The DOI matches its Crossref record; 139 of the 139 references it cites were found in a registry or an index.
l-Carnitine and Acetyl-l-carnitine Roles and Neuroprotection in Developing Brain
Open accessAbstract
l-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. Treatment with l-carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism. In recent years there has been considerable interest in the therapeutic potential of l-carnitine and its acetylated derivative acetyl-l-carnitine (ALCAR) for neuroprotection in a number of disorders including hypoxia-ischemia, traumatic brain injury, Alzheimer’s disease and in conditions leading to central or peripheral nervous system injury. There is compelling evidence from preclinical studies that l-carnitine and ALCAR can improve energy status, decrease oxidative stress and prevent subsequent cell death in models of adult, neonatal and pediatric brain injury. ALCAR can provide an acetyl moiety that can be oxidized for energy, used as a precursor for acetylcholine, or incorporated into glutamate, glutamine and GABA, or into lipids for myelination and cell growth. Administration of ALCAR after brain injury in rat pups improved long-term functional outcomes, including memory. Additional studies are needed to better explore the potential of l-carnitine and ALCAR for protection of developing brain as there is an urgent need for therapies that can improve outcome after neonatal and pediatric brain injury.
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Cites
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Neurocognitive outcomes and recovery after pediatric TBI: meta-analytic review of the literature
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Carnitine and Acylcarnitines: Pharmacokinetic, Pharmacological and Clinical Aspects
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Cited by
Oligodendroglial fatty acid metabolism as a central nervous system energy reserve
Asadollahi, E., Trevisiol, A., Saab, A. S., Looser, Z. J., Dibaj, P., Ebrahimi, R., Kusch, K., Ruhwedel, T., Möbius, W., Jahn, O., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01749-6 · Cited by 130
“Unfortunately, that was not possible for mitochondria, because even a triple-KO of all CPT1 genes would not block uptake of short-/medium-chain FAs and lead to the accumulation of neuro-toxic acyl-carnitine 26 .”
BackgroundAcetyl-L-Carnitine in Dementia and Other Cognitive Disorders: A Critical Update
Pennisi, M., Lanza, G., Cantone, M., D’Amico, E., Fisicaro, F., Puglisi, V., Vinciguerra, L., Bella, R., Vicari, E., & Malaguarnera, G. (2020) · Nutrients · doi:10.3390/nu12051389 · Cited by 87
Metadata
- Authors
- Ferreira, G. C., & McKenna, M. C.
- Venue
- Neurochemical Research
- Published
- 2017-05-16
- Volume
- 42
- Issue
- 6
- Pages
- 1661-1675
- ISSN
- 0364-3190 (ISSN-L)
- 1573-6903
- OpenAlex
- W2615540589
- Cited by
- 312
- References
- 139
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- green
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- Ferreira, G. C., & McKenna, M. C. (2017). l-Carnitine and Acetyl-l-carnitine Roles and Neuroprotection in Developing Brain. Neurochemical Research. https://doi.org/10.1007/s11064-017-2288-7
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
