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Anxiety Disorders in Children and Adolescents with Autistic Spectrum Disorders: A Meta-Analysis
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There is considerable evidence that children and adolescents with autistic spectrum disorders (ASD) are at increased risk of anxiety and anxiety disorders. However, it is less clear which of the specific DSM-IV anxiety disorders occur most in this population. The present study used meta-analytic techniques to help clarify this issue. A systematic review of the literature identified 31 studies involving 2,121 young people (aged <18 years) with ASD, and where the presence of anxiety disorder was assessed using standardized questionnaires or diagnostic interviews. Across studies, 39.6% of young people with ASD had at least one comorbid DSM-IV anxiety disorder, the most frequent being specific phobia (29.8%) followed by OCD (17.4%) and social anxiety disorder (16.6%). Associations were found between the specific anxiety disorders and ASD subtype, age, IQ, and assessment method (questionnaire versus interview). Implications for the identification and treatment of anxiety in young people with ASD are discussed.
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“Specific phobia (29%), obsessive–compulsive disorder (OCD) (17.4%), and social anxiety disorder (16.6%) were the three most commonly observed anxiety disorders in ASD youth [94].”
From Pharmacological treatment in autism: a proposal for guidelines on common co-occurring psychiatric symptoms (2025) · cites this paper as [94]
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“Approximately 20% of children under 6 years and 40% of children ages 6 to 18 years with ASD have one or more anxiety disorders [45, 47].”
From DINOSAUR: an integrated cognitive-behavioral treatment for anxiety in young children with ASD (2021) · cites this paper as [45]
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“Although prevalence estimates vary across studies, the current consensus is that 40%–50% of autistic individuals meet formal criteria for a co-occurring anxiety disorder (Buck et al., 2014; Van Steensel et al., 2011)”
From Self-guided mindfulness and cognitive behavioural practices reduce anxiety in autistic adults: A pilot 8-month waitlist-controlled trial of widely available online tools. (2020) · cites this paper as Van Steensel et al., 2011
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“Like ADHD, these other diagnoses are now recognized to occur commonly in individuals with ASD, including lifetime estimates for depression as high as 25% (Leyfer et al. 2006) and anxiety as high as 35% (van Steensel et al. 2011).”
From Recent Advances in Autism Research as Reflected in DSM-5 Criteria for Autism Spectrum Disorder (2015) · cites this paper as van Steensel et al. 2011
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“According to a meta-analysis, 39.6% of youth with ASD have at least one co-occurring anxiety disorder based on the DSM-IV criteria [71, 94].”
From Pharmacological treatment in autism: a proposal for guidelines on common co-occurring psychiatric symptoms (2025) · cites this paper as [94]
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BackgroundStuijfzand, S., Chakrabarti, B., Reynolds, S. A., & Dodd, H. F. (2019) · Behaviour Research and Therapy · doi:10.1016/j.brat.2019.103450 · Cited by 4
Pandolfi, V., & Magyar, C. I. (2015) · Autism and child psychopathology series · doi:10.1007/978-3-319-19183-6_7 · Cited by 4
Jain, N., Ahamed, S. I., Bozdag, S., Dolan, B. K., McVey, A. J., Willar, K. S., Pleiss, S. S., Murphy, C. C., Casnar, C. L., Potts, S., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/582676 · Cited by 4
Editorial: Antioxidants in Autism Spectrum Disorders
Bonomini, F., Siniscalco, D., Schultz, S. T., Carnovale, C., Barthélémy, C., & Fazzi, E. M. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.889865 · Cited by 4
Parenting Differences in Families With and Without Children on the Autism Spectrum
Yaffe, Y. (2025) · Springer eBooks · doi:10.1007/978-3-031-40858-8_454-1 · Cited by 4
Prasanna, N. V. T., & Nayak, M. (2024) · Discover Psychology · doi:10.1007/s44202-024-00311-6 · Cited by 3
“Various other factors, such as the type of anxiety disorder, the subtype of ASD, as well as the assessment methods, including age and IQ, play a role in exploring the interventions [27].”
