The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Metabolic and Structural Role of Thiamine in Nervous Tissues
Open accessAbstract
In the literature, previous descriptions of the role of thiamine (B1 vitamin) focused mostly on its biochemical functions as a coenzyme precursor of some key enzymes of the carbohydrate metabolism. This report reviews recent developments on the metabolic and structural role of thiamine, e.g., the coenzyme and noncoenzyme functions of the vitamin. Taking into account analysis of our experimental data relating to the effects of thiamine deficiency on developing central nervous system (CNS) and data available in literature, we seek to establish a clear difference between the metabolic and structural role of thiamine. Our experimental data indicate that the specific and nonspecific effects express two diametrically diverse functions of thiamine in development: the nonspecific effects show up the metabolic consequences of thiamine deficiency resulting in apoptosis and severe cellular deficit; inversely, the specific effects announced the structural consequences of thiamine deficiency, described as cellular membrane damage, irregular and ectopic cells. The review highlights the existence of noncoenzyme functions of this vitamin through its interactions with biological membranes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Citations
Cites
Free radicals and antioxidants in normal physiological functions and human disease
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269
RECOGNITION OF THE FETAL ALCOHOL SYNDROME IN EARLY INFANCY
Jones, K., & Smith, D. (1973) · The Lancet · doi:10.1016/s0140-6736(73)91092-1 · Cited by 2,780
Wickstrom, L., & Pettersson, K. (1964) · PubMed · Cited by 1,155
The role of thiamine deficiency in alcoholic brain disease.
Martin, P., Singleton, C. K., & Hiller-Sturmhöfel, S. (2003) · Europe PMC (PubMed Central) · Cited by 381
Mancuso, C. (2006) · Frontiers in bioscience · doi:10.2741/2130 · Cited by 290
Stirban, A. O., Negrean, M., Stratmann, B., Gawlowski, T., Horstmann, T., Götting, C., Kleesiek, K., Müller-Rösel, M., Koschinsky, T., Uribarri, J., et al. (2006) · Diabetes Care · doi:10.2337/dc06-0531 · Cited by 262
Myths and Misconceptions of Wernicke’s Encephalopathy: What Every Emergency Physician Should Know
Donnino, M. W., Vega, J., Miller, J. M., & Walsh, M. M. (2007) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2007.02.007 · Cited by 228
REVIEW: Vitamin transport and homeostasis in mammalian brain: focus on Vitamins B and E
Spector, R., & Johanson, C. E. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04773.x · Cited by 175
Lindhurst, M. J., Fiermonte, G., Song, S., Struys, E. A., Leonardis, F. D., Schwartzberg, P. L., Chen, A. Y.-C., Castegna, A., Verhoeven‐Duif, N. M., Mathews, C. K., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607661103 · Cited by 160
Interactions of oxidative stress with thiamine homeostasis promote neurodegeneration
Gibson, G. E. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(01)00120-6 · Cited by 155
Research works printed but not linked: 2
- Kerr JFR, Winterford CM, Harmon BV (1994) Morphological criteria for identifying apoptosis. Cell biology: a laboratoryhandbook. Academic Press Inc, pp 319–329
- Siegel G, Agranoff B, Albers RW, Molinoff P (1989) Basic neurochemistry, 4th edn. Raven Press, New York
Cited by
Sorted by citations
Items 101–121 of 121
Jeremic, D., Jiménez‐Díaz, L., & Navarro‐López, J. D. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.13.653795 · Cited by 1
THIAMINASE ACTIVITY OF MYOGLOBIN OXOFERRYL FORMS
Stepuro, I. I., Labor, S. A., Shuryberka, A. V., Stsiapura, V. I., Smirnov, V. Y., & Yantsevich, А. V. (2018) · Proceedings of the National Academy of Sciences of Belarus Biological Series · doi:10.29235/1029-8940-2018-63-2-176-187
Curious case of cardiac failure with pulmonary hypertension in a toddler
Kumar, S., Joji, P., Haneefa, S. M., Ahamed, Z., Kumar, K., & Vaidyanathan, B. (2020) · Journal of Paediatrics and Child Health · doi:10.1111/jpc.15211
