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A Uniform Ultra-Small Microsphere/SAIB Hybrid Depot with Low Burst Release for Long-Term Continuous Drug Release
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“Xia Lin’s study and our previous study showed that the combination of microsphere and SAIB could significantly decrease burst release of the investigated drugs”
From Electrosprayed minocycline hydrochloride-loaded microsphere/SAIB hybrid depot for periodontitis treatment (2021) · cites this paper as Lin et al., 2015
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“which could be related to the increase in the amount of dissolved drug in SAIB from the microsphere surface (Lin et al., 2015).”
From Electrosprayed minocycline hydrochloride-loaded microsphere/SAIB hybrid depot for periodontitis treatment (2021) · cites this paper as Lin et al., 2015
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Research works printed but not linked: 41
- Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM. Polymeric systems for controlled drug release. Chem Rev. 1999;99(11):3181–98. · DOI · Paper page
- Heres S, Lambert M, Vauth R. Treatment of early episode in patients with schizophrenia: the role of long acting antipsychotics. Eur Psychiatry. 2014;29 Suppl 2(14):1409–13. · DOI
- Hoybye C, Christiansen JS. Growth hormone replacement in adults—current standards and new perspectives. Best Pract Res Clin Endocrinol Metab. 2015;29(1):115–23. · DOI
- Jiang Y, Wang F, Xu H, Liu H, Meng Q, Liu W. Development of andrographolide loaded PLGA microspheres: optimization, characterization and in vitro-in vivo correlation. Int J Pharm. 2014;475(1–2):475–84. · DOI
- Doan TV, Couet W, Olivier JC. Formulation and in vitro characterization of inhalable rifampicin-loaded PLGA microspheres for sustained lung delivery. Int J Pharm. 2011;414(1–2):112–7. · DOI
- Hu Z, Liu Y, Yuan W, Wu F, Su J, Jin T. Effect of bases with different solubility on the release behavior of risperidone loaded PLGA microspheres. Colloids Surf B: Biointerfaces. 2011;86(1):206–11. · doi:10.1016/j.colsurfb.2011.03.043
- Shive MS, Anderson JM. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Deliv Rev. 1997;28(1):5–24. · DOI · Paper page
- Schwendeman SP, Shah RB, Bailey BA, Schwendeman AS. Injectable controlled release depots for large molecules. J Control Release. 2014;190:240–53. · DOI · Paper page
- Wischke C, Schwendeman SP. Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles. Int J Pharm. 2008;364(2):298–327. · DOI · Paper page
- Wang J, Wang BA, Schwendeman SP. Characterization of the initial burst release of a model peptide from poly(D, L-lactide-co-glycolide) microspheres. J Control Release. 2002;82(2–3):289–307. · DOI · Paper page
- Yang J, Wilson M, Celniker A. Recombinant human growth hormone poly(lactic-co-glycolic acid) (PLGA) microspheres provide a long lasting effect. J Control Release. 1997;49(97):193–205(13).
