A pilot phase II trial of all-trans retinoic acid (Vesanoid) and paclitaxel (Taxol) in patients with recurrent or metastatic breast cancer
Abstract
Purpose We investigated a combination therapy with weekly paclitaxel and all trans-retinoic acid (ATRA) for tolerability, response to treatment, time to progression and survival in previously treated patients with metastatic or recurrent breast cancer. Our rationale was based on preclinical studies demonstrating potentiation of the cytotoxic effects of taxanes and induction of differentiation by ATRA.Patients and methods Seventeen patients with previously treated metastatic or recurrent breast cancer were enrolled to a regimen of all-trans retinoic acid (Vesanoid, tretinoin, Hoffman-La Roche, Inc.) 45 mg/m(2) PO daily for 4 days starting 2 days before a 1 h treatment with paclitaxel (Taxol, Bristol-Myers Squibb, Plainsboro, NJ) 80 mg/m(2) IV administered weekly for 3 weeks, repeated in 28 day cycles until disease progression or until no longer tolerated. Patients were evaluated for toxicity, response, time to progression and survival. Patients were primarily African American and Latino, representative of the population served by our Cancer Center.Results The regimen was relatively well tolerated. There were nine grade 3 and one grade 4 toxic events. We administered 162 treatment cycles with a mean of 7.5 per patient (range 1-22, median 5). Three patients had a partial response (17.6%) and ten patients had stable disease (58.8%), with an overall clinical benefit of 76.4%. Median time to progression was 6.0 months (range 1-21, mean 7.7 months). Fourteen evaluable patients had a median survival of 16 months (range 1-68 months, mean 25.2 months).Conclusions The data suggest this is a well tolerated regimen with modest response rates but with time to progression and survival rates similar to those reported for paclitaxel alone and relatively high rates of stable disease in this sample of patients.
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When RA was combined with tamoxifen or paclitaxel it showed moderate antitumoral activity.
“when RA was combined with tamoxifen or paclitaxel it showed moderate antitumoral activity110,111.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [111]
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- Authors
- Bryan, M., Pulte, E. D., Toomey, K. C., Pliner, L., Pavlick, A. C., Saunders, T., & Wieder, R.
- Affiliations
- Rutgers New Jersey Medical School (US)
- Somerset Medical Center (US)
- New York University (US)
- Corresponding author
- Wieder, Robert
- Venue
- Investigational New Drugs
- Published
- 2010-07-02
- Volume
- 29
- Issue
- 6
- Pages
- 1482-1487
- ISSN
- 0167-6997 (ISSN-L)
- 1573-0646
- OpenAlex
- W2076400885
- Cited by
- 77
- References
- 21
- Citations by year
- 2025: 3 · 2024: 7 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 7 · 2018: 5 · 2017: 7 · 2016: 4 · 2015: 5 · 2014: 9 · 2013: 7 · 2012: 3
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Investigational New Drugs (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Advanced Breast Cancer Therapies
- Keywords
- all-trans retinoic acid, paclitaxel, combination chemotherapy, breast cancer recurrence, metastatic breast cancer, previously treated patients, treatment toxicity, time to progression, survival, stable disease, differentiation therapy
- MeSH terms
- Aged, Antineoplastic Combined Chemotherapy Protocols, Black or African American, Breast Neoplasms, Female, Hispanic or Latino, Humans, Middle Aged, Neoplasm Metastasis, Neoplasm Recurrence, Local, Pilot Projects, Tretinoin, Survival Rate, Treatment Outcome, Paclitaxel, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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