Neuroprotective effect of natural products against Alzheimer’s disease
Abstract
Nature has gifted mankind with a plethora of flora-bearing fruits, vegetables and nuts. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease and other neuronal dysfunctions. Accumulated evidence suggests that naturally occurring phyto-compounds, such as polyphenolic antioxidants found in fruits, vegetables, herbs and nuts, may potentially hinder neurodegeneration, and improve memory and cognitive function. Nuts such as walnut have also demonstrated neuroprotective effect against AD. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signalling pathways associated with protein folding and neuroinflammation. The neuroprotective effects of various naturally occurring compounds in AD is evaluating in this review.
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Glycyrrhiza glabra is used in treatment of Alzheimer's disorder because of presence of coumarins, isoflavonoids, saponins, flavonoids, and stilbenoids.
“This plant belongs to the family of Fabaceae and it is used in the treatment of Alzheimer's disorder because of the presence of coumarins, isoflavonoids, saponins, flavonoids, and stilbenoids [52] .”
From Phytotherapy: A promising approach for the treatment of Alzheimer's disease (2022) · cites this paper as [52]
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References 107 · Cited by 278
- Authors
- Essa, M. M., Vijayan, R. K., Castellano-Gonzalez, G., Memon, M. A., Braidy, N., & Guillemin, G. J.
- Affiliations
- Sultan Qaboos University (OM)
- Washington State University (US)
- UNSW Sydney (AU)
- Corresponding author
- Guillemin, Gilles J.
- Venue
- Neurochemical Research
- Published
- 2012-05-22
- Volume
- 37
- Issue
- 9
- Pages
- 1829-1842
- ISSN
- 0364-3190 (ISSN-L)
- 1573-6903
- OpenAlex
- W2065577268
- Cited by
- 278
- References
- 107
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 21 · 2023: 18 · 2022: 22 · 2021: 23 · 2020: 26 · 2019: 20 · 2018: 26 · 2017: 19 · 2016: 17 · 2015: 27 · 2014: 30 · 2013: 12 · 2012: 2
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neurochemical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, neuroprotection, natural products, phytochemicals, antioxidant polyphenols, nuts, Juglans regia, neurodegeneration, neuroinflammation, protein folding, cognitive function, memory
- MeSH terms
- Alzheimer Disease, Animals, Biological Products, Bryozoa, Humans, Plants, Porifera, Seaweed, Neuroprotective Agents, Plant Preparations, Functional Food
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