The Roles of Cardiac Fibroblasts and Endothelial Cells in Myocarditis
Open accessAbstract
In myocarditis caused by various etiologies, activated immune cells and the immune regulatory factors released by them play important roles. But in this complex microenvironment, non-immune cells and non-cardiomyocytes in the heart, such as cardiomyocytes (CMs), cardiac fibroblasts (CFs) and endothelial cells (ECs), play the role of “sentinel”, amplify inflammation, and interact with the cardiomyocytes. The complex interactions between them are rarely paid attention to. This review will re-examine the functions of CFs and ECs in the pathological conditions of myocarditis and their direct and indirect interactions with CMs, in order to have a more comprehensive understanding of the pathogenesis of myocarditis and better guide the drug development and clinical treatment of myocarditis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
hCF contributes to structural integrity and contractility by producing ECM proteins, such as collagen and fibronectin, which support cellular organization and mechanical stability.
“hCF contributes to structural integrity and contractility by producing ECM proteins, such as collagen and fibronectin, which support cellular organization and mechanical stability.[ 52 , 53 , 54 ]”
From Engineered in vitro multi-cell type ventricle model generates long-term pulsatile flow and modulates cardiac output in response to cardioactive drugs (2025) · cites this paper as [52]
The CFs section (page unavailable) says cardiac fibroblasts synthesize a collagen-rich ECM network that provides structural integrity and biomechanical signals. The ECM section (page unavailable) also describes that network as supporting cardiac cells. The passages do not specifically establish this for human cardiac fibroblasts (hCF), name fibronectin, or say that ECM production contributes to contractility. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Down-Regulation of Na+/K+ATPase Activity by Human Parvovirus B19 Capsid Protein VP1
Almilaji, A., Szteyn, K., Fein, E., Pakladok, T., Muñoz, C., Elvira, B., Towhid, S. T., Alesutan, I., Shumilina, E. V., Bock, C. –., et al. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350083 · Cited by 8,675 · see citing works
Shedding light on the cell biology of extracellular vesicles
van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369 · see citing works
Vos, T., Barber, R. M., Bell, B., Bertozzi-Villa, A., Biryukov, S., Bolliger, I., Charlson, F., Davis, A., Degenhardt, L., Dicker, D., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60692-4 · Cited by 6,414 · see citing works
Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles
Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186 · see citing works
The Extracellular Matrix: Not Just Pretty Fibrils
Hynes, R. O. (2009) · Science · doi:10.1126/science.1176009 · Cited by 3,527 · see citing works
Caforio, A. L. P., Pankuweit, S., Arbustini, E., Basso, C., Gimeno-Blanes, J., Felix, S. B., Fu, M., Heliö, T., Heymans, S., Jahns, R., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht210 · Cited by 3,479 · see citing works
Transforming Growth Factor-β Signaling in Immunity and Cancer
Batlle, E., & Massagué, J. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.024 · Cited by 2,366 · see citing works
Caterina, R. D., Libby, P., Peng, H., Thannickal, V. J., Rajavashisth, T. B., Gimbrone, M. A., Shin, W. S., & Liao, J. K. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118074 · Cited by 1,781 · see citing works
Traffic Signals on Endothelium for Lymphocyte Recirculation and Leukocyte Emigration
Springer, T. A. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.004143 · Cited by 1,497 · see citing works
Revisiting Cardiac Cellular Composition
Pinto, A. R., Ilinykh, A., Ivey, M. J., Kuwabara, J. T., D’Antoni, M. L., Debuque, R., Chandran, A., Wang, L., Arora, K., Rosenthal, N. A., et al. (2016) · Circulation Research · doi:10.1161/circresaha.115.307778 · Cited by 1,400 · see citing works
Ratajczak, J., Wysoczynski, M., Hayek, F., Janowska-Wieczorek, A., & Ratajczak, M. Z. (2006) · Leukemia · doi:10.1038/sj.leu.2404296 · Cited by 1,340 · see citing works
TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology
Morikawa, M., Derynck, R., & Miyazono, K. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021873 · Cited by 1,321 · see citing works
Myocarditis. A histopathologic definition and classification.
