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Cited by 81Oral microbiology and periodontitis researchDementia and Cognitive Impairment ResearchDental Health and Care Utilization

Influence of periodontal disease on risk of dementia: A systematic literature review and a meta-analysis

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Nadim, Rizwan, Tang, Jie, Dilmohamed, Amena, Yuan, Siyang, Wu, Changhao, Bakre, Aishat T., Partridge, Martin, Ni, Jindong +3 more·2020·European Journal of Epidemiology
DOI 10.1007/s10654-020-00648-x
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Abstract

Periodontal disease (PD) is common and increases cardiovascular diseases. However, it is unclear whether PD is associated with increased risk of dementia. We carried out a systematic review and meta-analysis to investigate the influence of PD on dementia. We projected the number of dementia cases to be saved by reducing PD prevalence in the world. We searched cohort and case-control studies reporting the association of PD with all dementia (or any specific type of dementia) through PubMed, MEDLINE, PsycINFO, SocINDEX, CINHAL, and CNKI until 7th November 2018. Five cohorts and seven case-control studies were identified for review. We pooled eligible data to calculate relative risk (RR) of dementia in relation to PD and computed the number of dementia cases saved through reducing PD prevalence. Of 12 studies, six were undertaken in Asia, four in Europe and two in America. Eleven studies showed a positive association between PD and the risk of dementia, of which 10 were significant, and one reported a non-significant inverse association. Overall their quality was good. Pooled RR of dementia in relation to PD from all high quality studies was 1.38 (95%CI 1.01-1.90); in the five cohorts was 1.18 (1.06-1.31) and in the two case-control studies 2.25 (1.48-3.42). A 50% reduction in the current prevalence of 20% of PD in the population could save 850,000 (630,000-1,420,000) patients with dementia in the world. PD could increase the risk of incident dementia. Preventing and treating PD could contribute to controlling the global epidemic of dementia.

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  • There is a strong epidemiologic association between periodontitis and Alzheimer's disease and related dementia.

    “There is a strong epidemiologic association between periodontitis (PD) and ADRD [5,6,7,8,9,10,11,12,13] but how these two diseases intersect and whether it is at the level of causation is unclear.”

    From Oral Microbially-Induced Small Extracellular Vesicles Cross the Blood–Brain Barrier (2024) · cites this paper as [13]

    The Meta-analysis section reports a significant association between periodontal disease and dementia (pooled RR 1.38, 95% CI 1.01–1.90). However, the section “How strong are the associations between PD and dementia?” explicitly calls the overall association moderate, so “strong” overstates the source. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Nadim, R., Tang, J., Dilmohamed, A., Yuan, S., Wu, C., Bakre, A. T., Partridge, M., Ni, J., Copeland, J. R., Anstey, K. J., & Chen, R.
Affiliations
  • University of Wolverhampton (GB)
  • University of Surrey (GB)
  • Guangdong Medical College (CN)
  • University of Liverpool (GB)
  • UNSW Sydney (AU)
Corresponding author
Chen, Ruoling
ORCID
Venue
European Journal of Epidemiology
Publisher
Springer Science and Business Media LLC
Published
2020-06-12
Volume
35
Issue
9
Pages
821-833
ISSN
  • 0393-2990 (ISSN-L)
  • 1573-7284
DOI
10.1007/s10654-020-00648-x
OpenAlex
W3034487604
Cited by
81
References
3
Citations by year
2026: 10 · 2025: 9 · 2024: 9 · 2023: 13 · 2022: 19 · 2021: 16 · 2020: 5
FWCI
2.15
Type
journal article
Language
en
Open access
Licence
Locations
  • European Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
  • Discovery Research Portal (University of Dundee) (publishedVersion, other-oa)
  • Wolverhampton Intellectual Repository and E-Theses (University of Wolverhampton) (acceptedVersion, cc-by-nc-nd)
  • UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
  • Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
Funders
  • University of Wolverhampton
  • Anhui Medical University
  • Biotechnology and Biological Sciences Research Council (BB/P004695/1, 1R01AG049321-01A1, BB/G015554/1)
  • National Health and Medical Research Council (1102694)
  • National Institute on Aging (BB/P004695/1, R01AG049321)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
Keywords
periodontal disease, dementia, dementia risk, periodontitis, dementia prevention, oral health, cardiovascular disease
MeSH terms
Alzheimer Disease, Dementia, Humans, Oral Health, Periodontal Diseases, Periodontitis, Prevalence

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