The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Preparation and characterization of amidated pectin based hydrogels for drug delivery system
Abstract
In the current studies attempts were made to prepare hydrogels by chemical modification of pectin with ethanolamine (EA) in different proportions. Chemically modified pectin products were crosslinked with glutaraldehyde reagent for preparing hydrogels. The hydrogels were characterized by Fourier transform infrared spectroscopy (FTIR), organic elemental analysis, X-ray diffraction studies (XRD), swelling studies, biocompatibility and hemocompatibility studies. Mechanical properties of the prepared hydrogels were evaluated by tensile test. The hydrogels were loaded with salicylic acid (used as a model drug) and drug release studies were done in a modified Franz's diffusion cell. FTIR spectroscopy indicated the presence of primary and secondary amide absorption bands. XRD studies indicated increase in crystallinity in the hydrogels as compared to unmodified pectin. The degree of amidation (DA) and molar and mass reaction yields (YM and YN) was calculated based on the results of organic elemental analysis. The hydrogels showed good water holding properties and were found to be compatible with B-16 melanoma cells & human blood.
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“While AP has been studied as a potential carrier for colon-specific drug delivery, such systems often rely on calcium ion crosslinking [20,27].”
From Amidated Pectin/Nanocellulose Hybrid Cryogel System with a pH-Responsive Release Profile for Small Intestinal Delivery (2025) · cites this paper as [27]
Citations
Cites
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Self-citationComplex Coacervate Microcapsules for Mammalian Cell Culture and Artificial Organ Development
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- R. RADAI and A. RUBENSTEIN, Proc. Int. Symp, control Release, Bioact. Mater. 20 (1993) 310
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Feng, S., Laurén, P., Zini, J., Gounani, Z., Bi, J., Yi, J., & Laaksonen, T. (2025) · Gels · doi:10.3390/gels11090700 · Cited by 5
“To date, AP has been explored as a potential drug carrier for colon-specific drug delivery but often requires the assistance of calcium ions [20,27].”
Metadata
- Authors
- Mishra, R. K., Datt, M., Pal, K., & Banthia, A. K.
- Affiliations
- Bundelkhand University (IN)
- Indian Institute of Technology Kharagpur (IN)
- Corresponding author
- Banthia, A. K.
- ORCID
- Venue
- Journal of Materials Science Materials in Medicine
- Published
- 2007-12-06
- Volume
- 19
- Issue
- 6
- Pages
- 2275-2280
- ISSN
- 0957-4530 (ISSN-L)
- 1573-4838
- OpenAlex
- W2057671175
- Cited by
- 99
- References
- 11
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 14 · 2023: 6 · 2022: 10 · 2021: 9 · 2020: 9 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Materials Science Materials in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- amidated pectin, pectin hydrogels, monoethanolamine, glutaraldehyde crosslinking, drug delivery, salicylic acid, drug release, swelling behavior, biocompatibility, hemocompatibility, mechanical properties, B16 melanoma, crystallinity
- MeSH terms
- Amides, Animals, Biocompatible Materials, Blood, Humans, Kinetics, Melanoma, Experimental, Pectins, Tetrazolium Salts, Thiazoles, Wound Healing, X-Ray Diffraction, Drug Delivery Systems, Spectroscopy, Fourier Transform Infrared, Hydrogel, Polyethylene Glycol Dimethacrylate, Mice
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