Cited by 148Plant nutrient uptake and metabolismGenetically Modified Organisms ResearchCrop Yield and Soil Fertility

The DOI matches its Crossref record; 21 of the 24 references it cites were found in a registry or an index.

High Lysine and High Tryptophan Transgenic Maize Resulting from the Reduction of Both 19- and 22-kD α-zeins

Huang, Shihshieh, Frizzi, Alessandra, Florida, Cheryl A., Kruger, Diane E., Luethy, Michael H.·2006·Plant Molecular Biology

DOI 10.1007/s11103-006-0027-6

Open this paper in CoChat — free account

Abstract

The major maize seed storage proteins, zeins, are deficient in lysine and tryptophan content, which contribute to the poor nutritional quality of corn. Whether through the identification of mutations or genetic engineering, kernels with reduced levels of zein proteins have been shown to have increased levels of lysine and tryptophan. It has been hypothesized that these increases are due to the reduction of lysine-poor zeins and a pleiotropic increase in the lysine-rich non-zein proteins. By transforming maize with constructs expressing chimeric double-stranded RNA, kernels derived from stable transgenic plants displayed significant declines in the accumulation of both 19- and 22-kD alpha-zeins, which resulted in higher lysine and tryptophan content than previously reported for kernels with reduced zein levels. The observation that lysine and tryptophan content is correlated with the protein levels measured in transgenic maize kernels is consistent with the hypothesis that a pleiotropic increase in non-zein proteins is contributing to an improved amino acid balance. In addition, a large increase in accumulation of free amino acids, consisting predominantly of asparagine, aspartate and glutamate, was observed in the zein reduction kernels.

Integrity signals

Registry

Crossref · 10.1007/s11103-006-0027-6

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Construct design for efficient, effective and high‐throughput gene silencing in plants
Wesley, S. V., Helliwell, C. A., Smith, N. A., Wang, M., Rouse, D. T., Liu, Q., Gooding, P. S., Singh, S. P., Abbott, D., Stoutjesdijk, P. A., et al. (2001) · The Plant Journal · doi:10.1046/j.1365-313x.2001.01105.x · Cited by 1,542
Mutant Gene That Changes Protein Composition and Increases Lysine Content of Maize Endosperm
Mertz, E. T., Bates, L. S., & Nelson, O. E. (1964) · Science · doi:10.1126/science.145.3629.279 · Cited by 1,102
Branched-Chain Amino Acid Metabolism
Harper, A. E., Miller, R. H., & Block, K. P. (1984) · Annual Review of Nutrition · doi:10.1146/annurev.nu.04.070184.002205 · Cited by 1,011
Branched-Chain Amino Acid Metabolism
Yudkoff, M. (1999) · Cited by 762
Second Mutant Gene Affecting the Amino Acid Pattern of Maize Endosperm Proteins
Nelson, O. E., Mertz, E. T., & Bates, L. S. (1965) · Science · doi:10.1126/science.150.3702.1469 · Cited by 338
RNAi-mediated replacement of morphine with the nonnarcotic alkaloid reticuline in opium poppy
Allen, R. S., Millgate, A. G., Chitty, J. A., Thisleton, J., MILLER, J. A., Fist, A. J., Gerlach, W. L., & Larkin, P. J. (2004) · Nature Biotechnology · doi:10.1038/nbt1033 · Cited by 294
Genomics Analysis of Genes Expressed in Maize Endosperm Identifies Novel Seed Proteins and Clarifies Patterns of Zein Gene Expression
Woo, Y., Hu, D. W.-N., Larkins, B. A., & Jung, R. (2001) · The Plant Cell · doi:10.1105/tpc.010240 · Cited by 280
A New Opaque Variant of Maize by a Single Dominant RNA-Interference-Inducing Transgene
Segal, G., Song, R., & Messing, J. W. (2003) · Genetics · doi:10.1093/genetics/165.1.387 · Cited by 227
High-throughput vectors for efficient gene silencing in plants
Helliwell, C. A., Wesley, S. V., Wielopolska, A., & Waterhouse, P. M. (2002) · Functional Plant Biology · doi:10.1071/fp02033 · Cited by 171
The Prolamins of Maize
Coleman, C. E., & Larkins, B. A. (1999) · Springer eBooks · doi:10.1007/978-94-011-4431-5_6 · Cited by 133

