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Cited by 30Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsBRCA gene mutations in cancer

Perceptions of Familial Risk in those Seeking a Genetic Risk Assessment for Alzheimer's Disease

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Hiraki, Susan, Chen, Clara A., Roberts, J. Scott, Cupples, L. Adrienne, Green, Robert C.·2009·Journal of Genetic Counseling
DOI 10.1007/s10897-008-9194-8PMC PMC2919070
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Abstract

Perceived risk is a complex concept that influences the genetic counseling process and can affect client coping and behavior. Although the association between family history and risk perception is well recognized in the literature, no studies have explored this relationship specifically in those seeking genetic susceptibility testing for a common chronic condition. REVEAL is a randomized trial assessing the impact of APOE disclosure and genetic risk assessment for Alzheimer's disease (AD). Using baseline REVEAL data, we hypothesized that there would be a significant association between the degree of AD family history and risk perception of AD, and that this relationship would be stronger in those who believed that genetics is a very important AD risk factor. In our sample of 293 participants, we found that a higher self‐perceived risk of AD was associated with strength of family history of AD (p < 0.001), belief in genetics as an important AD risk factor (p < 0.001), being female (p < 0.001) and being Caucasian (p = 0.02). These results are the first to demonstrate the association between family history and risk perception in persons volunteering for genetic susceptibility testing for a common complex disease.

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  • Studies on genetic susceptibility testing for Alzheimer's disease show a strong association between family history and genetic risk factors and self-perceived risk of the disease.

    “Similarly, studies on genetic susceptibility testing for AD have shown that there is a strong association between family history and genetic risk factor for AD on self-perceived risk of the disease (Hiraki, Chen, Roberts, Cupples, & Green, 2008; Larusse et al., 2005).”

    From Correlates of dementia-related anxiety: self-perceived dementia risk and ageism (2020) · cites this paper as Hiraki, Chen, Roberts, Cupples, & Green, 2008

    The Results (Risk Perception Analyses; page not provided) report that family history and belief in genetics as an AD risk factor were significant predictors of perceived risk among people seeking genetic testing. The paper measured belief in genetics, not an actual genetic risk factor, and found no evidence that this belief strengthened the association between family history and perceived risk. (LLM, conf=0.85)

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Cited by

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Authors
Hiraki, S., Chen, C. A., Roberts, J. S., Cupples, L. A., & Green, R. C.
Affiliations
  • Boston University (US)
  • University of Michigan (US)
Corresponding author
Hiraki, Susan
ORCID
Venue
Journal of Genetic Counseling
Publisher
Wiley
Published
2008-10-23
Volume
18
Issue
2
Pages
130-136
ISSN
  • 1059-7700 (ISSN-L)
  • 1573-3599
DOI
10.1007/s10897-008-9194-8
PMC
PMC2919070
OpenAlex
W2053334580
Cited by
30
References
2
Citations by year
2026: 1 · 2024: 1 · 2023: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 6
FWCI
0.89
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Genetic Counseling (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Deep Blue (University of Michigan) (submittedVersion)
Funders
National Institutes of Health (R01 HG02213, R01 AG09029, P30 AG13846, M01 RR00533)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Keywords
Alzheimer's disease, risk perception, family history (medicine), genetic risk prediction, genetic susceptibility testing, genetic counseling, sex differences, racial differences
MeSH terms
Alzheimer Disease, Family, Female, Humans, Male, Risk Assessment, Genetic Predisposition to Disease

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