Effects of theanine on growth of human lung cancer and leukemia cells as well as migration and invasion of human lung cancer cells
Open accessAbstract
The aim of this study is to investigate the effects of theanine, a tea characteristic amino acid, on human lung cancer and leukemia cells. In the present study, we have demonstrated that theanine suppressed the in vitro and ex vivo growth of human non-small cell lung cancer A549 and leukemia K562 cell lines in dose- and time-dependant manners. In addition, theanine displayed the inhibitory effect on the migration of A549 cells. More importantly, theanine enhanced the anticancer activity of anticancer agents such as trichostatin A (the histone deacetylase inhibitor), berbamine and norcantharidin (the anticancer drugs in China) by strongly reducing the viability and/or migration rate in A549 cells. In addition, theanine significantly suppressed A549 cell invasion. Suppression of A549 cell migration may be one of the important mechanisms of action of theanine against the A549 cell invasion. Our present results suggest that theanine may have the wide therapeutic and/or adjuvant therapeutic application in the treatment of human lung cancer and leukemia.
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48-h L-THE treatment induced in vitro and ex vivo growth of human non-small cell lung cancer A549 and leukemia K562 cell lines in dose- and time-dependent manners.
“48-h L-THE treatment induced in vitro and ex vivo growth of human non-small cell lung cancer A549 and leukemia K562 cell lines in dose-and time-dependant manners [80]”
From l-Theanine as a Functional Food Additive: Its Role in Disease Prevention and Health Promotion (2016) · cites this paper as [80]
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- Authors
- Liu, Q., Duan, H., Luan, J., Yagasaki, K., & Zhang, G.
- Affiliations
- Yantai University (CN)
- Corresponding author
- Zhang, Guoying
- Venue
- Cytotechnology
- Published
- 2009-04
- Volume
- 59
- Issue
- 3
- Pages
- 211-217
- ISSN
- 0920-9069 (ISSN-L)
- 1573-0778
- PMC
- PMC2774573
- OpenAlex
- W2072886435
- Cited by
- 83
- References
- 10
- Citations by year
- 2025: 1 · 2024: 9 · 2023: 7 · 2022: 4 · 2021: 6 · 2020: 9 · 2019: 7 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 6 · 2013: 3 · 2012: 5
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cytotechnology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Yantai University
- Department of Science and Technology of Shandong Province
- Ministry of Education of the People's Republic of China
- Ministry of Human Resources and Social Security
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- theanine, lung cancer, leukemia, non-small cell lung cancer, A549 cells, K562 cells, cell migration, cell invasion, histone deacetylase inhibitors, trichostatin A, berbamine, norcantharidin, anticancer agents, tumor cell growth inhibition
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