Aretz, H. T., Billingham, M. E., Edwards, W. D., Factor, S. M., Fallon, J. T., Fenoglio, J. J., Olsen, E. G. J., & Schöen, F. J. (1987) · PubMed · Cited by 1,307 · see citing works
Vascular Endothelial Cell Biology: An Update
Krüger‐Genge, A., Blocki, A. M., Franke, R., & Jung, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184411 · Cited by 1,167 · see citing works
The Assessment of Endothelial Function
Flammer, A. J., Anderson, T. J., Celermajer, D. S., Creager, M. A., Deanfield, J. E., Ganz, P., Hamburg, N. M., Lüscher, T. F., Shechter, M., Taddei, S., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.093245 · Cited by 1,157 · see citing works
Bang, C., Bátkai, S., Dangwal, S., Gupta, S. K., Foinquinos, A., Holzmann, A., Just, A., Remke, J., Zimmer, K., Zeug, A., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci70577 · Cited by 979 · see citing works
A pathogenic picornavirus acquires an envelope by hijacking cellular membranes
Feng, Z., Hensley, L., McKnight, K. L., Hu, F., Madden, V. J., Ping, L., Jeong, S., Walker, C. M., Lanford, R. E., & Lemon, S. M. (2013) · Nature · doi:10.1038/nature12029 · Cited by 712 · see citing works
PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells
Bonfanti, R., Furie, B., Furie, B., & Wagner, D. D. (1989) · Blood · doi:10.1182/blood.v73.5.1109.1109 · Cited by 546 · see citing works
Siwik, D. A., Chang, D. L. F., & Colucci, W. S. (2000) · Circulation Research · doi:10.1161/01.res.86.12.1259 · Cited by 517 · see citing works
TGF-β Signaling in Control of Cardiovascular Function
Goumans, M.-J., & ten Dijke, P. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022210 · Cited by 360 · see citing works
Sturtzel, C. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-57613-8_4 · Cited by 268 · see citing works
Devaux, B., Scholz, D., Hirche, A., Klövekorn, W. P., & Schaper, J. (1997) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a015268 · Cited by 264 · see citing works
ENDOTHELIAL-CARDIOMYOCYTE INTERACTIONS IN CARDIAC DEVELOPMENT AND REPAIR
Hsieh, P. C. H., Davis, M. E., Lisowski, L. K., & Lee, R. T. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040104.124629 · Cited by 242 · see citing works
Kühl, U., Noutsias, M., Seeberg, B., & Schultheiß, H. (1996) · Heart · doi:10.1136/hrt.75.3.295 · Cited by 240 · see citing works
Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation
Kohl, P. K., Camelliti, P., Burton, F. L., & Smith, G. L. (2005) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2005.06.096 · Cited by 231 · see citing works
Cardiovascular Manifestations of COVID-19 Infection
Magadum, A., & Kishore, R. (2020) · Cells · doi:10.3390/cells9112508 · Cited by 224 · see citing works
Cell Adhesion Molecules—Update
Elangbam, C. S., Qualls, C. W., & Dahlgren, R. R. (1997) · Veterinary Pathology · doi:10.1177/030098589703400113 · Cited by 215 · see citing works
Cardiac myocyte exosomes: stability, HSP60, and proteomics
Malik, Z. A., Kott, K. S., Poe, A. J., Kuo, T., Chen, L., Ferrara, K. W., & Knowlton, A. A. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00835.2012 · Cited by 209 · see citing works
Bültmann, B. D., Klingel, K., Sotlar, K., Bock, C. –., Baba, H. A., Sauter, M., & Kandolf, R. (2003) · Human Pathology · doi:10.1053/hupa.2003.48 · Cited by 205 · see citing works
Mechanisms of Cardiac Fibrosis in Inflammatory Heart Disease
Kania, G., Błyszczuk, P., & Eriksson, U. (2009) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2010.02.005 · Cited by 188 · see citing works
Kumar, S., Wang, G., Zheng, N., Cheng, W., Ouyang, K., Lin, H., Liao, Y., & Liu, J. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.12267 · Cited by 181 · see citing works
Yuan, J., Liu, H., Gao, W., Zhang, L., Ye, Y., Yuan, L., Ding, Z., Wu, J., Kang, L., Zhang, X., et al. (2018) · Theranostics · doi:10.7150/thno.22878 · Cited by 174 · see citing works