Show all 24 references

Research works printed but not linked: 4

E. Dembinski, 1995, Acta Physiol. Plant, 17, 361
D.J. Dyer, 1997, Feedstuffs, 69, 16
B.M. Prasanna, 2001, Curr. Sci., 81, 1308
J.L. Puckett, 1991, Maydica, 36, 161

Sorted by citations

Biofortified Crops Generated by Breeding, Agronomy, and Transgenic Approaches Are Improving Lives of Millions of People around the World
Garg, M., Sharma, N., Sharma, S., Kapoor, P., Kumar, A., Chunduri, V., & Arora, P. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00012 · Cited by 742
Improving the protein content and composition of cereal grain
Shewry, P. R. (2007) · Journal of Cereal Science · doi:10.1016/j.jcs.2007.06.006 · Cited by 504
Fortifying plants with the essential amino acids lysine and methionine to improve nutritional quality
Galili, G., & Amir, R. (2012) · Plant Biotechnology Journal · doi:10.1111/pbi.12025 · Cited by 286
Improving the Content of Essential Amino Acids in Crop Plants: Goals and Opportunities
Ufaz, S., & Galili, G. (2008) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.118091 · Cited by 268
Reducing Rice Seed Storage Protein Accumulation Leads to Changes in Nutrient Quality and Storage Organelle Formation
Kawakatsu, T., Hirose, S., Yasuda, H., & Takaiwa, F. (2010) · PLANT PHYSIOLOGY · doi:10.1104/pp.110.164343 · Cited by 204
Breeding and disseminating quality protein maize (QPM) for Africa
Krivanek, A. F., Groote, H. D., Gunaratna, N. S., & Diallo, A. (2007) · doi:10.5897/ajb2007.000-2007 · Cited by 181
Elevating optimal human nutrition to a central goal of plant breeding and production of plant-based foods
Sands, D. C., Morris, C. E., Dratz, E. A., & Pilgeram, A. L. (2009) · Plant Science · doi:10.1016/j.plantsci.2009.07.011 · Cited by 158
Prevalence and impacts of genetically engineered feedstuffs on livestock populations1
Van Eenennaam, A. L., & Young, A. E. (2014) · Journal of Animal Science · doi:10.2527/jas.2014-8124 · Cited by 154
High‐lysine corn generated by endosperm‐specific suppression of lysine catabolism using RNAi
Houmard, N. M., Mainville, J. L., Bonin, C. P., Huang, S., Luethy, M. H., & Malvar, T. M. (2007) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2007.00265.x · Cited by 149
Breeding Quality Protein Maize (QPM): Protocols for Developing QPM CultivarsPreprint
Vivek, B., Krivanek, A. F., Palacios‐Rojas, N., Afriyie, S. T., & Diallo, A. (2008) · RePEc: Research Papers in Economics · doi:10.22004/ag.econ.56179 · Cited by 138
Proteome balancing of the maize seed for higher nutritional value
Wu, Y., & Messing, J. W. (2014) · Frontiers in Plant Science · doi:10.3389/fpls.2014.00240 · Cited by 136
Tapping RNA silencing pathways for plant biotechnology
Frizzi, A., & Huang, S. (2010) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2010.00505.x · Cited by 133
Modifying lysine biosynthesis and catabolism in corn with a single bifunctional expression/silencing transgene cassette
Frizzi, A., Huang, S., Gilbertson, L. A., Armstrong, T. A., Luethy, M. H., & Malvar, T. M. (2007) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2007.00290.x · Cited by 123
Recent advances in the study of prolamin storage protein organization and function
Holding, D. R. (2014) · Frontiers in Plant Science · doi:10.3389/fpls.2014.00276 · Cited by 112
Impact of Genetics and Environment on Nutritional and Metabolite Components of Maize Grain
Harrigan, G. G., Stork, L. G., Riordan, S. G., Reynolds, T. L., Ridley, W. P., Masucci, J. D., MacIsaac, S., Halls, S. C., Orth, R. G., Smith, R. G., et al. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf070494k · Cited by 104
Identification and characterization of lysine-rich proteins and starch biosynthesis genes in the opaque2mutant by transcriptional and proteomic analysis
Jia, M., Wu, H., Clay, K. L., Jung, R., Larkins, B. A., & Gibbon, B. C. (2013) · BMC Plant Biology · doi:10.1186/1471-2229-13-60 · Cited by 99