Lieneman, C. C., Guastello, A. D., Munson, M. S., Barthle-Herrera, M. A., Bailey, B. A., Higham, M., Druskin, L. R., & McNeil, C. B. (2024) · Journal of Indian Association for Child and Adolescent Mental Health · doi:10.1177/09731342241252560 · Cited by 3
Öner, M., Lenker, K. P., & Durmus, D. (2025) · Building and Environment · doi:10.1016/j.buildenv.2025.113138 · Cited by 3
Hagen, A., Klein, A. M., Bögels, S. M., & van Steensel, F. J. A. (2025) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-025-06894-w · Cited by 3
“Children with ASD frequently experience anxiety disorders (Bougeard et al., 2021; Lai et al., 2019; Micai et al., 2023; van Steensel et al., 2011).”
Self-citationHomman, L. E., Augustine, L., & Granlund, M. (2025) · BMC Public Health · doi:10.1186/s12889-025-23388-7 · Cited by 7
“…of poor mental health are children with disabilities, not least those of a neurodevelopmental nature, as they have an on average higher levels of mental health problems and mental illness and lower level of mental health well-being in comparison to their peers without disabilities [14, 29, 30].”
Pathways to autism diagnosis in adulthood
Dufour, I., Chiu, Y. M., Brodeur, S., Courteau, M., Courteau, J., Dubé, E., LESAGE, A. D., Fombonne, E. J., & Couture, M. M. (2025) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-025-09627-3 · Cited by 4
Irritability in autism examined through network analysis of phenotypic and physiological correlates
Alatrash, S., Paul, T., Andrade, B. F., Monga, S., Brian, J. A., Anagnostou, E. A., Penner, M., Fekr, A. R., & Kushki, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-28408-5 · Cited by 4
“The features were also interconnected with anxiety which is a common, persistent, and disabling co-occurring condition in autistic individuals, affecting them across all levels of functioning and throughout their lifespan 65,66 .”
Zhang, L., 宋文坤, Gao, H., & Li, X. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1761833 · Cited by 3
“Epidemiological data indicate that 40% – 50% of individuals with ASD meet the clinical criteria for anxiety disorders, while comorbidity with attention-de fi cit/hyperactivity disorder (ADHD) ranges from 30% to 80% (2, 3).”
French, B., Newell, V., Nalbant, G., Wright, H., Daley, D., & Cassidy, S. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1702822 · Cited by 4
“Fourteen reviews (16, 33 – 38, 38 – 44) and ten mixed reviews (7, 8 Across mixed-topic reviews, prevalence estimates varied substantially (e.g., anxiety 1.47% – 54% in narrative reviews; 11.1% – 35% in meta-analyses) (8, 20, 22, 47).”
InfluentialTreatment of obsessive-compulsive disorder in a young person with autism spectrum disorder
Jassi, A. D., & Krebs, G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816563-8.00009-7 · Cited by 3
Interventions in ASD: Psychosocial Interventions and Supports for ASD
Brian, J. A., Smith, I. M., & Stover, K. (2023) · Springer eBooks · doi:10.1007/978-3-031-20792-1_21 · Cited by 3
Yang, W., Shi, Y., Li, J.-M., Gao, Y., Xu, Y., Tian, R., He, J.-J., Li, D.-H., Ding, Y., Xiao, L., et al. (2023) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2023.103541 · Cited by 3
Maggio, R., Turriziani, L., Campestre, C., Cara, M. D., Tripodi, E., Impallomeni, C., Quartarone, A., Passantino, C., & Cucinotta, F. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1225236 · Cited by 3
Salabura, C., Sourty, A., Bat‐Pitault, F., Regnery, K., Mayen, S., & Colson, S. (2024) · L Encéphale · doi:10.1016/j.encep.2024.04.007 · Cited by 3
Porter, C., Whitehead, R. E., & Hopkins, L. (2025) · Community Mental Health Journal · doi:10.1007/s10597-024-01433-w · Cited by 3
“…et al., 2006) and hyper-or hypo-sensitive sensory processing (Ben-Sasson et al., 2009; Sinclair et al., 2017), with some autistic people having a heightened pre-occupation on topics/interests (Van Steensel et al., 2011) and preferences for sameness/difficulties with change (Gotham et al., 2013).”