Persistent Expression of Cytokine in the Chronic Stage of Viral Myocarditis in Mice
Shioi, T., Matsumori, A., & Sasayama, S. (1996) · Circulation · doi:10.1161/01.cir.94.11.2930 · Cited by 173 · see citing works
Neutralization of IL‐17 by active vaccination inhibits IL‐23‐dependent autoimmune myocarditis
Sonderegger, I., Röhn, T. A., Kurrer, M. O., Iezzi, G., Zou, Y., Kastelein, R. A., Bachmann, M. F., & Köpf, M. (2006) · European Journal of Immunology · doi:10.1002/eji.200636484 · Cited by 165 · see citing works
Extracellular matrix-mediated cellular communication in the heart
Valiente-Alandí, Í., Schafer, A. E., & Blaxall, B. C. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.01.011 · Cited by 164 · see citing works
Functional crosstalk between cardiac fibroblasts and adult cardiomyocytes by soluble mediators
Cartledge, J. E., Kane, C., Dias, P., Tesfom, M., Clarke, L., Mckee, B., Ayoubi, S. A., Chester, A. H., Yacoub, M. H., Camelliti, P., et al. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvu264 · Cited by 156 · see citing works
Verdonschot, J. A. J., Hazebroek, M. R., Merken, J. J., Debing, Y., Dennert, R. M., Rocca, H. B., & Heymans, S. R. B. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.665 · Cited by 148 · see citing works
Coxsackie B3 virus can replicate in cultured human foetal heart cells and is inhibited by interferon
Kandolf, R., Canu, A., & Hofschneider, P. H. (1985) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(85)80019-5 · Cited by 136 · see citing works
Wang, Y., Yao, F., Wang, L., Li, Z., Ren, Z., Li, D., Zhang, M., Han, L., Wang, S.-Q., Zhou, B., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16204-w · Cited by 122 · see citing works
Luo, H., Li, X., Li, T., Zhao, L., He, J., Zha, L., Qi, Q., & Yu, Z. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy231 · Cited by 117 · see citing works
Fredj, S., Bescond, J., Louault, C., & Potreau, D. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20197 · Cited by 114 · see citing works
Ruwhof, C., van Wamel, A. J. E. T., Egas, J. M., & van der Laarse, A. (2000) · Molecular and Cellular Biochemistry · doi:10.1023/a:1007046105745 · Cited by 114 · see citing works
Endothelial cells release cardioprotective exosomes that may contribute to ischaemic preconditioning
Davidson, S. M., Riquelme, J. A., Zheng, Y. H., Vicencio, J. M., Lavandero, S., & Yellon, D. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-34357-z · Cited by 111 · see citing works
Coxsackievirus B Escapes the Infected Cell in Ejected Mitophagosomes
Sin, J., McIntyre, L., Stotland, A., Feuer, R., & Gottlieb, R. A. (2017) · Journal of Virology · doi:10.1128/jvi.01347-17 · Cited by 103 · see citing works
Endothelin and endothelin receptors in the renal and cardiovascular systems
Vignon‐Zellweger, N., Heiden, S., Miyauchi, T., & Emoto, N. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.03.026 · Cited by 102 · see citing works
Fibroblast-mediated pathways in cardiac hypertrophy
Fujiu, K., & Nagai, R. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.01.013 · Cited by 93 · see citing works
Kania, G., Błyszczuk, P., Stein, S., Valaperti, A., Germano, D., Dirnhofer, S., Hunziker, L., Matter, C. M., & Eriksson, U. (2009) · Circulation Research · doi:10.1161/circresaha.109.196287 · Cited by 91 · see citing works
Wang, X., Morelli, M. B., Matarese, A., Sardu, C., & Santulli, G. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12584 · Cited by 88 · see citing works
Cardiosomal microRNAs Are Essential in Post-Infarction Myofibroblast Phenoconversion
Morelli, M. B., Shu, J., Sardu, C., Matarese, A., & Santulli, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010201 · Cited by 84 · see citing works
