The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Metabolic and Structural Role of Thiamine in Nervous Tissues
Open accessAbstract
In the literature, previous descriptions of the role of thiamine (B1 vitamin) focused mostly on its biochemical functions as a coenzyme precursor of some key enzymes of the carbohydrate metabolism. This report reviews recent developments on the metabolic and structural role of thiamine, e.g., the coenzyme and noncoenzyme functions of the vitamin. Taking into account analysis of our experimental data relating to the effects of thiamine deficiency on developing central nervous system (CNS) and data available in literature, we seek to establish a clear difference between the metabolic and structural role of thiamine. Our experimental data indicate that the specific and nonspecific effects express two diametrically diverse functions of thiamine in development: the nonspecific effects show up the metabolic consequences of thiamine deficiency resulting in apoptosis and severe cellular deficit; inversely, the specific effects announced the structural consequences of thiamine deficiency, described as cellular membrane damage, irregular and ectopic cells. The review highlights the existence of noncoenzyme functions of this vitamin through its interactions with biological membranes.
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Metadata
- Authors
- Bâ, A.
- Affiliations
- Université Félix Houphouët-Boigny (CI)
- Corresponding author
- Bâ, Abdoulaye
- ORCID
- Bâ, Abdoulaye
- Venue
- Cellular and Molecular Neurobiology
- Published
- 2008-07-19
- Volume
- 28
- Issue
- 7
- Pages
- 923-931
- ISSN
- 0272-4340 (ISSN-L)
- 1573-6830
- PMC
- PMC11514992
- OpenAlex
- W2105339966
- Cited by
- 121
- References
- 66
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 7 · 2023: 13 · 2022: 7 · 2021: 7 · 2020: 12 · 2019: 8 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 6
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Neurobiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
- Keywords
- thiamine, thiamine deficiency, central nervous system development, apoptosis, membrane damage
- MeSH terms
- Animals, Brain, Cell Membrane, Hippocampus, Humans, Nerve Degeneration, Neurons, Thiamine, Thiamine Deficiency, Apoptosis, Rats, Neurogenesis
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