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Excess mortality and causes of death in autism spectrum disorders: a follow up of the 1980s Utah/UCLA autism epidemiologic study.
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This study's purpose was to investigate mortality among individuals with autism spectrum disorders (ASD) ascertained during a 1980s statewide autism prevalence study (n = 305) in relation to controls. Twenty-nine of these individuals (9.5 %) died by the time of follow up, representing a hazard rate ratio of 9.9 (95 % CI 5.7-17.2) in relation to population controls. Death certificates identified respiratory, cardiac, and epileptic events as the most common causes of death. The elevated mortality risk associated with ASD in the study cohort appeared related to the presence of comorbid medical conditions and intellectual disability rather than ASD itself suggesting the importance of coordinated medical care for this high risk sub-population of individuals with ASD.
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“several studies13,14,15,16,17,18,19 have suggested that persons with ASD or ADHD may be associated with an increased risk of mortality; however, the results are inconsistent.”
From Mortality in Persons With Autism Spectrum Disorder or Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-analysis (2022) · cites this paper as [14]
In the citing paper
“several studies13,14,15,16,17,18,19 have suggested that persons with ASD or ADHD may be associated with an increased risk of mortality; however, the results are inconsistent.”
From Mortality in Persons With Autism Spectrum Disorder or Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-analysis (2022) · cites this paper as [14]
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Metadata
- Authors
- Bilder, D., Botts, E. L., Smith, K. R., Pimentel, R., Farley, M., Viskochil, J., McMahon, W. M., Block, H., Ritvo, E., Ritvo, R.-A., & Coon, H.
- Affiliations
- University of Utah (US)
- University of California, Los Angeles (US)
- Yale University (US)
- Corresponding author
- Bilder, Deborah
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2012-09-25
- Volume
- 43
- Issue
- 5
- Pages
- 1196-1204
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- PMC
- PMC4814267
- OpenAlex
- W2096889758
- Cited by
- 116
- References
- 31
- Citations by year
- 2026: 9 · 2025: 2 · 2024: 10 · 2023: 8 · 2022: 13 · 2021: 7 · 2020: 14 · 2019: 16 · 2018: 4 · 2017: 8 · 2016: 10 · 2015: 8 · 2014: 4 · 2013: 3
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Autism Speaks
- University of Utah
- Huntsman Cancer Foundation
- Centers for Disease Control and Prevention
- National Institute on Aging (R01AG022095)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- autism spectrum disorder, excess mortality, causes of death, comorbidities, intellectual disability, respiratory diseases, heart disease, epilepsy, mortality risk, follow-up cohort
- MeSH terms
- Adolescent, Adult, Cause of Death, Child, Child Development Disorders, Pervasive, Child, Preschool, Death Certificates, Female, Follow-Up Studies, Humans, Male, Utah, Survival Analysis, Databases, Factual
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