CoChat
Sign Up
Cited by 45

The DOI matches its Crossref record.

Tsc-22 enhances TGF-? signaling by associating with Smad4 and induces erythroid cell differentiation

Choi, So-Jung, Moon, Jae-Hoon, Ahn, Young-Wook, Ahn, Jin-Hyun, Kim, Dong-Uk, Han, Tae-Hee·2005·Molecular and Cellular Biochemistry
DOI 10.1007/s11010-005-3456-7
Open this paper in CoChat — free account

Abstract

Tsc-22 was isolated as a TGF-beta-inducible gene by differential screening of the mouse osteoblastic cell cDNA library [J Biol Chem 267 (1992) 10219]. tsc-22 mRNA is expressed in almost all organs of mice and humans and its expression is induced in a variety of cell lines by many different factors including TGF-beta, phorbol ester, serum, and progestin. tsc-22 encodes a 18-kd protein that contains a leucine zipper motif and a Tsc-box. The leucine zipper motif of the Tsc-22 protein does not have a basic DNA binding motif and when the protein was fused to a heterologous DNA binding domain, it showed various transcription-modulating activities ranging from activation to repression [J Biol Chem 274 (1999) 27439, Biochem Biophys Res Commun 278 (2000) 659]. Although these results suggest that the Tsc-22 protein functions as a transcriptional regulator recruiting various coactivators or repressors, its mechanism is not known. In this study, we examined whether Tsc-22 modulates the TGF-beta-dependant signaling pathway and found that Tsc-22 binds to and modulate the transcriptional activity of Smad3 and Smad4. Its effect on cellular differentiation was also examined.

Overview

Integrity signals

Registry

Crossref · 10.1007/s11010-005-3456-7

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 22

  1. Shibanuma M, Kuroki T, Nose K: Isolation of a gene encoding a putative leucine zipper structure that is induced by transforming growth factor beta 1 and other growth factors. J Biol Chem 267: 10219?10224, 1992 · DOI
  2. Kester HA, Blanchetot C, den Hertog J, van der Saag PT, van der Burg B: Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine-zipper proteins that can homodimerize and heterodimerize and has transcriptional repressor activity. J Biol Chem 274: 27439?27447, 1999 · DOI
  3. Hino S, Kawamata H, Uchida D, Omotehara F, Miwa Y, Begum NM, Yoshida H, Fujimori T, Sato M: Nuclear translocation of Tsc-22 concomitant with apoptosis: Tsc-22 as a putative transcriptional regulator. Biochem Biophys Res Commun 278: 659?664, 2000 · DOI
  4. Massague J, Wotton D: Transcriptional control by the TGF-?/Smad signaling system. EMBO J 19: 1745?1754, 2000 · DOI
  5. Itoh S, Itoh F, Goumans M, ten Dijke P: Signaling of transforming growth factor-? family members through Smad proteins. Eur J Biochem 267: 6954?6967, 2000 · DOI
  6. Oft M, Peli J, Rudaz C, Schwartz H, Beug H, Reichmann E: Tgf-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumors. Genes Dev 10: 2462?2477, 1996 · DOI
  7. Feng XH, Zhang Y, Wu RY, Derynck R: The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation. Genes Dev 12: 2153?2163, 1998 · DOI
  8. Janknecht R, Wells NJ, Hunter T: TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. Genes Dev 12: 2144?2119, 1998 · DOI
  9. Nishihara A, Hanai J, Okamoto N, Yanagisawa J, Kato S, Miyazono K, Kawabata M: Role of p300, a transcriptional coactivator, in signalling of TGF-beta. Genes Cells 3: 613?623, 1998 · DOI
  10. Pouponnot C, Jayaraman L, Massague J: Physical and functional interaction of SMADs and p300/CBP. J Biol Chem 273: 22865?22868, 1998 · DOI
  11. Shen X, Hu PP, Liberati NT, Datto MB, Frederick JP, Wang XF: TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein. Mol Biol Cell 9: 3309?3319, 1998 · DOI
  12. Topper JN, DiChiara MR, Brown JD, Williams AJ, Falb D, Collins T, Gimbrone MA, Jr: CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells. Proc Natl Acad Sci USA 95: 9506?9511, 1998 · DOI
  13. Wotton D, Lo RS, Lee S, Massague J: A Smad transcriptional corepressor Cell 97: 29?39, 1999 · DOI
  14. Akiyoshi S, Inoue H, Hanai J, Kusanagi K, Nemoto N, Miyazono K, Kawabata M: c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads. J Biol Chem 274: 35269?35277, 1999 · DOI
  15. Luo K, Stroschein SL, Wang W, Chen D, Martens E, Zhou S, Zhou Q: The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling. Genes Dev 13: 2196?2206, 1999 · DOI
  16. Sun Y, Liu X, Eaton EN, Lane WS, Lodish HF, Weinberg RA: Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling. Mol Cell 4: 499?509, 1999 · DOI
  17. Stroschein SL, Wang W, Zhou S, Zhou Q, Luo K: Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein. Science 286: 771?774, 1999 · DOI
  18. Vogel P, Magert HJ, Cieslak A, Adermann K, Forssmann WG: hDIP?A potential transcriptional regulator related to murine TSC-22 and Drosophila shortsighted (shs)?is expressed in a large number of human tissues. Biochim Biophys Acta 1309: 200?204, 1996 · DOI
  19. Treisman JE, Lai ZC, Rubin GM: Shortsighted acts in the decapentaplegic pathway in Drosophila eye development and has homology to a mouse TGF-beta-responsive gene. Development 121: 2835?2845, 1995 · DOI
  20. de Caestecker MP, Yahata T, Wang D, Parks WT, Huang S, Hill CS, Shioda T, Roberts AB, Lechleider RJ: The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain. J Biol Chem 275: 2115?2122, 2000 · DOI
  21. Shin HM, Seoh JY, Chung HY, Choi SJ, Hahn MJ, Kang JS, Choi MS, Han TH: Requirement of MEF2D in the induced differentiation of HL60 promyeloid cells. Mol Immunol 36: 1209?1214, 1999 · DOI
  22. Taketani S, Furukawa T, Furuyama K: Expression of coproporphyrinogen oxidase and synthesis of hemoglobin in human erythroleukemia K562 cells. Eur J Biochem 268: 1705?1711, 2001 · DOI

Cited by

Sorted by citations

Metadata

Authors
Choi, S.-J., Moon, J.-H., Ahn, Y.-W., Ahn, J.-H., Kim, D.-U., & Han, T.-H.
Venue
Molecular and Cellular Biochemistry
Publisher
Springer Science and Business Media LLC
Published
2005-03
Volume
271
Issue
1-2
Pages
23-28
ISSN
  • 0300-8177
  • 1573-4919
DOI
10.1007/s11010-005-3456-7
Cited by
45
References
0
Language
en
Licence
www.springer.com/tdm (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review