Telomere length is short in PCOS and oral contraceptive does not affect the telomerase activity in granulosa cells of patients with PCOS
Open accessAbstract
Purpose Our study aimed to investigate the association of telomerase activity (TA) and telomere length (TL) in granulosa cells (GCs) with IVF outcomes of polycystic ovary syndrome (PCOS) patients, and the effects of oral contraceptive pill (OCP) pretreatment on these two parameters.Methods One hundred sixty-three infertile women were enrolled and divided into a PCOS group (n = 65) and a non-PCOS group (n = 98). The PCOS group was further divided into an OCP pretreatment group (n = 35) and a non-OCP pretreatment group (n = 30), a TA <0.070 group (n = 34) and a TA ≥0.070 group (n = 31), and a TL <1 group (n = 41) and a TL ≥1 group (n = 24), respectively.Results No obvious differences were observed in TA between these groups. The TL was 0.971 in PCOS group and 1.118 in non-PCOS group (P = 0.005). The patients with TL ≥1 accounted for 36.9% in PCOS group and 54.1% in non-PCOS group (P = 0.032). The average duration of infertility for PCOS patients was 5 years in TA <0.070 group and 4 years in TA ≥0.070 group (P = 0.038), and 5 years in TL <1 group and 3 years in TL ≥1 group (P = 0.006), respectively. No obvious differences were observed in IVF outcomes between these groups. No obvious differences were observed in TA, TL, or IVF outcomes between OCP pretreatment group and non-OCP pretreatment group in PCOS patients.Conclusions Shorter TL was found in PCOS patients. The TA levels did not change significantly in PCOS patients. PCOS patients with a lower TA level and shorter telomeres had an earlier onset of infertility symptoms. No predictive value was found for TA and TL in terms of embryo quality or IVF outcomes in PCOS patients, and no effect OCP pretreatment was observed on either TA and TL.
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Among women undergoing IVF, those with polycystic ovary syndrome who have low telomerase activity and short granulosa cell telomeres show earlier onset of infertility.
“patients with polycystic ovary syndrome with low telomerase activity and short telomeres in granulosa cells, which support oocyte maturation, show an earlier onset of infertility178”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [178]
Telomere shortening is associated with reduced fertility in several ways.
“Telomere shortening has been associated with reduced fertility in several ways177–180.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [178]
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Telomere dysfunction in ageing and age-related diseases
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- Authors
- Li, Y., Deng, B., Ouyang, N., Yuan, P., Zheng, L., & Wang, W.
- Affiliations
- Sun Yat-sen University (CN)
- Xiamen Maternal and Child Health Hospital (CN)
- Corresponding author
- Wang, Wenjun
- Venue
- Journal of Assisted Reproduction and Genetics
- Published
- 2017-05-06
- Volume
- 34
- Issue
- 7
- Pages
- 849-859
- ISSN
- 0740-7769 (ISSN-L)
- 1058-0468
- 1573-7330
- PMC
- PMC5476543
- OpenAlex
- W2610489783
- Cited by
- 32
- References
- 37
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 5
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Assisted Reproduction and Genetics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- the Medical Scientific Research Foundation of Guangdong Province (A2015143)
- the Natural Science Foundation of Guangdong Province (2015A030313086)
- the Science and Technology Planning Project of Guangdong Province (2014A020213014)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- polycystic ovary syndrome, telomere length, telomerase activity, granulosa cells, oral contraceptive pretreatment, IVF outcomes, female infertility, embryo quality, telomere shortening
- MeSH terms
- Adult, Contraceptives, Oral, Female, Fertilization in Vitro, Granulosa Cells, Humans, Infertility, Female, Polycystic Ovary Syndrome, Retrospective Studies, Treatment Outcome, Telomerase, Telomere Homeostasis
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