Cited by 83MicroRNA in disease regulationExtracellular vesicles in diseaseRNA Research and Splicing

Red Blood Cells as Potential Repositories of MicroRNAs in the Circulatory System

Open access
Sun, Liping, Yu, Yang, Niu, Beifang, Wang, Deqing·2020·Frontiers in Genetics

Abstract

The amount of erythrocyte-derived microRNAs (miRNAs) represents the majority of miRNAs expressed in whole blood. miR-451, miR-144, and miR-486, which are abundant in red blood cells (RBCs), are involved in the process of erythropoiesis and disease occurrence. Moreover, erythrocyte-derived miRNAs have been reported to be potential biomarkers of specific diseases. However, the function and underlying mechanisms of miRNAs derived from erythrocytes remain unclear. Based on a review of previously published literature, we discuss several possible pathways by which RBC miRNAs may function and propose that RBCs may serve as repositories of miRNAs in the circulatory system and participate in the regulation of gene expression mainly via the transfer of miRNAs from erythrocyte extracellular vesicles (EVs). In the whole blood, there are still other important cell types such as leukocytes and platelets harboring functional miRNAs, and hemolysis also exists, which limit the abundance of miRNAs as disease biomarkers, and thus, miRNA studies on RBCs may be impacted. In the future, the role of RBCs in the regulation of normal physiological functions of the body and the entire circulatory system under pathological states, if any, remains to be determined.

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Works this paper cites that were later retracted, from the retraction notices publishers deposit. Major when the notice came out before this paper was published.

  • Cites a retracted work: 10.1002/jcb.26657

    Major

    The cited work was retracted on 2019-04-16 (notice 10.1002/jcb.26657), before this paper was published (2020-06-03). Its authors could have known.

    Cited work 10.1002/jcb.26657 · retracted 2019-04-16 · notice 10.1002/jcb.26657 · this paper published 2020-06-03

  • Cites a retracted work: 10.3389/fimmu.2019.02205

    Info

    The cited work was retracted on 2024-05-13 (notice 10.3389/fimmu.2024.1429708), not before this paper was published (2020-06-03).

    Cited work 10.3389/fimmu.2019.02205 · retracted 2024-05-13 · notice 10.3389/fimmu.2024.1429708 · this paper published 2020-06-03

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Authors
Sun, L., Yu, Y., Niu, B., & Wang, D.
Affiliations
  • Chinese PLA General Hospital (CN)
  • Chinese Academy of Sciences (CN)
Corresponding author
  • Niu, Beifang
  • Wang, Deqing
Venue
Frontiers in Genetics
Published
2020-06-03
Volume
11
Pages
442-442
ISSN
1664-8021 (ISSN-L)
OpenAlex
W3033110452
Cited by
83
References
76
Citations by year
2026: 10 · 2025: 12 · 2024: 14 · 2023: 14 · 2022: 19 · 2021: 11 · 2020: 3
FWCI
1.13
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Genetics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China
  • Natural Science Foundation of Beijing Municipality
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords
erythrocytes, extracellular vesicles, miR-451, miR-144, miR-486, erythropoiesis, disease biomarkers, hemolysis, leukocytes, platelets, cardiovascular system, gene expression regulation

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