Embryoscopy and karyotype findings of repeated miscarriages in recurrent pregnancy loss and spontaneous pregnancy loss
Open accessAbstract
Purpose The aim of the study was to assess cytogenetic and embryoscopic characteristics in subsequent miscarriages of spontaneous pregnancy losses (SPL) and recurrent pregnancy losses (RPL).Methods A retrospective cohort of 75 women was affected by repeated pregnancy loss. Of those, 34 had SPL, 24 primary RPL, and 17 secondary RPL. Ploidy status and morphology was analyzed by transcervical embryoscopic examination of the embryo and cytogenetic analysis of the chorionic villi in subsequent miscarriages.Results Similar rates of recurrent ploidy status were observed between first and second miscarriage in SPL and RPL (82.4% recurrent ploidy status in SPL, p > 0.999; 73% recurrent ploidy status in RPL, p = 0.227). No difference was found regarding recurrent abnormal morphology between SPL and RPL (p = 0.092). However, secondary RPL resulted significantly more often in recurrent abnormal morphology compared to primary RPL (p = 0.004).Conclusions High rates of recurrent normal/abnormal karyotypes were observed in all groups with a majority of embryos presenting with recurrent abnormal morphology. Secondary RPL presented significantly more often with recurrent abnormal morphology compared to primary RPL. These findings offer prognostic information for the affected patient and might impact treatment choice.
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Alcohol use is an important modifiable risk factor for miscarriage.
“Our literature review found that alcohol use is also an important modifiable risk factor, as high alcohol consumption during the first trimester is associated with an increase in miscarriage risk (aOR 1·67; 95% CI 1·31-2·19; Table 6). 25,39,62-70”
From Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss (2021) · cites this paper as [39]
The Introduction discusses genetic causes of miscarriage and possible maternal factors, but does not mention alcohol. Searches for alcohol use, first-trimester alcohol consumption, and the reported odds ratio found no passage in our copy addressing the claimed association. (LLM, conf=0.76)
Experimental — accuracy not yet measuredHigh alcohol consumption during the first trimester is associated with an increase in miscarriage risk (aOR 1.67; 95% CI 1.31-2.19).
“Our literature review found that alcohol use is also an important modifiable risk factor, as high alcohol consumption during the first trimester is associated with an increase in miscarriage risk (aOR 1·67; 95% CI 1·31-2·19; Table 6). 25,39,62-70”
From Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss (2021) · cites this paper as [39]
The Methods describe embryoscopic and cytogenetic evaluation of first-trimester miscarriages, not an analysis of alcohol exposure. Searches for first-trimester alcohol consumption, miscarriage risk, and the reported aOR and confidence interval found no passage addressing the claimed association. (LLM, conf=0.76)
Experimental — accuracy not yet measuredHigh caffeine intake might be associated with miscarriage (aOR 1.56; 95% CI 0.98-2.50), although there was statistical uncertainty.
“Our review indicated that high caffeine intake might be associated with miscarriage (aOR 1·56; 95% CI 0.98-2·50; Table 6), although there was statistical uncertainty in the finding. 25,39,71”
From Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss (2021) · cites this paper as [39]
The Introduction discusses genetic causes and possible maternal factors in miscarriage, while the Discussion addresses embryoscopic and karyotype findings; neither addresses caffeine intake. Searches for caffeine, coffee, and the reported aOR and confidence interval found no passage supporting the claimed association. (LLM, conf=0.77)
Experimental — accuracy not yet measured
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- Authors
- Feichtinger, M., Reiner, A., Hartmann, B., & Philipp, T.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Philipp, T.
- Venue
- Journal of Assisted Reproduction and Genetics
- Published
- 2018-06-18
- Volume
- 35
- Issue
- 8
- Pages
- 1401-1406
- ISSN
- 0740-7769 (ISSN-L)
- 1058-0468
- 1573-7330
- PMC
- PMC6086789
- OpenAlex
- W2809668366
- Cited by
- 18
- References
- 24
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 1
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Assisted Reproduction and Genetics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
- Keywords
- recurrent pregnancy loss, spontaneous pregnancy loss, embryo biopsy, embryo ploidy, embryo morphology, embryo abnormalities
- MeSH terms
- Abortion, Spontaneous, Abortion, Habitual, Abortion, Induced, Adult, Chromosome Aberrations, Cytogenetics, Female, Fetoscopy, Humans, Pregnancy, Cohort Studies, Karyotype
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