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Cited by 18Pituitary Gland Disorders and TreatmentsPhysical Activity and HealthChildhood Cancer Survivors' Quality of Life

Cognitive performance, aerobic fitness, motor proficiency, and brain function among children newly diagnosed with craniopharyngioma

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Conklin, Heather M., Ness, Kirsten K., Ashford, Jason M., Scoggins, Matthew A., Ogg, Robert J., Han, Yuanyuan, Li, Yimei, Bradley, Julie A. +2 more·2019·Journal of the International Neuropsychological Society
DOI 10.1017/s1355617718001170PMC PMC6499492
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Abstract

Objectives:Craniopharyngioma survivors experience cognitive deficits that negatively impact quality of life. Aerobic fitness is associated with cognitive benefits in typically developing children and physical exercise promotes recovery following brain injury. Accordingly, we investigated cognitive and neural correlates of aerobic fitness in a sample of craniopharyngioma patients.Methods:Patients treated for craniopharyngioma [N=104, 10.0±4.6 years, 48% male] participated in fitness, cognitive and fMRI (n=51) assessments following surgery but before proton radiation therapy.Results:Patients demonstrated impaired aerobic fitness [peak oxygen uptake (PKVO 2)=23.9±7.1, 41% impaired (i.e., 1.5 SD<normative mean)], motor proficiency [Bruininks-Oseretsky (BOT2)=38.6±9.0, 28% impaired], and executive functions (e.g., WISC-IV Working Memory Index (WMI)=96.0±15.3, 11% impaired). PKVO 2 correlated with better executive functions (e.g., WISC-IV WMI r=.27,p=.02) and academic performance (WJ-III Calculation r=.24,p=.04). BOT2 correlated with better attention (e.g., CPT-II omissions r=.26,p=.04) and executive functions (e.g., WISC-IV WMI r=.32,p=.01). Areas of robust neural activation during an n-back task included superior parietal lobule, dorsolateral prefrontal cortex, and middle and superior frontal gyri (p<.05, corrected). Higher network activation was associated with better working memory task performance and better BOT2 (p<.001).Conclusions:Before adjuvant therapy, children with craniopharyngioma demonstrate significantly reduced aerobic fitness, motor proficiency, and working memory. Better aerobic fitness and motor proficiency are associated with better attention and executive functions, as well as greater activation of a well-established working memory network. These findings may help explain differential risk/resiliency with respect to acute cognitive changes that may portend cognitive late effects. (JINS, 2019,25, 413–425)

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  • Autonomic impairment may contribute to fatigue, exercise intolerance, and decreased voluntary physical activity in individuals with hypothalamic syndrome.

    “Autonomic impairment may contribute to the fatigue, exercise intolerance, and decreased voluntary physical activity reported by many individuals with hypothalamic syndrome (35, 59, 60).”

    From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [59]

    The Discussion (page unavailable) reports impaired aerobic fitness in children newly diagnosed with craniopharyngioma and suggests tumor effects or surgery could cause physical deconditioning. Our copy does not address whether autonomic impairment contributes to fatigue, exercise intolerance, or reduced voluntary activity in people with hypothalamic syndrome (searched: autonomic impairment, hypothalamic syndrome, and physical activity). (LLM, conf=0.74)

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Authors
Conklin, H. M., Ness, K. K., Ashford, J. M., Scoggins, M. A., Ogg, R. J., Han, Y., Li, Y., Bradley, J. A., Boop, F. A., & Merchant, T. E.
Affiliations
  • St. Jude Children's Research Hospital (US)
  • University of Florida Health (US)
Corresponding author
Conklin, Heather M.
ORCID
Venue
Journal of the International Neuropsychological Society
Publisher
Cambridge University Press (CUP)
Published
2019-04
Volume
25
Issue
04
Pages
413-425
ISSN
  • 1355-6177 (ISSN-L)
  • 1469-7661
DOI
10.1017/s1355617718001170
PMC
PMC6499492
OpenAlex
W2943428978
Cited by
18
References
2
Citations by year
2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 1
FWCI
1.83
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified, 32 d)
Locations
  • Journal of the International Neuropsychological Society (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (P30CA021765)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
Keywords
craniopharyngioma, cardiorespiratory fitness, motor competence, executive function, working memory, attention, brain tumor survivors, children, peak oxygen uptake, n-back task, working memory network, neural correlates of cognition
MeSH terms
Cancer Survivors, Academic Performance, Adolescent, Attention, Brain Injuries, Child, Craniopharyngioma, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Motor Skills, Physical Fitness, Exercise, Executive Function, Cognitive Dysfunction

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