Aromatase inhibitors and contralateral breast cancer in BRCA mutation carriers

Nemati Shafaee, Maryam; Goutsouliak, Kristina; Lin, Heather; Bevers, Therese B.; Gutierrez-Barrera, Angelica; Bondy, Melissa; Arun, Banu

doi:10.1007/s10549-022-06688-z

Aromatase inhibitors and contralateral breast cancer in BRCA mutation carriers

Background Deleterious BRCA mutations confer a significant lifetime risk of breast cancer (BC) as well as contralateral BC (CBC) in patients who do not undergo prophylactic mastectomy. Prior reports have suggested that tamoxifen reduces the risk of CBC in BRCA mutation carriers. Whether aromatase…