A portable device for measuring donor corneal transparency in eye banks
Abstract
To develop a portable device for measuring the donor corneal transparency and validate its efficacy for corneal evaluation in the eye-banks and for research. The transparency device (TD) has a light source, a detachable system for corneal insertion and a base for light transmission. The probe detects the transmitted light which is measured by a lux-meter. A contact lens was set as 'control' to reduce the light scattering concern, an empty petri-plate as 'blank' and the cornea as 'sample'. Two experts and non-experts (masked) observed the corneas for subjective analysis which was then compared using the TD. The parameters observed were scars, foreign-body, stromal-deformities, folds, thickness and opacity which were then converted to a relative overall percentage by the observer. Twenty corneas were evaluated for correlation, five tissues to obtain standard-deviation and twenty-four pairs for a comparative study. Experts mimicked the eye-banks with long-term experience while non-experts mimicked the emerging eye-banks. Subjective values by the experts closely resembled the measurements by TD. The average correlation between the experts and the non-experts to TD was 0.985 and 0.960 respectively. TD showed higher reproducibility than experts followed by the non-experts. The comparative study showed that increase in thickness reduces the transparency. TD is portable, easy, efficient, maintains sterility and less expensive hence the emerging eye-banks and researchers can use to ra…
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The two most commonly used techniques to measure corneal transparency ex vivo are tungsten light-based or laser-based bench-top optical systems, or spectrophotometry.
“The two most commonly used techniques to measure corneal transparency ex vivo are tungsten light-based or laser-based bench-top optical systems (Farrell et al., 1973, Christens-Barry et al., 1996, Parekh et al., 2014), or spectrophotometry (Cejka et al., 2010, Doutch et al., 2008).”
From Corneal structure and transparency (2015) · cites this paper as Parekh et al., 2014
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Corneal structure and transparency
Meek, K. M., & Knupp, C. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.07.001 · Cited by 853 · see citing works
- Authors
- Parekh, M., Ferrari, S., Ruzza, A., Pugliese, M., Ponzin, D., & Salvalaio, G.
- Affiliations
- Veneto Eye Bank Foundation (IT)
- Corresponding author
- Parekh, Mohit
- Venue
- Cell and Tissue Banking
- Published
- 2013-04-27
- Volume
- 15
- Issue
- 1
- Pages
- 7-13
- ISSN
- 1389-9333 (ISSN-L)
- 1573-6814
- OpenAlex
- W2041405582
- Cited by
- 25
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 5 · 2018: 2 · 2017: 2 · 2015: 2 · 2014: 2 · 2013: 2
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell and Tissue Banking (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Funders
- Ögonfonden
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal surgery and disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Corneal Surgery and Treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ocular Surface and Contact Lens
- Keywords
- donor cornea, corneal transparency, eye bank, portable measurement system, optical transmittance, corneal opacity, corneal thickness, reproducibility
- MeSH terms
- Cornea, Eye Banks, Humans, Tissue Donors, Vision, Ocular, Corneal Transplantation
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