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Cited by 8Pituitary Gland Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsChildhood Cancer Survivors' Quality of Life

Physical function, body mass index, and fitness outcomes in children, adolescents, and emerging adults with craniopharyngioma from proton therapy through five years of follow-up

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Partin, Robyn E., Wogksch, Matthew D., Dhaduk, Rikeenkumar, Ashford, Jason M., Indelicato, Daniel J., Conklin, Heather M., Merchant, Thomas E., Ness, Kirsten K.·2022·Journal of Neuro-Oncology
DOI 10.1007/s11060-022-04116-2PMC PMC9392500
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Abstract

Purpose Children diagnosed with craniopharyngioma are vulnerable to adverse health outcomes. Characterization of body mass index (BMI), physical function, and cardiopulmonary fitness in those treated with proton radiotherapy (PRT) will serve to design interventions to improve outcomes. Methods Ninety-four children with craniopharyngioma completed physical function testing prior to PRT and annually for 5 years. For each outcome, age- and sex-specific z-scores were calculated using normative values. Participants with z-scores > 1.5 or < - 1.5 were classified as impaired. Those with z-scores > 2.0 or < - 2.0 were classified as significantly impaired. Descriptive statistics were used to describe study outcomes and change in prevalence of impairments from 2 to 5 years after treatment. Results Nearly half of participants [45.2%, 95% confidence interval (CI) 39.4, 51.0] had mean BMI z-scores > 1.5 at baseline, with prevalence increasing to 66.7% (95% CI 61.5, 71.9) at 5 years. More than half of participants (54.2%, 95% CI 48.4, 60.0) had knee extension strength z-scores < - 1.5 at baseline, with prevalence increasing to 81.3% (95% CI 77.7, 84.9) at 5 years. BMI and knee extension strength had the largest proportion of participants impaired at both 2 and 5 years (53.2% and 62.3%, respectively). Resting heart rate had the highest proportion of participants not impaired at 2 years but became impaired at 5 years (26.6%). Conclusions Children with craniopharyngioma have BMI and fitness abnormalities at diagnosis and continue 5 years after treatment. This cohort may benefit from interventions designed to improve BMI, strength, and resting indicators of cardiopulmonary fitness.

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  • Individuals with acquired hypothalamic obesity often have low fitness.

    “Individuals with acquired hypothalamic obesity often have both impaired muscle strength and low fitness (38)”

    From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [38]

    The Results (Fitness impairments; page unavailable) report lower-than-expected peak VO₂ and elevated BMI in a cohort of children and young people with craniopharyngioma. The paper does not identify which participants had acquired hypothalamic obesity or show that low fitness was common specifically in that subgroup, so the claim extends beyond the population it assessed. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Individuals with acquired hypothalamic obesity often have impaired muscle strength.

    “Individuals with acquired hypothalamic obesity often have both impaired muscle strength and low fitness (38)”

    From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [38]

    The Discussion reports that over 80% of children with craniopharyngioma had impaired upper- or lower-body muscular strength five years after treatment. It also reports elevated BMI in nearly two-thirds of survivors, but does not identify a subgroup with acquired hypothalamic obesity or establish the frequency of strength impairment in that subgroup. No page number is available in our copy. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Partin, R. E., Wogksch, M. D., Dhaduk, R., Ashford, J. M., Indelicato, D. J., Conklin, H. M., Merchant, T. E., & Ness, K. K.
Affiliations
  • St. Jude Children's Research Hospital (US)
  • University of Florida Health (US)
Corresponding author
Ness, Kirsten K.
ORCID
Venue
Journal of Neuro-Oncology
Publisher
Springer Science and Business Media LLC
Published
2022-08-20
Volume
159
Issue
3
Pages
713-723
ISSN
  • 0167-594X (ISSN-L)
  • 1573-7373
DOI
10.1007/s11060-022-04116-2
PMC
PMC9392500
OpenAlex
W4292461650
Cited by
8
References
0
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 2
FWCI
1.11
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neuro-Oncology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Lebanese Syrian Associated Charities
  • National Institutes of Health (P30CA21765)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
Keywords
craniopharyngioma, proton therapy, physical function, body mass index, cardiorespiratory fitness, quadriceps strength, resting heart rate, long-term follow-up, children, adolescents, emerging adults, treatment side effects
MeSH terms
Adolescent, Child, Craniopharyngioma, Female, Follow-Up Studies, Humans, Male, Pituitary Neoplasms, Protons, Body Mass Index, Proton Therapy

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