The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Mannan-Modified Solid Lipid Nanoparticles for Targeted Gene Delivery to Alveolar Macrophages
Abstract
Purpose Cationic solid lipid nanoparticles (SLN) have established themselves during the past decades. They can efficiently bind DNA directly via ionic interaction and mediate gene transfection. One major problem with SLN is the lack of cell-targeting ability. In the present study, a mannan-based PE-grafted ligand was synthesized and used for the surface modification of DNA-loaded cationic SLN to prepare Man-SLN-DNA.Methods For in vitro test, the cytotoxicity and transfection investigation was carried out on murine macrophage cell line RAW 264.7. For in vivo evaluation, Man-SLN-DNA was delivered into the lung of the rats, and the alveolar macrophages (AM) were isolated for the fluorescence determination of transfection efficiency.Results When compared with non-modified SLN-DNA and Lipofectamine 2000-DNA, Man-SLN-DNA produced the highest gene expressions, especially in vivo.Conclusion These results demonstrated the active targeting ability of this kind of mannan-modified DNA-loaded vehicles, which may have great potential for targeted gene delivery.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Additionally, it is also possible to change the surface chemistry of lipid NPs to achieve active targeting of alveolar macrophages of the lung.”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [214]
In the citing paper
“Mannose is a common ligand associated with lipid NPs.214”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [214]
Citations
Cites
Sica, A., Schioppa, T., Mantovani, A., & Allavena, P. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.01.003 · Cited by 1,483
Jemal, A., Thun, M. J., Ries, L. A. G., Howe, H. L., Weir, H. K., Ward, E., Wu, X., Eheman, C. R., Anderson, R. N., Ajani, U. A., et al. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn389 · Cited by 961
Role of tumor-associated macrophages in tumor progression and invasion
Mantovani, A., Schioppa, T., Porta, C., Allavena, P., & Sica, A. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-9001-7 · Cited by 901
Progress in developing cationic vectors for non-viral systemic gene therapy against cancer
Morille, M., Passirani, C., Vonarbourg, A., Clavreul, A., & Benoît, J. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.036 · Cited by 786
Targeted pharmaceutical nanocarriers for cancer therapy and imaging
Torchilin, V. P. (2007) · The AAPS Journal · doi:10.1208/aapsj0902015 · Cited by 771
Poly(ethylene glycol)-modified Nanocarriers for Tumor-targeted and Intracellular Delivery
van Vlerken, L. E., Vyas, T. K., & Amiji, M. M. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9284-6 · Cited by 646
Uptake of Pneumocystis carinii mediated by the macrophage mannose receptor
Ezekowitz, R. A. B., Williams, D., Koziel, H., Armstrong, M. Y. K., Warner, A., Richards, F. F., & Rose, R. M. (1991) · Nature · doi:10.1038/351155a0 · Cited by 447
Targeted delivery of nanoparticles for the treatment of lung diseases
Azarmi, S., Roa, W. H., & Löbenberg, R. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.11.006 · Cited by 440
Active targeting of brain tumors using nanocarriers
Béduneau, A., Saulnier, P., & Benoît, J. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.06.011 · Cited by 433
Clinical toxicities of nanocarrier systems.
Vega-Villa, K. R., Takemoto, J. K., Yáñez, J. A., Remsberg, C. M., Forrest, M. L., & Davies, N. M. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.11.007 · Cited by 325
Lee, M.-K., Lim, S., & Kim, C. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.01.014 · Cited by 248
Polymer genomics: An insight into pharmacology and toxicology of nanomedicines☆
Kabanov, A. V. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.019 · Cited by 205
Mannose-binding plant lectins: Different structural scaffolds for a common sugar-recognition process
Barre, A., Bourne, Y., Damme, E. J. M. V., Peumans, W. J., & Rougé, P. (2001) · Biochimie · doi:10.1016/s0300-9084(01)01315-3 · Cited by 166
Wijagkanalan, W., Kawakami, S., Takenaga, M., Igarashi, R., Yamashita, F., & Hashida, M. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.10.011 · Cited by 159
Zhao, X. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.01.005 · Cited by 153
Tabatt, K., Sameti, M., Olbrich, C., Müller, R. H., & Lehr, C. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2003.10.015 · Cited by 152
Tseng, C., Wu, S. Y.-H., Wang, W.-H., Peng, C., Lin, F., Lin, C.-C., Young, T., & Shieh, M.-J. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.03.033 · Cited by 150
Nonviral approaches for targeted delivery of plasmid DNA and oligonucleotide
Kawakami, S., Higuchi, Y., & Hashida, M. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21024 · Cited by 140
Biodistribution characteristics of mannosylated, fucosylated, and galactosylated liposomes in mice
Kawakami, S., Wong, J., Sato, A., Hattori, Y., Yamashita, F., & Hashida, M. (2000) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(00)00163-x · Cited by 124
Kaur, A., Jain, S. K., & Tiwary, A. K. (2008) · Acta Pharmaceutica · doi:10.2478/v10007-007-0045-1 · Cited by 116
Topical immunization using nanoengineered genetic vaccines
Cui, Z., & Mumper, R. J. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00051-2 · Cited by 114
Hattori, Y., Kawakami, S., Suzuki, S., Yamashita, F., & Hashida, M. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.03.141 · Cited by 111
Physical Characterization and Macrophage Cell Uptake of Mannan-Coated Nanoparticles
Cui, Z., Hsu, C.-H., & Mumper, R. J. (2003) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-120021318 · Cited by 94
Managit, C., Kawakami, S., Yamashita, F., & Hashida, M. (2005) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20443 · Cited by 93
Yeeprae, W., Kawakami, S., Yamashita, F., & Hashida, M. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.04.010 · Cited by 82
Gene medicines: The end of the beginning?