The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis
Hou, X., Chen, G., Bracamonte-Baran, W., Choi, H. S., Diny, N. L., Sung, J., Hughes, D., Won, T., Wood, M. K., Talor, M. V., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.007 · Cited by 83 · see citing works
Mayourian, J., Ceholski, D. K., Gonzalez, D. M., Cashman, T. J., Sahoo, S., Hajjar, R. J., & Costa, K. D. (2018) · Circulation Research · doi:10.1161/circresaha.117.311589 · Cited by 81 · see citing works
Cardiac fibroblasts protect cardiomyocytes against lethal ischemia–reperfusion injury
Abrial, M., Silva, C. C. D., Pillot, B., Augeul, L., Ivanes, F., Teixeira, G., Cartier, R., Angoulvant, D., Ovize, M., & Ferrera, R. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.01.005 · Cited by 79 · see citing works
Schmidt‐Lucke, C., Spillmann, F., Bock, C. –., Kühl, U., Linthout, S. V., Schultheiß, H., & Tschöpe, C. (2010) · The Journal of Infectious Diseases · doi:10.1086/650700 · Cited by 73 · see citing works
Shen, J., Zhai, J., You, Q., Zhang, G., He, M., Yao, X., & Shen, L. (2020) · Oncogene · doi:10.1038/s41388-020-1197-4 · Cited by 73 · see citing works
Diny, N. L., Hou, X., Barin, J. G., Chen, G., Talor, M. V., Schaub, J., Russell, S. D., Klingel, K., Rose, N. R., & Čiháková, D. (2016) · European Journal of Immunology · doi:10.1002/eji.201646557 · Cited by 70 · see citing works
Endothelial Expression of MHC Class II Molecules in Autoimmune Disease
Turesson, C. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043453414 · Cited by 70 · see citing works
Cosme, J., Guo, H., Hadipour‐Lakmehsari, S., Emili, A., & Gramolini, A. O. (2017) · Journal of Proteome Research · doi:10.1021/acs.jproteome.7b00144 · Cited by 68 · see citing works
Wang, L., & Zhang, J. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s240660 · Cited by 68 · see citing works
Bachelier, K., Biehl, S., Schwarz, V., Kindermann, I., Kandolf, R., Sauter, M., Ukena, C., Yılmaz, A., Sliwa, K. S., Bock, C. –., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176311 · Cited by 64 · see citing works
Fatal Eosinophilic Myocarditis Develops in the Absence of IFN-γ and IL-17A
Barin, J. G., Baldeviano, G. C., Talor, M. V., Wu, L., Ong, S., Fairweather, D., Bedja, D., Stickel, N., Fontes, J. A., Cardamone, A., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301282 · Cited by 63 · see citing works
Dougherty, J. A., Kumar, N., Noor, M., Angelos, M. G., Khan, M., Chen, C., & Khan, M. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01794 · Cited by 60 · see citing works
Self-citationZhang, Q., Shang, M., Zhang, M., Wang, Y., Chen, Y., Wu, Y.-N., Liu, M., Song, J.-Q., & Liu, Y. (2016) · BMC Cell Biology · doi:10.1186/s12860-016-0100-1 · Cited by 60 · see citing works
Immunomodulation and matrix metalloproteinases in viral myocarditis
Westermann, D., Savvatis, K., Schultheiß, H., & Tschöpe, C. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.08.019 · Cited by 55 · see citing works
Regulation of endothelial cell function by pro- and anti-inflammatory cytokines
Mantovani, A., Garlanda, C., Introna, M., & Vecchi, A. (1998) · Transplantation Proceedings · doi:10.1016/s0041-1345(98)01402-x · Cited by 54 · see citing works
Vallbracht, K. B., Schwimmbeck, P. L., Kühl, U., Rauch, U., Seeberg, B., & Schultheiß, H. (2005) · Circulation · doi:10.1161/01.cir.0000160863.30496.9b · Cited by 53 · see citing works
Werner, L., DEUTSCH, V., Barshack, I., Miller, H. I., Keren, G., & George, J. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.06.015 · Cited by 53 · see citing works
Extracellular Vesicles in Herpes Viral Spread and Immune Evasion
Bello‐Morales, R., & López‐Guerrero, J. A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02572 · Cited by 53 · see citing works
Sca‐1 <sup>+</sup> cardiac fibroblasts promote development of heart failure
