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Cited by 36Respiratory Support and MechanismsSepsis Diagnosis and TreatmentGenetic Associations and Epidemiology

Association of IL-10−1082 G/G genotype with lower mortality of acute respiratory distress syndrome in a Chinese population

Jin, Xiaodong, Hu, Zhi, Kang, Yan, Liu, Chang, Zhou, Yongfang, Wu, Xiaodong, Liu, Jin, Zhong, Mingxing +7 more·2012·Molecular Biology Reports
DOI 10.1007/s11033-010-0377-7
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Abstract

We aimed to investigate whether interleukin-10 (IL-10) -1082 G/G genotype is associated with lower mortality of acute respiratory distress syndrome (ARDS) in a Chinese population. A hospital-based case-control study was conducted in 314 cases of ARDS and 210 controls who were admitted to an intensive care unit with sepsis, trauma, aspiration or massive transfusions. Cases were followed for 30-day mortality. The -1082G/G genotype was associated with lower development of ARDS (OR=0.51; 95% CI 0.34-0.76; P=0.001). Among patients with ARDS, the -1082G/G genotype was associated with lower 30-day mortality (OR=0.44; 95% CI 0.25-0.76; P=0.003). In conclusion, IL-10-1082 G/G genotype is associated with lower development and mortality of ARDS in a Chinese population.

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  • It is known that schizophrenia patients have upregulated genes for inflammatory cytokines, and downregulated Bdnf gene transcription.

    “It is known that schizophrenia patients have upregulated genes for inflammatory cytokines [122, 123], and downregulated Bdnf gene transcription [124, 125].”

    From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [125]

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Authors
Jin, X., Hu, Z., Kang, Y., Liu, C., Zhou, Y., Wu, X., Liu, J., Zhong, M., Luo, C., Deng, L., Deng, Y., Xie, X., Zhang, Z., Zhou, Y., & Liao, X.
Affiliations
Sichuan University (CN)
Corresponding author
Jin, Xiaodong
ORCID
Venue
Molecular Biology Reports
Publisher
Springer Science and Business Media LLC
Published
2011-10-28
Volume
39
Issue
1
Pages
1-4
ISSN
  • 0301-4851 (ISSN-L)
  • 1573-4978
DOI
10.1007/s11033-010-0377-7
OpenAlex
W2093993520
Cited by
36
References
33
Citations by year
2023: 1 · 2022: 3 · 2020: 2 · 2019: 3 · 2018: 2 · 2016: 3 · 2015: 2 · 2014: 6 · 2013: 9 · 2012: 5
FWCI
5.44
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Molecular Biology Reports (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
IL-10, acute respiratory distress syndrome, 30-day mortality, genetic polymorphism, Chinese population, intensive care unit patients
MeSH terms
Adult, Aged, Female, Genotype, Humans, Male, Middle Aged, Respiratory Distress Syndrome, Polymorphism, Restriction Fragment Length, Odds Ratio, Case-Control Studies, Polymerase Chain Reaction, Interleukin-10, DNA Primers, Asian People, Genetic Association Studies

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