- Ereshefsky L, Mannaert E. Pharmacokinetic profile and clinical efficacy of long-acting risperidone: potential benefits of combining an atypical antipsychotic and a new delivery system. Drugs R&D. 2005;6(3):129–37. · DOI
- Eerdekens M, Van Hove I, Remmerie B, Mannaert E. Pharmacokinetics and tolerability of long-acting risperidone in schizophrenia. Schizophr Res. 2004;70(1):91–100. · DOI · Paper page
- Sun F, Sui C, Teng L, Liu X, Teng L, Meng Q, et al. Studies on the preparation, characterization and pharmacological evaluation of tolterodine PLGA microspheres. Int J Pharm. 2010;397(1–2):44–9. · doi:10.1016/j.ijpharm.2010.06.042
- Luan X, Bodmeier R. Modification of the tri-phasic drug release pattern of leuprolide acetate-loaded poly(lactide-co-glycolide) microparticles. Eur J Pharm Biopharm. 2006;63(2):205–14. · DOI
- Su Z, Sun F, Shi Y, Jiang C, Meng Q, Teng L, et al. Effects of formulation parameters on encapsulation efficiency and release behavior of risperidone poly(D, L-lactide-co-glycolide) microsphere. Chem Pharm Bull (Tokyo). 2009;57(11):1251–6. · DOI
- Husmann M, Schenderlein S, Luck M, Lindner H, Kleinebudde P. Polymer erosion in PLGA microparticles produced by phase separation method. Int J Pharm. 2002;242(1–2):277–80. · DOI
- Berkland C, King M, Cox A, Kim K, Pack DW. Precise control of PLG microsphere size provides enhanced control of drug release rate. J Control Release. 2002;82(1):137–47. · DOI · Paper page
- Berkland C, Kim K, Pack DW. PLG microsphere size controls drug release rate through several competing factors. Pharm Res. 2003;20(7):1055–62. · DOI · Paper page
- Gao Z, Ding P, Zhang L, Shi J, Yuan S, Wei J, et al. Study of a pingyangmycin delivery system: Zein/Zein-SAIB in situ gels. Int J Pharm. 2007;328(1):57–64. · doi:10.1016/j.ijpharm.2006.07.048
- Kraeling RR, Barb CR, Rampacek GB, Thompson Jr DL, Gibson JW, Sullivan SA, et al. Luteinizing hormone response to controlled-release deslorelin in estradiol benzoate primed ovariectomized gilts. Theriogenology. 2000;53(9):1681–9. · doi:10.1016/s0093-691x(00)00307-1
- Shi X, Lin X, Yao C, Shen L, Feng Y. Injectable long-acting in situ forming systems for Radix Ophiopogonis polysaccharide. Int J Biol Macromol. 2015;72:553–9. · DOI
- Okumu FW, Dao LN, Fielder PJ, Dybdal N, Brooks D, Sane S, et al. Sustained delivery of human growth hormone from a novel gel system: SABER. Biomaterials. 2002;23(22):4353–8. · DOI
- Pechenov S, Shenoy B, Yang MX, Basu SK, Margolin AL. Injectable controlled release formulations incorporating protein crystals. J Control Release : Off J Control Release Soc. 2004;96(1):149–58. · DOI
- Lin X, Yang S, Gou J, Zhao M, Zhang Y, Qi N, et al. A novel risperidone-loaded SAIB-PLGA mixture matrix depot with a reduced burst release: effects of solvents and PLGA on drug release behaviors in vitro/in vivo. J Mater Sci Mater Med. 2012;23(2):443–55. · DOI
- Lu Y, Tang X, Cui Y, Zhang Y, Qin F, Lu X. In vivo evaluation of risperidone-SAIB in situ system as a sustained release delivery system in rats. Eur J Pharm Biopharm. 2008;68(2):422–9. · DOI
- Huang X, Brazel CS. On the importance and mechanisms of burst release in matrix-controlled drug delivery systems. J Control Release. 2001;73(2–3):121–36. · DOI · Paper page
- Lu YX, Yu YL, Tang X. Sucrose acetate isobutyrate as an in situ forming system for sustained risperidone release. J Pharm Sci. 2007;96(12):3252–62. · DOI
- Qi F, Wu J, Yang T, Ma G, Su Z. Mechanistic studies for monodisperse exenatide-loaded PLGA microspheres prepared by different methods based on SPG membrane emulsification. Acta Biomater. 2014;10(10):4247–56. · DOI