Chen, G., Bracamonte‐Baran, W., Diny, N. L., Hou, X., Talor, M. V., Fu, K., Liu, Y., Davogustto, G., Vasquez, H., Taegtmeyer, H., et al. (2018) · European Journal of Immunology · doi:10.1002/eji.201847583 · Cited by 53 · see citing works
The dynamics of fibroblast–myocyte–capillary interactions in the heart
Bowers, S., Borg, T. K., & Baudino, T. A. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05094.x · Cited by 50 · see citing works
Boza, P., Ayala, P., Vivar, R., Humeres, C. D., Cáceres, F. T., Muñoz, C., Garcı́a, L., Hermoso, M. A., & Dı́az-Araya, G. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.05.001 · Cited by 49 · see citing works
Telbivudine in Chronic Lymphocytic Myocarditis and Human Parvovirus B19 Transcriptional Activity
Linthout, S. V., Elsanhoury, A., Klein, O., Sosnowski, M., Miteva, K., Laßner, D., Abou‐El‐Enein, M., Pieske, B. M., Kühl, U., & Tschöpe, C. (2018) · ESC Heart Failure · doi:10.1002/ehf2.12341 · Cited by 48 · see citing works
Cardiac Fibroblasts Aggravate Viral Myocarditis: Cell Specific Coxsackievirus B3 Replication
Lindner, D., Li, J., Savvatis, K., Klingel, K., Blankenberg, S., Tschöpe, C., & Westermann, D. (2014) · Mediators of Inflammation · doi:10.1155/2014/519528 · Cited by 47 · see citing works
Chen, C., Hsu, S.-Y., Chiu, C., & Leu, S. (2019) · Cells · doi:10.3390/cells8080935 · Cited by 47 · see citing works
Self-citationPummerer, C., Grässl, G., Sailer, M., Bachmaier, K., Penninger, J. M., & Neu, N. (1996) · PubMed · Cited by 45 · see citing works
Infectious myocarditis: the role of the cardiac vasculature
Woudstra, L., Juffermans, L. J. M., van Rossum, A. C., Niessen, H. W. M., & Krijnen, P. A. J. (2018) · Heart Failure Reviews · doi:10.1007/s10741-018-9688-x · Cited by 42 · see citing works
Sniegon, I., Prieß, M., Heger, J., Schulz, R., & Euler, G. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112290 · Cited by 41 · see citing works
Vallbracht, K. B., Schwimmbeck, P. L., Seeberg, B., Kühl, U., & Schultheiß, H. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01990-3 · Cited by 40 · see citing works
Marino, A. P. M. P., Silva, A. A., Pinho, R. T., & Lannes-Vieira, J. (2003) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2003000800020 · Cited by 39 · see citing works
Vegter, S., Tolley, K. H., Waterworth, T. W., Jones, H., Jones, S. T., & Jewell, D. P. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12369 · Cited by 37 · see citing works
Immune cell diversity contributes to the pathogenesis of myocarditis
Hua, X., & Song, J. (2019) · Heart Failure Reviews · doi:10.1007/s10741-019-09799-w · Cited by 37 · see citing works
Heim, A., Grumbach, I. M., Pring‐Åkerblom, P., Stille‐Siegener, M., Müller, G., Kandolf, R., & Figulla, H. (1997) · Antiviral Research · doi:10.1016/s0166-3542(97)01028-0 · Cited by 34 · see citing works
Su, Z., Yin, J., Wang, T., Sun, Y., Ni, P., Ma, R., Zhu, H., Zheng, D., Shen, H., Xu, W., et al. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12324 · Cited by 33 · see citing works
Kongpol, K., Nernpermpisooth, N., Prompunt, E., & Kumphune, S. (2019) · Biomolecules · doi:10.3390/biom9110678 · Cited by 32 · see citing works
Lee, A., Wang, G., Chan, H., Chen, F.-Y., Chang, C., Yang, C.-Y., Lee, Y., Chang, K., & Chen, C. (2012) · APOPTOSIS · doi:10.1007/s10495-012-0726-1 · Cited by 31 · see citing works
Self-citationMcCormick, M. E., Collins, C., Makarewich, C. A., Chen, Z., Rojas, M., Willis, M. S., Houser, S. R., & Tzima, E. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.114.001210 · Cited by 30 · see citing works
Yu, M., Hu, J., Zhu, M., Zhao, T., Liang, W. H., Wen, S., Li, H., Long, Q., Wang, M., Guo, H.-P., et al. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000356581 · Cited by 28 · see citing works
