Hyphae-specific genes HGC1, ALS3, HWP1, and ECE1 and relevant signaling pathways in Candida albicans
Abstract
Fungal virulence mechanisms include adhesion to epithelia, morphogenesis, production of secretory hydrolytic enzymes, and phenotype switching, all of which contribute to the process of pathogenesis. A striking feature of the biology of Candida albicans is its ability to grow in yeast, pseudohyphal, and hyphal forms. The hyphal form plays an important role in causing disease, by invading epithelial cells and causing tissue damage. In this review, we illustrate some of the main hyphae-specific genes, namely HGC1, UME6, ALS3, HWP1, and ECE1, and their relevant and reversed signal transduction pathways in reactions stimulated by environmental factors, including pH, CO2, and serum.
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Ume6 is a key regulator of the switch from yeast to hyphal form and of biofilm formation in Candida albicans.
“Because the zinc cluster transcription factor Ume6 is known to be a key regulator of the switch from yeast to hyphal form and of biofilm formation in C. albicans (28–31), we explored its role in C. auris.”
From Ume6-dependent pathways of morphogenesis and biofilm formation in <i>Candida auris</i> (2024) · cites this paper as [30]
Cites
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Ume6-dependent pathways of morphogenesis and biofilm formation in <i>Candida auris</i>
Louvet, M., Li, J., Brandalise, D., Bachmann, D., Sala de Oyanguren, F., Labes, D., Jacquier, N., Genoud, C., Mucciolo, A., Coste, A. T., et al. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.01531-24 · Cited by 20 · see citing works
- Authors
- Fan, Y., He, H., Dong, Y., & Pan, H.
- Affiliations
- Zhejiang University (CN)
- Zhejiang University Medical College Affiliated Stomatological Hospital (CN)
- Corresponding author
- He, Hong
- Pan, Hengbiao
- ORCID
- He, Hong
- Venue
- Mycopathologia
- Published
- 2013-09-04
- Volume
- 176
- Issue
- 5-6
- Pages
- 329-335
- ISSN
- 0301-486X (ISSN-L)
- 1573-0832
- OpenAlex
- W2110020198
- Cited by
- 93
- References
- 5
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 17 · 2023: 5 · 2022: 9 · 2021: 9 · 2020: 7 · 2019: 6 · 2018: 10 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 1
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Mycopathologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- Candida albicans, hyphal growth, Ume6, ALS3, HWP1, endothelin-converting enzyme-1, fungal virulence, morphogenesis, signal transduction, pH sensing, carbon dioxide detection, yeast-to-hypha transition, adhesion, phenotypic switching
- MeSH terms
- Candida albicans, Fungal Proteins, Signal Transduction, Hyphae, Virulence Factors
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