Cited by 326Selenium in Biological SystemsHeavy Metal Exposure and ToxicityTrace Elements in Health

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Selenium interactions and toxicity: a review

Zwolak, Iwona, Zaporowska, Halina·2012·Cell Biology and Toxicology

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Abstract

Selenium is an essential trace element for mammals. Through selenoproteins, this mineral participates in various biological processes such as antioxidant defence, thyroid hormone production, and immune responses. Some reports indicate that a human organism deficient in selenium may be prone to certain diseases. Adverse health effects following selenium overexposure, although very rare, have been found in animals and people. Contrary to selenium, arsenic and cadmium are regarded as toxic elements. Both are environmental and industrial pollutants, and exposure to excessive amounts of arsenic or cadmium can pose a threat to many people's health, especially those living in polluted regions. Two other elements, vanadium and chromium(III) in trace amounts are believed to play essential physiological functions in mammals. This review summarizes recent studies on selenium interactions with arsenic and cadmium and selenium interactions with vanadium and chromium in mammals. Human studies have demonstrated that selenium may reduce arsenic accumulation in the organism and protect against arsenic-related skin lesions. Selenium was found to antagonise the prooxidant and genotoxic effects of arsenic in rodents and cell cultures. Also, studies on selenium effects against oxidative stress induced by cadmium in various animal tissues produced promising results. Reports suggest that selenium protection against toxicity of arsenic and cadmium is mediated via sequestration of these elements into biologically inert conjugates. Selenium-dependent antioxidant enzymes probably play a secondary role in arsenic and cadmium detoxification. So far, few studies have evaluated selenium effects on chromium(III) and vanadium actions in mammals. Still, they show that selenium may interact with these minerals. Taken together, the recent findings regarding selenium interaction with other elements extend our understanding of selenium biological functions and highlight selenium as a potential countermeasure against toxicity induced by arsenic and cadmium.

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Authors: Zwolak, I., & Zaporowska, H.
Affiliations: John Paul II Catholic University of Lublin (PL)
Corresponding author: Zwolak, Iwona
ORCID: Zwolak, Iwona
Venue: Cell Biology and Toxicology
Publisher: Springer Science and Business Media LLC
Published: 2011-09-14
Volume: 28
Issue: 1
Pages: 31-46
ISSN: 0742-2091 (ISSN-L)
1573-6822
DOI: 10.1007/s10565-011-9203-9
OpenAlex: W1959593972
Cited by: 325
References: 120
Citations by year: 2026: 18 · 2025: 26 · 2024: 22 · 2023: 21 · 2022: 23 · 2021: 33 · 2020: 28 · 2019: 32 · 2018: 16 · 2017: 20 · 2016: 19 · 2015: 22 · 2014: 22 · 2013: 14 · 2012: 8
FWCI: 1.74
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Cell Biology and Toxicology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: selenium, arsenic, cadmium, vanadium, trivalent chromium, trace element interactions, metal toxicity, arsenic accumulation, oxidative stress, antioxidant enzymes, metal detoxification, selenoproteins, genotoxicity, pro-oxidant activity
MeSH terms: Animals, Antioxidants, Arsenic, Cadmium, Chromium, Drug Interactions, Humans, Inactivation, Metabolic, Selenium, Trace Elements, Vanadium, Selenoproteins

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