Werk, D., Pinkert, S., Heim, A., Zeichhardt, H., Grunert, H., Poller, W. C., Erdmann, V. A., Fechner, H., & Kurreck, J. (2009) · Antiviral Research · doi:10.1016/j.antiviral.2009.07.002 · Cited by 27 · see citing works
Crosstalk Between Dermal Fibroblasts and Dendritic Cells During Dengue Virus Infection
Montes-Gómez, A. E., García‐Cordero, J., Marcial‐Juárez, E., Shrivastava, G., Visoso-Carvajal, G., Juárez-Delgado, F. J., Flores‐Romo, L., Sánchez‐Torres, C., Santos‐Argumedo, L., Bustos‐Arriaga, J., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.538240 · Cited by 23 · see citing works
Fulminant Coxsackieviral Myocarditis
Seong, I. W., Choe, S.-C., & Jeon, E. (2001) · New England Journal of Medicine · doi:10.1056/nejm200108023450518 · Cited by 23 · see citing works
Metabolites of Hypoxic Cardiomyocytes Induce the Migration of Cardiac Fibroblasts
Shi, H., Zhang, X., He, Z., Wu, Z., Rao, L.-Y., & Li, Y. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000456531 · Cited by 22 · see citing works
Thelemann, C., Haller, S., Błyszczuk, P., Kania, G., Rosa, M., Eriksson, U., Rotman, S., Reith, W., & Acha‐Orbea, H. (2015) · European Journal of Immunology · doi:10.1002/eji.201545945 · Cited by 21 · see citing works
McDouall, R. M., Farrar, M. W., Khan, S., Yacoub, M. H., & Allen, S. P. (2001) · Endothelium · doi:10.3109/10623320109063155 · Cited by 20 · see citing works
Hirasawa, M., Ito, Y., Shibata, M., & Otsuki, Y. (2006) · International Archives of Allergy and Immunology · doi:10.1159/000095996 · Cited by 18 · see citing works
Funke, C., Farr, M., Werner, B., Dittmann, S., Überla, K., Piper, C., Niehaus, K., & Horstkotte, D. (2010) · Journal of General Virology · doi:10.1099/vir.0.020065-0 · Cited by 18 · see citing works
Effect of lovastatin on coxsackievirus B3 infection in human endothelial cells
Werner, B., Dittmann, S., Funke, C., Überla, K., Piper, C., Niehaus, K., Horstkotte, D., & Farr, M. (2013) · Inflammation Research · doi:10.1007/s00011-013-0695-z · Cited by 17 · see citing works
da Silva, A. R., Neri, E. A., Turaça, L. T., Dariolli, R., Fonseca‐Alaniz, M. H., Santos‐Miranda, A., Roman‐Campos, D., Venturini, G., & Krieger, J. E. (2020) · Scientific Reports · doi:10.1038/s41598-020-73159-0 · Cited by 17 · see citing works
Cao, Y., Wang, Y., Ling Zhi, X. I. A. O., Xu, J., Liu, Y., Jiang, R., Li, T., & Jiang, J. (2021) · PubMed Central · Cited by 16 · see citing works
Targeting Matrix Metalloproteinase Activity and Expression for the Treatment of Viral Myocarditis
Hendry, R. G., Bilawchuk, L. M., & Marchant, D. (2013) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-013-9528-2 · Cited by 14 · see citing works
Koleini, N., Santiago, J., Nickel, B. E., Sequiera, G. L., Wang, J., Fandrich, R. R., Jassal, D. S., Dhingra, S., Kirshenbaum, L. A., Cattini, P. A., et al. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00587.2018 · Cited by 13 · see citing works
Aránguiz, P., Romero, P., Vásquez, F., Flores-Vergara, R., Aravena, D., Sánchez, G., González, M. J., Olmedo, I., & Pedrozo, Z. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165986 · Cited by 13 · see citing works
Rehren, F., Ritter, B. C., Dittrich‐Breiholz, O., Henke, A., Lam, E., Kati, S., Kracht, M., & Heim, A. (2012) · Medical Microbiology and Immunology · doi:10.1007/s00430-012-0245-2 · Cited by 13 · see citing works
Endothelial cell modulation of cardiomyocyte gene expression
Jiang, F., Mohr, F., Ullrich, N. D., Hecker, M., & Wagner, A. H. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.111565 · Cited by 13 · see citing works
Vascular Endothelial Integrity Affects the Severity of Enterovirus-Mediated Cardiomyopathy
Park, J., Shin, H.-H., Rhyu, H.-S., Kim, S., Jeon, E., & Lim, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063053 · Cited by 11 · see citing works
