The implications of brain connectivity in the neuropsychology of autism
Open accessAbstract
Autism is a neurodevelopmental disorder that has been associated with atypical brain functioning. Functional connectivity MRI (fcMRI) studies examining neural networks in autism have seen an exponential rise over the last decade. Such investigations have led to the characterization of autism as a distributed neural systems disorder. Studies have found widespread cortical underconnectivity, local overconnectivity, and mixed results suggesting disrupted brain connectivity as a potential neural signature of autism. In this review, we summarize the findings of previous fcMRI studies in autism with a detailed examination of their methodology, in order to better understand its potential and to delineate the pitfalls. We also address how a multimodal neuroimaging approach (incorporating different measures of brain connectivity) may help characterize the complex neurobiology of autism at a global level. Finally, we also address the potential of neuroimaging-based markers in assisting neuropsychological assessment of autism. The quest for a neural marker for autism is still ongoing, yet new findings suggest that aberrant brain connectivity may be a promising candidate.
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Differences in connectivity between distant brain regions in ASD suggest a propensity towards multisensory deficits.
“evidence for differences in connectivity between distant brain regions in children with ASD (Abrams et al., 2013; Assaf et al., 2010; Maximo et al., 2014; Plitt et al., 2015) would also suggest a propensity towards multisensory deficits”
From Behavioral, Perceptual, and Neural Alterations in Sensory and Multisensory Function in Autism Spectrum Disorder (2015) · cites this paper as Maximo et al., 2014
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References 175 · Cited by 259
- Authors
- Maximo, J. O., Cadena, E. J., & Kana, R. K.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Kana, Rajesh K.
- Venue
- Neuropsychology Review
- Published
- 2014-02-05
- Volume
- 24
- Issue
- 1
- Pages
- 16-31
- ISSN
- 1040-7308 (ISSN-L)
- 1573-6660
- PMC
- PMC4059500
- OpenAlex
- W2023044037
- Cited by
- 259
- References
- 175
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 23 · 2023: 23 · 2022: 25 · 2021: 25 · 2020: 12 · 2019: 19 · 2018: 15 · 2017: 30 · 2016: 29 · 2015: 22 · 2014: 11
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychology Review (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000165)
- Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston
- Department of Psychology, University of Alabama at Birmingham
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, brain connectivity, functional connectivity MRI, artificial neural networks, multimodal neuroimaging, neural markers, neuropsychological assessment
- MeSH terms
- Autistic Disorder, Brain, Brain Mapping, Cognition, Humans, Magnetic Resonance Imaging, Neural Pathways, Neuropsychology, Rest
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