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Cited by 34Heavy Metal Exposure and ToxicityChemotherapy-induced organ toxicity mitigationAntioxidant Activity and Oxidative Stress

Attenuation of oxidative stress, inflammation and early markers of tumor promotion by caffeic acid in Fe-NTA exposed kidneys of Wistar rats

U. Rehman, Muneeb, Sultana, Sarwat·2011·Molecular and Cellular Biochemistry
DOI 10.1007/s11010-011-0881-7
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Abstract

Iron nitrilotriacetate (Fe-NTA), a chief environmental pollutant, is known for its extensive toxic manifestations on renal system. In the present study, caffeic acid, one of the most frequently occurring phenolic acids in fruits, grains, and dietary supplements was evaluated for its shielding effect against the Fe-NTA-induced oxidative, inflammatory, and pathological damage in kidney. Fe-NTA was administered (9 mg Fe/kg body weight) intraperitoneally to the Wistar male rats on 20th day while caffeic acid was administered orally (20 and 40 mg/kg body weight) before administration of Fe-NTA. The intraperitoneal administration of Fe-NTA-enhanced lipid peroxidation, xanthine oxidase, and hydrogen peroxide generation with reduction in renal glutathione content, antioxidant enzymes, viz., catalase, glutathione peroxidase, and glutathione reductase. A sharp elevation in the levels of myloperoxidase, blood urea nitrogen (BUN), and serum creatinine has also been observed. Tumor promotion markers viz., ornithine decarboxylase (ODC) and [(3)H] thymidine incorporation into renal DNA were also significantly increased. Treatment of rats orally with caffeic acid (20 and 40 mg/kg body weight) resulted in a significant decrease in xanthine oxidase (P < 0.001), lipid peroxidation (P < 0.001), γ-glutamyl transpeptidase (P < 0.01), and H(2)O(2) (P < 0.01). There was significant recovery of renal glutathione content (P < 0.001) and antioxidant enzymes (P < 0.001). There was also a reversal in the enhancement of renal ODC activity, DNA synthesis, BUN, and serum creatinine (P < 0.001). All these changes were supported by histological observations. The results indicate that caffeic acid may be beneficial in ameliorating the Fe-NTA-induced oxidative damage and tumor promotion in the kidney of rats.

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  • The disturbed kidney parameters may have been induced by the reduction of phenolic acids in this study.

    “The disturbed kidney parameters may have been induced by the reduction of phenolic acids in our study, since caffeic and ferulic acids are beneficial in the kidney as they prevent oxidative stress (Srinivasan et al., 2005;U Rehman and Sultana, 2011).”

    From RETRACTED: Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize (2012) · cites this paper as U Rehman and Sultana, 2011

  • Caffeic and ferulic acids are beneficial in the kidney as they prevent oxidative stress.

    “The disturbed kidney parameters may have been induced by the reduction of phenolic acids in our study, since caffeic and ferulic acids are beneficial in the kidney as they prevent oxidative stress (Srinivasan et al., 2005;U Rehman and Sultana, 2011).”

    From RETRACTED: Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize (2012) · cites this paper as U Rehman and Sultana, 2011

  • The disturbed kidney functional parameters may have been induced by the reduced levels of phenolic acids in the GM maize feed used in the study, since caffeic and ferulic acids are beneficial to the kidney as they prevent oxidative stress.

    “Therefore, the disturbed kidney functional parameters may have been induced by the reduced levels of phenolic acids in the GM maize feed used in our study, since caffeic and ferulic acids are beneficial to the kidney as they prevent oxidative stress [38,39].”

    From Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerantgenetically modified maize (2014) · cites this paper as [39]

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Authors
U. Rehman, M., & Sultana, S.
Affiliations
Jamia Hamdard (IN)
Corresponding author
Sultana, Sarwat
ORCID
Sultana, Sarwat
Venue
Molecular and Cellular Biochemistry
Publisher
Springer Science and Business Media LLC
Published
2011-06-07
Volume
357
Issue
1-2
Pages
115-124
ISSN
  • 0300-8177 (ISSN-L)
  • 1573-4919
DOI
10.1007/s11010-011-0881-7
OpenAlex
W1992345388
Cited by
34
References
66
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 5
FWCI
3.23
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Molecular and Cellular Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministry of Health and Family Welfare
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Chemotherapy-induced organ toxicity mitigation
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
caffeic acid, nephrotoxicity, oxidative stress, inflammation, tumor promotion, lipid peroxidation, xanthine oxidase, hydrogen peroxide, antioxidant enzymes, glutathione, ornithine decarboxylase, phenolic acids, renal protection
MeSH terms
Animals, Antioxidants, Blood Urea Nitrogen, Caffeic Acids, Creatinine, DNA, Environmental Pollutants, Ferric Compounds, Glutathione, Hydrogen Peroxide, Inflammation, Kidney, Kidney Diseases, Male, Nitrilotriacetic Acid, Thymidine, Lipid Peroxidation, Rats, Wistar, Oxidative Stress, Rats

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