Brennan, J., Velasquez, M. J., & Davis, T. E. (2025) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-025-06750-x · Cited by 3
“…rates higher in autistic youth (i.e., 1.6 – 84%; Bougeard et al., 2021; Hollocks et al., 2023; Salazar et al., 2015; Simonoff et al., 2008; van Steensel et al., 2011; Vasa et al., 2020; White et al., 2009) than non-autistic youth (i.e., 2.4 – 17.5%; Costello et al., 2003; Polanczyk et…”
InfluentialIvarsson, M., Danielsson, H., & Imms, C. (2025) · BMC Psychology · doi:10.1186/s40359-025-02450-4 · Cited by 3
Malode, T. D., Chandurkar, P. A., Taksande, B. G., Tatode, A., Qutub, M., Premchandani, T., Umekar, M. J., & Taksande, J. (2025) · Medicine in Microecology · doi:10.1016/j.medmic.2025.100138 · Cited by 3
Autism Spectrum and Social Pragmatic Language Disorders
Livanis, A., Almodóvar, D., & Skolnik, E. (2017) · Springer eBooks · doi:10.1007/978-3-319-57196-6_19 · Cited by 4
The Influence of Demographic and Child Characteristics on Referral for Neuropsychological Evaluation
Pittenger, A., Erklin, S., & Wodka, E. L. (2018) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acy107 · Cited by 3
Parents’ Perceptions on Anxiety Symptoms in Children With Autism Spectrum Disorder
Syriopoulou–Delli, C. K., Polychronopoulou, S. A., Kolaitis, G. A., & Antoniou, A.-S. G. (2019) · Journal of Educational and Developmental Psychology · doi:10.5539/jedp.v9n2p104 · Cited by 3
‘Our normal is different’: autistic adults’ experiences of the family courts
George, R., Crane, L., & Remington, A. (2020) · Journal of Social Welfare and Family Law · doi:10.1080/09649069.2020.1751928 · Cited by 3
“While family court litigation is inherently stressful for all involved, it is known that there is a higher prevalence of anxiety disorders in the autistic population compared to non-autistic people (van Steensel et al. 2011).”
ResultUnderlying Mechanisms of Restricted and Repetitive Behaviors Across Typical and Atypical Development
Uljarević, M., Hedley, D., Linkovski, O., & Leekam, S. (2021) · Autism and child psychopathology series · doi:10.1007/978-3-030-66445-9_5 · Cited by 3
Nathanson, E. W., & Rispoli, K. M. (2021) · Journal of Applied School Psychology · doi:10.1080/15377903.2021.1941468 · Cited by 3
“…sensory sensitivities, increased risk for other mental health concerns, decreased quality of life, and higher levels of parental stress (van Steensel et al., 2011, 2012; White et al., 2009), it is vital to address this co-occurring disorder in schools to ensure better mental health and…”
BackgroundInfluentialBirdsey, N., & Walz, L. (2021) · The Cognitive Behaviour Therapist · doi:10.1017/s1754470x21000167 · Cited by 2
Metadata
- Authors
- van Steensel, F. J. A., Bögels, S. M., & Perrin, S.
- Affiliations
- University of Amsterdam (NL)
- King's College London (GB)
- Venue
- Clinical Child and Family Psychology Review
- Published
- 2011-07-07
- Volume
- 14
- Issue
- 3
- Pages
- 302-317
- ISSN
- 1096-4037 (ISSN-L)
- 1573-2827
- PMC
- PMC3162631
- OpenAlex
- W2138006810
- Cited by
- 1,463
- References
- 104
- Citations by year
- 2026: 147 · 2025: 105 · 2024: 94 · 2023: 109 · 2022: 134 · 2021: 137 · 2020: 138 · 2019: 112 · 2018: 107 · 2017: 94 · 2016: 83 · 2015: 70 · 2014: 59 · 2013: 52 · 2012: 21
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Clinical Child and Family Psychology Review (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion, other-oa)
- Research Portal (King's College London) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- autism spectrum disorder, anxiety disorders, comorbidities, children and adolescents, specific phobia, obsessive-compulsive disorder, social anxiety disorder, ASD subtypes, IQ
- MeSH terms
- Adolescent, Anxiety Disorders, Child, Child Development Disorders, Pervasive, Child, Preschool, Humans, Intelligence, Obsessive-Compulsive Disorder, Phobic Disorders, Comorbidity, Prevalence, Databases, Bibliographic
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