Immune cell diversity contributes to the pathogenesis of myocarditis
Abstract
Myocarditis (MCD) is a type of inflammatory disease in which inflammatory cells infiltrate the myocardium, leading to cardiac dysfunction, myocardial necrosis, and fibrosis. Although it has been reported that MCD is mediated by T cells, the immune system is complex and includes many types of immune cells that interact with one another. Through investigations of the inflammatory responses in MCD including myocardial necrosis, fibrosis, and arrhythmia, we have gained further insight into the pathogenesis of MCD. This article aims to discuss the diversity and the roles of immune cells involved in the pathogenesis of MCD. Moreover, immunotherapy for the treatment of MCD remains controversial, and further investigation is required to identify accurate immunotherapies for special cell types.
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Myocarditis is a type of T cell-mediated inflammation.
“As reported, myocarditis is a type of T cell-mediated inflammation. 26”
From Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis. (2020) · cites this paper as [26]
NK cells were the only resource of IFNγ involved in the pathogenesis of EAM.
“NK cells were the only resource of IFNγ involved in the pathogenesis of EAM (Figure IXB in the Data Supplement). 26”
From Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis. (2020) · cites this paper as [26]
Neutrophils represent a small proportion of the cardiac immune cell systems in the heart at the resting state.
“Neutrophils represent a small proportion of the cardiac immune cell systems in the heart at the resting state 26”
From Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis. (2020) · cites this paper as [26]
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Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis.
Hua, X., Hu, G., Hu, Q., Chang, Y., Hu, Y., Gao, L., Chen, X., Yang, P.-C., Zhang, Y., Li, M., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.043545 · Cited by 201 · see citing works
Self-citationThe Roles of Cardiac Fibroblasts and Endothelial Cells in Myocarditis
Xuan, Y., Chen, C., Wen, Z., & Wang, D. W. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.882027 · Cited by 35 · see citing works
- Authors
- Hua, X., & Song, J.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Song, Jiangping
- Venue
- Heart Failure Reviews
- Published
- 2019-05-02
- Volume
- 24
- Issue
- 6
- Pages
- 1019-1030
- ISSN
- 1382-4147 (ISSN-L)
- 1573-7322
- OpenAlex
- W2943345723
- Cited by
- 37
- References
- 9
- Citations by year
- 2025: 6 · 2024: 7 · 2023: 13 · 2022: 7 · 2021: 2 · 2020: 1 · 2018: 1
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Heart Failure Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
- Keywords
- myocarditis, T cells, myocardial necrosis, myocardial fibrosis, cardiac arrhythmias, immunotherapy, pathogenesis
- MeSH terms
- Animals, Histocompatibility Antigens Class II, B-Lymphocytes, Female, Fibrosis, Humans, Immune System, Immunotherapy, Killer Cells, Natural, Macrophages, Male, Myocarditis, Myocardium, Ventricular Remodeling, Models, Animal, T-Lymphocytes, Regulatory, Mice, Receptors, CCR2, Adaptive Immunity
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