Cited by 440Inhalation and Respiratory Drug DeliveryNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

Targeted delivery of nanoparticles for the treatment of lung diseases

Azarmi, Shirzad, Roa, Wilson H., Löbenberg, Raimar·2008·Advanced Drug Delivery Reviews

Abstract

Targeted delivery of drug molecules to organs or special sites is one of the most challenging research areas in pharmaceutical sciences. By developing colloidal delivery systems such as liposomes, micelles and nanoparticles a new frontier was opened for improving drug delivery. Nanoparticles with their special characteristics such as small particle size, large surface area and the capability of changing their surface properties have numerous advantages compared with other delivery systems. Targeted nanoparticle delivery to the lungs is an emerging area of interest. This article reviews research performed over the last decades on the application of nanoparticles administered via different routes of administration for treatment or diagnostic purposes. Nanotoxicological aspects of pulmonary delivery are also discussed.

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Registry

Crossref · 10.1016/j.addr.2007.11.006

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95 of 95 references verified0 citation errors · 0 not checkable

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  • Intratracheal administration via suspension nebulization or dry powder inhalation can directly deliver mRNA to the airways of the lungs.

    “In contrast to i.v. administration, i.t. administration via suspension nebulization or dry powder inhalation can directly deliver mRNA to the airways of the lungs.[184]”
  • Using i.t. administration, mRNA can be delivered to alveolar cells, pulmonary endothelium, and immune cells.

    “Moreover, using i.t. administration, mRNA can be delivered to a variety of cell types, such as alveolar cells, pulmonary endothelium, and immune cells.[126, 184]”

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Authors
Azarmi, S., Roa, W. H., & Löbenberg, R.
Affiliations
University of Alberta (CA)
Corresponding author
Löbenberg, Raimar
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2008-05
Volume
60
Issue
8
Pages
863-875
ISSN
0169-409X (ISSN-L)
OpenAlex
W1972609612
Cited by
440
References
99
Citations by year
2026: 11 · 2025: 12 · 2024: 22 · 2023: 25 · 2022: 27 · 2021: 25 · 2020: 24 · 2019: 23 · 2018: 18 · 2017: 21 · 2016: 27 · 2015: 28 · 2014: 35 · 2013: 25 · 2012: 33
FWCI
4.33
Type
journal article
Language
en
Open access
closed
Locations
  • Advanced Drug Delivery Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
targeted drug delivery, nanoparticles, lung disease, pulmonary drug delivery, liposomes, micelles, colloidal drug delivery systems, route of administration, nanotoxicology
MeSH terms
Animals, Antibodies, Monoclonal, Humans, Lung, Lung Diseases, Magnetics, Drug Delivery Systems, Gene Transfer Techniques, Nanoparticles

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