Чугунов, А. В., Kazakov, K. A., & Kazakov, A. Y. (2020) · Russian Medical Inquiry · doi:10.32364/2587-6821-2020-4-9-606-611
Principles of Treatment of Patients with Diabetic Polyneuropathy in the COVID-19 Pandemic
Golovacheva, V. A., & Александровна, Г. А. (2021) · Meditsinskiy sovet = Medical Council · doi:10.21518/2079-701x-2021-19-126-133
Hechtman, L. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4377-2333-5.00179-6
Thiamine Deficiency and Poverty
Dias, F. M. V., Oliveira, A. S., da Silva, D. J., & Ribeiro, A. M. (2019) · Springer eBooks · doi:10.1007/978-3-319-55387-0_83
An investigation of the effects of thiamine in the experimental diabetic rat brain tissue
Akalın, Y., Bulut, S., Kuloğlu, T., Demir, C. F., & Taşçı, İ. (2020) · Gazzetta Medica Italiana Archivio per le Scienze Mediche · doi:10.23736/s0393-3660.19.04147-0
Laloğlu, E. (2024) · doi:10.69860/nobel.9786053359173.2
Saleem, R. A., Ramadan, M., SHEIK, M. S., BAHAMAN, J. S., ZARROL, S., Garaween, G. A., & Alhusseini, N. K. (2023) · Nutrición clínica y dietética hospitalaria/Nutrición clínica, dietética hospitalaria · doi:10.12873/434saleem
Thiamine Pyrophosphate Effects on Newborn Piglets as a Measure of Vitality and Survival Indicators
Islas-Fabila, P., Bonilla‐Jaime, H., Roldán-Santiago, P., de la Cruz-Cruz, L. A., Limón‐Morales, O., Jiménez-Collado, C. A., & Orozco-Gregorio, H. (2025) · Animals · doi:10.3390/ani15050619
A case report of monoplegia due to vitamin B1 deficiency
Shiraiwa, N., Iwanami, A., Ayuzawa, S., & Ohkoshi, N. (2025) · doi:10.5348/100023n06ns2025cr
Nutrition and Recovery in Esports
Arslan, S., & Aydın, A. (2025) · Springer eBooks · doi:10.1007/978-3-031-99625-2_5
Haidary, M., Ansari, M., Ansari, S., Rezayee, H., Hanifi, S., & Hossaini, D. (2025) · Alcoholism Treatment Quarterly · doi:10.1080/07347324.2025.2603655
Canto, E. A., Asghar, M. R., Bawaneh, S., & Chen, Y.-T. (2025) · BMJ Case Reports · doi:10.1136/bcr-2025-265745
Peripheral polyneuropathy in prediabetes and metabolic syndrome (review and clinical case)
Пизова, Н. В., & Pizov, A. V. (2026) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2026-107
Jeremic, D., Jiménez‐Díaz, L., & Navarro‐López, J. D. (2026) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2026.109417 · Cited by 1
Dietary and nutritional interventions for reducing neurotoxic effects
Velugolu, V. S. K., & Kumar, P. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44287-2.00037-5
The maternal gut–fetal brain axis: role of maternal microbial metabolome in early neurodevelopment
Scoglio, M. J., Samala, T., Ghalat, N. J., Jayaraman, A., & Pettersson, S. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1903574
Mummadi, M. K., Kumar, K. A., Pagidoju, S., Motapalukula, S., Ramanujam, K., Reddy, V., Kalashikam, R. R., Reddy, N. S., & Nalli, C. (2026) · Human Nutrition & Metabolism · doi:10.1016/j.hnm.2026.200391
A study of selective vulnerability to diabetes of nerves supplying the ileum using in vitro models
Voukali, E. (2013) · UCL Discovery (University College London)
Metadata
- Authors
- Bâ, A.
- Affiliations
- Université Félix Houphouët-Boigny (CI)
- Corresponding author
- Bâ, Abdoulaye
- ORCID
- Bâ, Abdoulaye
- Venue
- Cellular and Molecular Neurobiology
- Published
- 2008-07-19
- Volume
- 28
- Issue
- 7
- Pages
- 923-931
- ISSN
- 0272-4340 (ISSN-L)
- 1573-6830
- PMC
- PMC11514992
- OpenAlex
- W2105339966
- Cited by
- 121
- References
- 66
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 7 · 2023: 13 · 2022: 7 · 2021: 7 · 2020: 12 · 2019: 8 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 6
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Neurobiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
- Keywords
- thiamine, thiamine deficiency, central nervous system development, apoptosis, membrane damage
- MeSH terms
- Animals, Brain, Cell Membrane, Hippocampus, Humans, Nerve Degeneration, Neurons, Thiamine, Thiamine Deficiency, Apoptosis, Rats, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