Prochorec‐Sobieszek, M., Bilińska, Z. T., Grzybowski, J., Mazurkiewicz, Ł., Skwarek, M., Walczak, E., Michalak, E., Cedro, K., Chmielak, Z., Dębski, A., et al. (2006) · PubMed · Cited by 10 · see citing works
House Dust Mite Specific Antibodies induce Neutrophilic Inflammation in the Heart
Chen, X., Zhang, Y., Ye, D., Yang, G., Song, Y., Mo, L., Yang, P., & Song, J. (2020) · Theranostics · doi:10.7150/thno.47134 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Immune responses in checkpoint myocarditis across heart, blood and tumour
Blum, S. M., Zlotoff, D. A., Smith, N. P., Kernin, I., Ramesh, S., Zubiri, L., Caplin, J., Samanta, N., Martin, S., Wang, M., et al. (2024) · Nature · doi:10.1038/s41586-024-08105-5 · Cited by 96 · see citing works
Myocarditis: Etiology, Pathogenesis, and Their Implications in Clinical Practice
Brociek, E., Tymińska, A., Giordani, A. S., Caforio, A. L. P., Wojnicz, R., Grabowski, M., & Ozierański, K. (2023) · Biology · doi:10.3390/biology12060874 · Cited by 69 · see citing works
Immunopathogenesis and immunomodulatory therapy for myocarditis
He, W., Zhou, L. D., Xu, K., Li, H., Wang, J. J., Chen, C., & Wang, D. W. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2273-3 · Cited by 55 · see citing works
Self-citationFabry Disease: Cardiac Implications and Molecular Mechanisms
Weissman, D., Dudek, J., Sequeira, V., & Maack, C. (2024) · Current Heart Failure Reports · doi:10.1007/s11897-024-00645-1 · Cited by 31 · see citing works
Duan, X., Zhang, L., Liu, K., Guo, K., You, Y., Jia, H., Zhou, S., & Han, B. (2025) · Biology Direct · doi:10.1186/s13062-025-00621-2 · Cited by 19 · see citing works
Engineered human cardiac tissues for modeling heart diseases
Min, S., & Cho, S. (2022) · BMB Reports · doi:10.5483/bmbrep.2022-0185 · Cited by 16 · see citing works
Tashima, T. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17111365 · Cited by 15 · see citing works
Wang, Y.-E., Chen, J., Yang, H. S., He, J., Varier, K. M., Chen, Y., Wu, X., Guo, Q., Liang, Y., Shen, X., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135970 · Cited by 10 · see citing works
Samal, S., Sahoo, S. P., & Acharya, B. (2025) · Nano Trends · doi:10.1016/j.nwnano.2025.100155 · Cited by 10 · see citing works
Li, S., Tajiri, K., Yuan, Z., Murakata, Y., Song, Z., Mizuno, S., Xu, D., & Murakoshi, N. (2024) · Basic Research in Cardiology · doi:10.1007/s00395-024-01089-3 · Cited by 9 · see citing works
Schiano, C., Balbi, C., de Nigris, F., & Claudio Napoli, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087509 · Cited by 8 · see citing works
Cardiac Macrophages across Space and Time: Roles in Homeostasis, Disease, and Remodeling
Shrestha, S., & Dick, S. A. (2026) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2026.02.025 · Cited by 7 · see citing works
Redox-architected signaling networks in cardiac fibrosis
Zhang, Y., Zhong, Y., Zeng, Q., & Tang, M. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152553 · Cited by 7 · see citing works
He, C., Xu, L., Zhang, Z., & Wang, J. (2025) · PeerJ · doi:10.7717/peerj.20020 · Cited by 7 · see citing works
Phua, T. J. (2023) · Frontiers in Aging · doi:10.3389/fragi.2023.1196648 · Cited by 7 · see citing works
Bheri, S., Hoffman, J., Park, H.-J., Roychowdhury, S., Takaesu, F., Moore, S. G., Gaul, D. A., & Davis, M. E. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1565104 · Cited by 4 · see citing works
Novel Peritoneal Sclerosis Rat Model Developed by Administration of Bleomycin and Lansoprazole
Kunitatsu, K., Yamamoto, Y., Nasu, S., Taniji, A., Kawashima, S., Yamagishi, N., Ito, T., Inoue, S., & Kanai, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216108 · Cited by 4 · see citing works
