The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.
A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes
Open accessAbstract
Diabetes mellitus is a multifactorial global health disorder that is rising at an alarming rate. Cardiovascular diseases, kidney damage and neuropathy are the main cause of high mortality rates among individuals with diabetes. One effective therapeutic approach for controlling hyperglycemia associated with type-2 diabetes is to target alpha-amylase and alpha-glucosidase, enzymes that catalyzes starch hydrolysis in the intestine. At present, approved inhibitors for these enzymes are restricted to acarbose, miglitol and voglibose. Although these inhibitors retard glucose absorption, undesirable gastrointestinal side effects impede their application. Therefore, research efforts continue to seek novel inhibitors with improved efficacy and minimal side effects. Natural products of plant origin have been a valuable source of therapeutic agents with lesser toxicity and side effects. The anti-diabetic potential through alpha-glucosidase inhibition of plant-derived molecules are summarized in this review. Eight molecules (Taxumariene F, Akebonoic acid, Morusin, Rhaponticin, Procyanidin A2, Alaternin, Mulberrofuran K and Psoralidin) were selected as promising drug candidates and their pharmacokinetic properties and toxicity were discussed where available.
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1 retracted
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The carbohydrate-active enzymes database (CAZy) in 2013
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Association between insulin resistance and the development of cardiovascular disease
Ormazabal, V., Nair, S., Elfeky, O., Aguayo, C., Salomon, C., & Zuñiga, F. A. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0762-4 · Cited by 2,280
Phytochemicals: extraction, isolation, and identification of bioactive compounds from plant extracts
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Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe)
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Risk Factors Contributing to Type 2 Diabetes and Recent Advances in the Treatment and Prevention
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Cited by
Mamadalieva, N. Z., Hussain, H., Mollica, A., Zengin, G., Mamadalieva, R. Z., Elhady, S. S., Fadil, S. A., Ashour, M. L., & Youssef, F. S. (2022) · Life · doi:10.3390/life12060824 · Cited by 7
Metadata
- Authors
- Dirir, A. M., Daou, M., Yousef, A. F., & Yousef, L. F.
- Venue
- Phytochemistry Reviews
- Published
- 2021-08-16
- Volume
- 21
- Issue
- 4
- Pages
- 1049-1079
- ISSN
- 1568-7767 (ISSN-L)
- 1572-980X
- OpenAlex
- W3193722096
- Cited by
- 586
- References
- 142
- FWCI
- 44.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dirir, A. M., Daou, M., Yousef, A. F., & Yousef, L. F. (2022). A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes. Phytochemistry Reviews. https://doi.org/10.1007/s11101-021-09773-1
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
