Red Blood Cells as Potential Repositories of MicroRNAs in the Circulatory System
Open accessAbstract
The amount of erythrocyte-derived microRNAs (miRNAs) represents the majority of miRNAs expressed in whole blood. miR-451, miR-144, and miR-486, which are abundant in red blood cells (RBCs), are involved in the process of erythropoiesis and disease occurrence. Moreover, erythrocyte-derived miRNAs have been reported to be potential biomarkers of specific diseases. However, the function and underlying mechanisms of miRNAs derived from erythrocytes remain unclear. Based on a review of previously published literature, we discuss several possible pathways by which RBC miRNAs may function and propose that RBCs may serve as repositories of miRNAs in the circulatory system and participate in the regulation of gene expression mainly via the transfer of miRNAs from erythrocyte extracellular vesicles (EVs). In the whole blood, there are still other important cell types such as leukocytes and platelets harboring functional miRNAs, and hemolysis also exists, which limit the abundance of miRNAs as disease biomarkers, and thus, miRNA studies on RBCs may be impacted. In the future, the role of RBCs in the regulation of normal physiological functions of the body and the entire circulatory system under pathological states, if any, remains to be determined.
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Cites a retracted work: 10.1002/jcb.26657
MajorThe cited work was retracted on 2019-04-16 (notice 10.1002/jcb.26657), before this paper was published (2020-06-03). Its authors could have known.
Cited work 10.1002/jcb.26657 · retracted 2019-04-16 · notice 10.1002/jcb.26657 · this paper published 2020-06-03
“Liu, 2018, miR-451 selectively increases sensitivity to cisplatin in ERCC1-high non-small cell lung cancer cells., J. Cell Biochem., 10.1002/jcb.26657”
Cites a retracted work: 10.3389/fimmu.2019.02205
InfoThe cited work was retracted on 2024-05-13 (notice 10.3389/fimmu.2024.1429708), not before this paper was published (2020-06-03).
Cited work 10.3389/fimmu.2019.02205 · retracted 2024-05-13 · notice 10.3389/fimmu.2024.1429708 · this paper published 2020-06-03
“Yao, 2019, Platelet-derived exosomal MicroRNA-25-3p inhibits coronary vascular endothelial cell inflammation through Adam10 via the NF-κB signaling pathway in ApoE−/− Mice., Front. Immunol., 10, 10.3389/fimmu.2019.02205”
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- Authors
- Sun, L., Yu, Y., Niu, B., & Wang, D.
- Affiliations
- Chinese PLA General Hospital (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Niu, Beifang
- Wang, Deqing
- Venue
- Frontiers in Genetics
- Publisher
- Frontiers Media SA
- Published
- 2020-06-03
- Volume
- 11
- Pages
- 442-442
- ISSN
- 1664-8021 (ISSN-L)
- PMC
- PMC7286224
- OpenAlex
- W3033110452
- Cited by
- 83
- References
- 76
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 14 · 2023: 14 · 2022: 19 · 2021: 11 · 2020: 3
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Genetics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- erythrocytes, extracellular vesicles, miR-451, miR-144, miR-486, erythropoiesis, disease biomarkers, hemolysis, leukocytes, platelets, cardiovascular system, gene expression regulation
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