- Qi F, Wu J, Fan QZ, He F, Tian GF, Yang TY, et al. Preparation of uniform-sized exenatide-loaded PLGA microspheres as long-effective release system with high encapsulation efficiency and bio-stability. Colloids Surf B: Biointerfaces. 2013;112(3):492–8. · DOI
- Piacentini E, Drioli E, Giorno L. Membrane emulsification technology: twenty-five years of inventions and research through patent survey. J Membr Sci. 2014;468(20):410–22. · doi:10.1016/j.memsci.2014.05.059
- Thomas C, Gupta V, Ahsan F. Particle size influences the immune response produced by hepatitis B vaccine formulated in inhalable particles. Pharm Res. 2010;27(5):905–19. · DOI
- Tran VT, Benoit JP, Venier-Julienne MC. Why and how to prepare biodegradable, monodispersed, polymeric microparticles in the field of pharmacy? Int J Pharm. 2011;407(1–2):1–11. · DOI · Paper page
- Procter BG, Chappel CI. Subchronic toxicity studies of sucrose acetate isobutyrate (SAIB) in the rat and dog. Food Chem Toxicol. 1998;36(2):101–10. · doi:10.1016/s0278-6915(97)80301-8
- Reynolds RC. Metabolism and pharmacokinetics of sucrose acetate isobutyrate (SAIB) and sucrose octaisobutyrate (SOIB) in rats, dogs, monkeys or humans: a review. Food Chem Toxicol. 1998;36(2):95–9. · doi:10.1016/s0278-6915(97)00123-3
- Reynolds RC, Chappel CI. Sucrose acetate isobutyrate (SAIB): historical aspects of its use in beverages and a review of toxicity studies prior to 1988. Food Chem Toxicol. 1998;36(2):81–93. · doi:10.1016/s0278-6915(97)80300-6
- Phillips JC, Kingsnorth J, Rowland I, Gangolli SD, Lloyd AG. Studies on the metabolism of sucrose acetate isobutyrate in the rat and in man. Food Cosmet Toxicol. 1976;14(5):375–80. · doi:10.1016/s0015-6264(76)80172-1
- Gogolewski S, Jovanovic M, Perren SM, Dillon JG, Hughes MK. Tissue response and in vivo degradation of selected polyhydroxyacids: polylactides (PLA), poly(3-hydroxybutyrate) (PHB), and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHB/VA). J Biomed Mater Res. 1993;27(9):1135–48. · DOI · Paper page
- Huffman K, Casey D. Effect of carboxyl end groups on hydrolysis of polyglycolic acid. J Polym Sci Polym Chem Ed. 1985;23(7):1939–54. · DOI
- Kazazi-Hyseni F, Zandstra J, Popa ER, Goldschmeding R, Lathuile AA, Veldhuis GJ, et al. Biocompatibility of poly(d, l-lactic-co-hydroxymethyl glycolic acid) microspheres after subcutaneous and subcapsular renal injection. Int J Pharm. 2015;482(1–2):99–109. · DOI
- Pajander J, Soikkeli AM, Korhonen O, Forbes RT, Ketolainen J. Drug release phenomena within a hydrophobic starch acetate matrix: FTIR mapping of tablets after in vitro dissolution testing. J Pharm Sci. 2008;97(8):3367–78. · doi:10.1002/jps.21236
Cited by
Zhang, T., Qiu, Y., Song, J., Zhou, P., Liao, H., Cheng, Y., & Wu, X. (2021) · Drug Delivery · doi:10.1080/10717544.2021.1902020 · Cited by 36
Metadata
- Authors
- Lin, X., Xu, Y., Tang, X., Zhang, Y., Chen, J., Zhang, Y., He, H., & Yang, Z.
- Venue
- Pharmaceutical Research
- Published
- 2015-06-16
- Volume
- 32
- Issue
- 11
- Pages
- 3708-3721
- ISSN
- 0724-8741
- 1573-904X
- Cited by
- 18
- References
- 0
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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- CoChat. (2026). Citation check: A Uniform Ultra-Small Microsphere/SAIB Hybrid Depot with Low Burst Release for Long-Term Continuous Drug Release. https://app.cochat.ai/papers/10.1007/s11095-015-1731-1
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- Lin, X., Xu, Y., Tang, X., Zhang, Y., Chen, J., Zhang, Y., He, H., & Yang, Z. (2015). A Uniform Ultra-Small Microsphere/SAIB Hybrid Depot with Low Burst Release for Long-Term Continuous Drug Release. Pharmaceutical Research. https://doi.org/10.1007/s11095-015-1731-1
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