monica·2017·Breast Cancer Research and Treatment
DOI 10.1007/s10549-017-4324-3PMC PMC5580248
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Abstract

Background Although there is no consensus on whether pre-operative MRI in women with breast cancer (BC) benefits surgical treatment, MRI continues to be used pre-operatively in practice. This meta-analysis examines the association between pre-operative MRI and surgical outcomes in BC.Methods A systematic review was performed to identify studies reporting quantitative data on pre-operative MRI and surgical outcomes (without restriction by type of surgery received or type of BC) and using a controlled design. Random-effects logistic regression calculated the pooled odds ratio (OR) for each surgical outcome (MRI vs. no-MRI groups), and estimated ORs stratified by study-level age. Subgroup analysis was performed for invasive lobular cancer (ILC).Results Nineteen studies met eligibility criteria: 3 RCTs and 16 comparative studies that included newly diagnosed BC of any type except for three studies restricted to ILC. Primary analysis (85,975 subjects) showed that pre-operative MRI was associated with increased odds of receiving mastectomy [OR 1.39 (1.23, 1.57); p < 0.001]; similar findings were shown in analyses stratified by study-level median age. Secondary analyses did not find statistical evidence of an effect of MRI on the rates of re-excision, re-operation, or positive margins; however, MRI was significantly associated with increased odds of receiving contralateral prophylactic mastectomy [OR 1.91 (1.25, 2.91); p = 0.003]. Subgroup analysis for ILC did not find any association between MRI and the odds of receiving mastectomy [OR 1.00 (0.75, 1.33); p = 0.988] or the odds of re-excision [OR 0.65 (0.35, 1.24); p = 0.192].Conclusions Pre-operative MRI is associated with increased odds of receiving ipsilateral mastectomy and contralateral prophylactic mastectomy as surgical treatment in newly diagnosed BC patients.

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Metadata

Authors
Houssami, N., Turner, R. M., & Morrow, M.
Affiliations
  • The University of Sydney (AU)
  • UNSW Sydney (AU)
  • Memorial Sloan Kettering Cancer Center (US)
Corresponding author
Houssami, Nehmat
ORCID
Venue
Breast Cancer Research and Treatment
Publisher
Springer Science and Business Media LLC
Published
2017-06-06
Volume
165
Issue
2
Pages
273-283
ISSN
  • 0167-6806 (ISSN-L)
  • 1573-7217
DOI
10.1007/s10549-017-4324-3
PMC
PMC5580248
OpenAlex
W2622061173
Cited by
243
References
47
Citations by year
2026: 21 · 2025: 21 · 2024: 19 · 2023: 49 · 2022: 28 · 2021: 37 · 2020: 30 · 2019: 22 · 2018: 13 · 2017: 2
FWCI
2.77
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (unspecified)
Locations
  • Breast Cancer Research and Treatment (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • The Sydney eScholarship Repository (The University of Sydney) (submittedVersion)
Funders
National Cancer Institute (P30CA008748)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Keywords
breast cancer surgery, mastectomy, contralateral prophylactic mastectomy, re-excision, surgical outcomes, invasive lobular carcinoma, newly diagnosed breast cancer
MeSH terms
Breast Neoplasms, Female, Humans, Magnetic Resonance Imaging, Mastectomy, Preoperative Care, Prognosis, Reoperation, Mastectomy, Segmental, Odds Ratio, Treatment Outcome

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