Transcription Factor GATA-3 Regulates the Transcriptional Activity of Dopamine β-Hydroxylase by Interacting with Sp1 and AP4
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GATA-3 is a zinc finger transcription factor that is expressed in T cell lineages as well as in the nervous system during development. In this study, we report that forced expression of GATA-3 resulted in an increased number of dopamine beta-hydroxylase (DBH)-expressing neurons in primary neural crest stem cell (NCSC) culture, suggesting that the DBH gene may be a downstream target gene of GATA-3. GATA-3 robustly transactivates the promoter function of the noradrenaline (NA)-synthesizing DBH gene, via two specific upstream promoter domains; one at -62 to -32 bp and the other at -891 to -853 bp. Surprisingly, none of these domains contain GATA-3 binding sites but encompass binding motifs for transcription factors Sp1 and AP4, respectively. Protein-protein interaction analyses both in vitro and in vivo and chromatin immunoprecipitation (ChIP) assays showed that GATA-3 effects its transcriptional regulatory function through physical interactions with these transcription factors.
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BAZ1B binding regions are enriched for target sites of major regulators of neural crest and its neural derivatives, among which TFAP2A stands out given its core role in neural border formation and neural crest induction and differentiation through binding and stabilization of neural-crest-specific enhancers with NR2F1, NR2F2, and EP300.
“Thus, BAZ1B binding regions are enriched for target sites of major regulators of NC and its neural derivatives (38, 39), among which TFAP2A stands out given its core role in neural border formation and NC induction and differentiation (40) through the binding and stabilization of NC-specific enhancers, in concert with NR2F1, NR2F2, and EP300 (41).”
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Nihei, M., Kawaguchi, S., Mineyama, A., & SATO, T. A. (2023) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b23-00122
- Authors
- Hong, S. J., Choi, H. J., Hong, S., Huh, Y., Chae, H., & Kim, K.-S.
- Affiliations
- Harvard University (US)
- Chonnam National University (KR)
- Corresponding author
- Kim, Kwang-Soo
- Venue
- Neurochemical Research
- Published
- 2008-03-13
- Volume
- 33
- Issue
- 9
- Pages
- 1821-1831
- ISSN
- 0364-3190 (ISSN-L)
- 1573-6903
- PMC
- PMC2712938
- OpenAlex
- W2053441451
- Cited by
- 28
- References
- 45
- Citations by year
- 2023: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 2 · 2013: 1
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neurochemical Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH048866, MH48866, R29MH048866)
- National Institute on Deafness and Other Communication Disorders (DC-006501, R01DC006501)
- National Institute of Neurological Disorders and Stroke (R01NS084869)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- GATA3, dopamine beta-hydroxylase, Sp1, AP-4, transcriptional regulation, neural crest stem cells, noradrenaline synthesis, promoter transactivation, protein-protein interaction, chromatin binding, T cell lineage
- MeSH terms
- Animals, Cells, Cultured, Dopamine beta-Hydroxylase, Gene Expression Regulation, Humans, Neurons, Promoter Regions, Genetic, Quail, Recombinant Fusion Proteins, Transcription Factors, Transcription, Genetic, Sp1 Transcription Factor, GATA3 Transcription Factor
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