Kuckelkorn, C., Aksoy, E., Stojanovic, N., Oulahyane, L., Ritter, M., Pfannkuche, K., & Fischer, H. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202403897 · Cited by 3 · see citing works
Fernández-Álvarez, M., Horcajo, P., Jiménez‐Meléndez, A., Lara, P. A., Huertas-López, A., Huertas, F., Ferre, I., Ortega‐Mora, L. M., & Álvarez‐García, G. (2024) · Microorganisms · doi:10.3390/microorganisms12030586 · Cited by 3 · see citing works
Azad, A. J., Bentivogli, A., Germar, H., Wörz, D., Lizunova, E. Y., Cumberland, M. J., Weiner, J. M., & Hedtrich, S. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04537-6 · Cited by 2 · see citing works
Kim, W.-J., Yoon, J. W., Sim, W., Kim, Y. S., Chae, S., Choi, B., Park, H., Kim, J. H., & Kim, G. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.171562 · Cited by 2 · see citing works
Yan, C., Hu, S., Cao, G., & Ma, G. (2026) · Journal of Cardiothoracic Surgery · doi:10.1186/s13019-026-03888-2 · Cited by 2 · see citing works
Firoozabadi, M. D., Nooralishahi, B., & Rezaei‐Tazangi, F. (2026) · Cardiovascular Therapeutics · doi:10.1155/cdr/6182342 · Cited by 2 · see citing works
Liu, W., Qaed, E., Aldahmash, W., Mahyoub, M. A., Hailan, W. A., Alwesabi, A. K., Tang, Z., & Almoiliqy, M. (2026) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2026.110776 · Cited by 2 · see citing works
Arrhythmic Burden After Myocarditis: From Molecular Mechanisms to Therapeutic Strategies
Curcio, A., Romano, L. R., Rocca, C., Lopes, G. T. A., & Quarta, R. (2026) · European Cardiology Review · doi:10.15420/ecr.2025.52 · Cited by 2 · see citing works
Huang, J., Xu, X., Jin, Y., Qiao, L. J., Yu, H., Gao, W., & Li, C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1752354 · Cited by 2 · see citing works
Antiviral innate immunity in myocarditis: mechanisms and emerging therapeutics
Hammons, C., Mohanram, A., Nguyen, P. T., Lu, W., Jacobs, B., Li, X. C., Zhang, Z., & Xing, J. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01822-z · Cited by 2 · see citing works
Sosnowski, D. K., Hébert, T. E., Dobrev, D., & Nattel, S. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100129 · Cited by 1 · see citing works
Liu, R., Feng, X., Ji, H., Shan, Y., Cao, R., & Xu, L. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119349 · Cited by 1 · see citing works
Turan, B., Atıcı, Y., & Billur, D. (2025) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2025-0184 · Cited by 1 · see citing works
Zhou, Y., Chen, H., Feng, Y., Cheng, W., & Wang, Y. (2026) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2026.105032 · Cited by 1 · see citing works
Миндзів, К. В., & Yarema, N. (2023) · Actual problems of modern medicine · doi:10.26565/2617-409x-2023-11-05
(2023) · Actual problems of modern medicine · doi:10.26565/2617-409x-2023-11
AI-targeted drug replenishment in cardiac matrix remodeling and regeneration
Kommeri, R., & Rajalekshmi, R. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40441-2.00008-1
- Authors
- Xuan, Y., Chen, C., Wen, Z., & Wang, D. W.
- Affiliations
- Tongji Hospital (CN)
- Corresponding author
- Wang, Dao Wen
- Venue
- Frontiers in Cardiovascular Medicine
- Publisher
- Frontiers Media SA
- Published
- 2022-04-07
- Volume
- 9
- Pages
- 882027-882027
- ISSN
- 2297-055X (ISSN-L)
- PMC
- PMC9022788
- OpenAlex
- W4226201280
- Cited by
- 35
- References
- 105
- Citations by year
- 2026: 11 · 2025: 10 · 2024: 5 · 2023: 8 · 2022: 1
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Cardiovascular Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81630010, 81790624, 82070395)
- Natural Science Foundation of Hubei Province (2020CFA016)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Keywords
- myocarditis, cardiac fibroblasts, endothelial cells, cardiomyocytes, inflammation, immune cell interactions, cardiac microenvironment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