Rolland, A. P. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.01.002 · Cited by 79
Zou, W., Liu, C., Chen, Z., & Zhang, N. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.11.016 · Cited by 75
Self-citationKarathanasis, E., Chan, L. W., Balusu, S. R., D’Orsi, C. J., Annapragada, A., Sechopoulos, I., & Bellamkonda, R. V. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.08.036 · Cited by 65
Monsigny, M. L. P., Quétard, C., Bourgerie, S., Delay, D., Pichon, C., Midoux, P., Mayer, R., & Roche, A. (1998) · Biochimie · doi:10.1016/s0300-9084(98)80016-3 · Cited by 64
Cui, Z., Han, S., & Huang, L. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000029292.66792.4f · Cited by 54
Novel cationic SLN containing a synthesized single-tailed lipid as a modifier for gene delivery
Yu, W., Liu, C., Ye, J., Zou, W., Zhang, N., & Xu, W. (2009) · Nanotechnology · doi:10.1088/0957-4484/20/21/215102 · Cited by 53
Self-citationSaccharide Modified Pharmaceutical Nanocarriers for Targeted Drug and Gene Delivery
Yu, W., Zhang, N., & Li, C. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209789649547 · Cited by 45
Self-citationMannosylated liposomes for bio-film targeting
Vyas, S. P., Sihorkar, V., & Jain, S. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.08.034 · Cited by 38
Surface Modification of Nanocarriers for Cancer Therapy
Yu, W., & Zhang, N. (2009) · Current Nanoscience · doi:10.2174/157341309788185370 · Cited by 32
Self-citationAnionic solid lipid nanoparticles supported on protamine/DNA complexes
Ye, J., Wang, A., Liu, C., Chen, Z., & Zhang, N. (2008) · Nanotechnology · doi:10.1088/0957-4484/19/28/285708 · Cited by 30
Self-citationMulti-morphological biodegradable PLGE nanoparticles and their drug release behavior
Zhang, H., Bei, J., & Wang, S. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.09.016 · Cited by 22
SHIBATA, K., Kudo, Y., Tsunoda, M., Hosokawa, M., Sakai, Y., Kotani, M., & Aizawa, Y. (2007) · Industrial Health · doi:10.2486/indhealth.45.426 · Cited by 7
Targeted Therapy in Non–Small Cell Lung Cancer: A Commentary
Murer, B. (2008) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2008-132-1573-ttincl · Cited by 6
[Synthesis of N-[2-(cholesteryloxycarbonylamino) ethyl] carbamoylmethylated mannan].
Yang, L., Cheng, L., Wei, Y., & Tian, L. (2003) · PubMed · Cited by 3
Research works printed but not linked: 1
- Wijagkanalan W, Kawakami S, Takenaga M, Igarashi R, Yamashita F, Hashida M. Efficient targeting to alveolar macrophages by intratracheal administration of mannosylated liposomes in rats. J Control Release. 2008;125:121–30. · DOI
Cited by
Sorted by citations
Nanoparticles: a boon to drug delivery, therapeutics, diagnostics and imaging
Parveen, S., Misra, R., & Sahoo, S. K. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.05.016 · Cited by 1,475
Song, M., Liu, T., Shi, C., Zhang, X., & Chen, X. S. (2015) · ACS Nano · doi:10.1021/acsnano.5b06779 · Cited by 665
Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645
Doktorovová, S., Souto, E. B., & Silva, A. M. (2014) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.02.005 · Cited by 419
Geszke-Moritz, M., & Moritz, M. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.05.119 · Cited by 393
Metadata
- Authors
- Yu, W., Liu, C., Liu, Y., Zhang, N., & Xu, W.
- Affiliations
- Shandong University (CN)
- Corresponding author
- Zhang, Na
- Venue
- Pharmaceutical Research
- Published
- 2010-04-27
- Volume
- 27
- Issue
- 8
- Pages
- 1584-1596
- ISSN
- 0724-8741 (ISSN-L)
- 1573-904X
- OpenAlex
- W2008296427
- Cited by
- 137
- References
- 39
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 8 · 2022: 15 · 2021: 9 · 2020: 14 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 7 · 2012: 9
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pharmaceutical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- solid lipid nanoparticles, mannan, cationic liposomes, gene delivery, alveolar macrophages, targeted gene delivery, surface modification, DNA transfection, pulmonary gene delivery, RAW 264.7 macrophages
- MeSH terms
- Animals, Cell Line, Cell Survival, Concanavalin A, Ligands, Lipids, Male, Mannans, Phosphatidylethanolamines, Genetic Therapy, Molecular Structure, Drug Delivery Systems, Macrophages, Alveolar, Rats, Wistar, Cell Line, Tumor, Microscopy, Electron, Transmission, Mice, Rats, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review