The DOI matches its Crossref record; 65 of the 67 references it cites were found in a registry or an index.
The Heavy Burden of Psychiatric Comorbidity in Youth with Autism Spectrum Disorders: A Large Comparative Study of a Psychiatrically Referred Population
Abstract
The objective of the study was to systematically examine patterns of psychiatric comorbidity in referred youth with autism spectrum disorders (ASD) including autistic disorder and pervasive developmental disorder not otherwise specified. Consecutively referred children and adolescents to a pediatric psychopharmacology program were assessed with structured diagnostic interview and measures of psychosocial functioning. Comparisons were made between those youth satisfying diagnostic criteria for ASD and age and sex matched youth without ASD referred to the same clinical program. 9.3% (217/2323) of the referred youth (age range: 3-17 years) met DSM-III-R criteria for ASD. ASD youth suffered from significantly higher number of comorbid disorders than comparisons (6.4 ± 2.7 vs. 5.2 ± 2.9; p < 0.001). Ninety-five percent of the youth with ASD had three or more comorbid psychiatric disorders and 74% had five or more comorbid disorders. ASD youth were also more functionally impaired and required extra-assistance in school and therapeutic interventions at higher rates than age and sex matched non-ASD referred youth. Youth with ASD have high levels of psychiatric comorbidity and dysfunction comparable to the referred population of youth without ASD. These findings emphasize the heavy burden of psychiatric comorbidity afflicting youth with ASD and may be important targets for intervention.
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“Although this may be due to the small number of ASD studies (n = 6), it may also be due to high-comorbidity shared between both disorders (e.g., Joshi et al. 2010).”
From A meta-analytic review of the efficacy of physical exercise interventions on cognition in individuals with autism spectrum disorder and ADHD (2016) · cites this paper as Joshi et al. 2010
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Lai, M.-C., Kassee, C., Besney, R., Bonato, S., Hull, L., Mandy, W., Szatmari, P., & Ameis, S. H. (2019) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30289-5 · Cited by 1,892
Lord, C., Brugha, T. S., Charman, T., Cusack, J., Dumas, G., Frazier, T., Jones, E. J. H., Jones, R. M., Pickles, A., State, M. W., et al. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0138-4 · Cited by 1,859
Identification, Evaluation, and Management of Children With Autism Spectrum Disorder
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The health status of adults on the autism spectrum
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The Role of Emotion Regulation in Autism Spectrum Disorder
Mazefsky, C. A., Herrington, J., Siegel, M., Scarpa, A., Maddox, B. B., Scahill, L., & White, S. W. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.05.006 · Cited by 881
Metadata
- Authors
- Joshi, G., Petty, C., Wozniak, J., Henin, A., Fried, R., Galdo, M., Kotarski, M., Walls, S., & Biederman, J.
- Affiliations
- Harvard University (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Joshi, Gagan
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2010-03-23
- Volume
- 40
- Issue
- 11
- Pages
- 1361-1370
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- OpenAlex
- W2058684270
- Cited by
- 464
- References
- 67
- Citations by year
- 2026: 15 · 2025: 17 · 2024: 30 · 2023: 28 · 2022: 37 · 2021: 48 · 2020: 47 · 2019: 40 · 2018: 32 · 2017: 37 · 2016: 20 · 2015: 37 · 2014: 25 · 2013: 21 · 2012: 19
- FWCI
- 9.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centers for Disease Control and Prevention
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- autism spectrum disorder, psychiatric comorbidity, pervasive developmental disorder not otherwise specified, autistic disorder, children and adolescents, psychosocial functioning, functional disability, therapeutic interventions, psychiatric referral, pediatric psychopharmacology
- MeSH terms
- Adolescent, Autistic Disorder, Mental Disorders, Child, Child Development Disorders, Pervasive, Child, Preschool, Female, Humans, Male, Psychiatric Status Rating Scales, Referral and Consultation, Comorbidity, Case-Control Studies, Cost of Illness, Diagnostic and Statistical Manual of Mental Disorders
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