Targeted delivery of nanoparticles for the treatment of lung diseases
Abstract
Targeted delivery of drug molecules to organs or special sites is one of the most challenging research areas in pharmaceutical sciences. By developing colloidal delivery systems such as liposomes, micelles and nanoparticles a new frontier was opened for improving drug delivery. Nanoparticles with their special characteristics such as small particle size, large surface area and the capability of changing their surface properties have numerous advantages compared with other delivery systems. Targeted nanoparticle delivery to the lungs is an emerging area of interest. This article reviews research performed over the last decades on the application of nanoparticles administered via different routes of administration for treatment or diagnostic purposes. Nanotoxicological aspects of pulmonary delivery are also discussed.
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Intratracheal administration via suspension nebulization or dry powder inhalation can directly deliver mRNA to the airways of the lungs.
“In contrast to i.v. administration, i.t. administration via suspension nebulization or dry powder inhalation can directly deliver mRNA to the airways of the lungs.[184]”
From RNA delivery biomaterials for the treatment of genetic and rare diseases (2019) · cites this paper as [184]
Using i.t. administration, mRNA can be delivered to alveolar cells, pulmonary endothelium, and immune cells.
“Moreover, using i.t. administration, mRNA can be delivered to a variety of cell types, such as alveolar cells, pulmonary endothelium, and immune cells.[126, 184]”
From RNA delivery biomaterials for the treatment of genetic and rare diseases (2019) · cites this paper as [184]
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- Authors
- Azarmi, S., Roa, W. H., & Löbenberg, R.
- Affiliations
- University of Alberta (CA)
- Corresponding author
- Löbenberg, Raimar
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 60
- Issue
- 8
- Pages
- 863-875
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W1972609612
- Cited by
- 440
- References
- 99
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 22 · 2023: 25 · 2022: 27 · 2021: 25 · 2020: 24 · 2019: 23 · 2018: 18 · 2017: 21 · 2016: 27 · 2015: 28 · 2014: 35 · 2013: 25 · 2012: 33
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- targeted drug delivery, nanoparticles, lung disease, pulmonary drug delivery, liposomes, micelles, colloidal drug delivery systems, route of administration, nanotoxicology
- MeSH terms
- Animals, Antibodies, Monoclonal, Humans, Lung, Lung Diseases, Magnetics, Drug Delivery Systems, Gene Transfer Techniques, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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