Relationship between asparagine metabolism and protein concentration in soybean seed
Pandurangan, S., Pająk, A., Molnar, S. J., Cober, E. R., Dhaubhadel, S., Hernández‐Sebastià, C., Kaiser, W. M., Nelson, R. L., Huber, S. C., & Marsolais, F. (2012) · Journal of Experimental Botany · doi:10.1093/jxb/ers039 · Cited by 90
Omics Technologies to Enhance Plant Based Functional Foods: An Overview
Nayak, S. N., Aravind, B., Malavalli, S. S., Sukanth, B. S., Poornima, R., Bharati, P., Hefferon, K. L., Kole, C., & Puppala, N. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.742095 · Cited by 83
Improving Nutritional Quality of Plant Proteins Through Genetic Engineering
Le, D. T., Chu, H. D., & Lea, N. Q. (2016) · Current Genomics · doi:10.2174/1389202917666160202215934 · Cited by 83
Reliable and Inexpensive Colorimetric Method for Determining Protein-Bound Tryptophan in Maize Kernels
Nurit, E., Tiessen, A., Pixley, K. V., & Palacios‐Rojas, N. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf901315x · Cited by 82
Modulation of kernel storage proteins in grain sorghum (Sorghum bicolor (L.) Moench)
Kumar, T., Dweikat, I., Sato, S. J., Ge, Z., Nersesian, N., Chen, H., Elthon, T., Bean, S. R., Ioerger, B. P., Tilley, M., et al. (2012) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2012.00685.x · Cited by 81
Quality protein maize (QPM): Importance, genetics, timeline of different events, breeding strategies and varietal adoption
Maqbool, M. A., Issa, A. B., & Khokhar, E. S. (2021) · Plant Breeding · doi:10.1111/pbr.12923 · Cited by 76
Quality Protein Maize: Progress and Prospects
Atlin, G. N., Palacios‐Rojas, N., Babu, R., Das, B., Twumasi‐Afriyie, S., Friesen, D. K., Groote, H. D., Vivek, B., & Pixley, K. V. (2010) · Plant breeding reviews · doi:10.1002/9780470880579.ch3 · Cited by 74
CRISPR/Cas9 editing of three CRUCIFERIN C homoeologues alters the seed protein profile in Camelina sativa
Lyzenga, W. J., Harrington, M., Bekkaoui, D. R., Wigness, M., Hegedus, D. D., & Rozwadowski, K. L. (2019) · BMC Plant Biology · doi:10.1186/s12870-019-1873-0 · Cited by 74
Nonredundant Function of Zeins and Their Correct Stoichiometric Ratio Drive Protein Body Formation in Maize Endosperm
Guo, X., Yuan, L., Chen, H., Sato, S. J., Clemente, T. E., & Holding, D. R. (2013) · PLANT PHYSIOLOGY · doi:10.1104/pp.113.218941 · Cited by 72
Characterisation of the tryptophan synthase alpha subunit in maize
Kriechbaumer, V., Weigang, L. M. M., Fießelmann, A., Letzel, T., Frey, M., Gierl, A., & Glawischnig, E. (2008) · BMC Plant Biology · doi:10.1186/1471-2229-8-44 · Cited by 70
Balancing of sulfur storage in maize seed
Wu, Y., Wang, W., & Messing, J. W. (2012) · BMC Plant Biology · doi:10.1186/1471-2229-12-77 · Cited by 68
High-lysine maize: the key discoveries that have made it possible
Azevedo, R. A., & Arruda, P. (2010) · Amino Acids · doi:10.1007/s00726-010-0576-5 · Cited by 67
Review article: Quality protein maize (QPM): Genetic manipulation for the nutritional fortification of maize
Sofi, P. A., Wani, S. A., Rather, A. G., & Wani, S. H. (2009) · Journal of Plant Breeding and Crop Science · doi:10.5897/jpbcs.9000113 · Cited by 67
Biofortification as a solution for addressing nutrient deficiencies and malnutrition
Naik, B., Kumar, V., Rizwanuddin, S., Mishra, S., Kumar, V., Saris, P. E. J., Khanduri, N., Kumar, A., Pandey, P., Gupta, A. K., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30595 · Cited by 69
Grain characteristics and composition of maize specialty hybrids
Žilić, S., Milašinović‐Šeremešić, M., Terzić, D., Barać, M., & Ignjatović‐Micić, D. (2011) · Spanish Journal of Agricultural Research · doi:10.5424/sjar/20110901-053-10 · Cited by 62
Advances in Maize Genomics and Their Value for Enhancing Genetic Gains from Breeding
Xu, Y., Skinner, D. J., Wu, H., Palacios‐Rojas, N., Araus, J. L., Yan, J., Gao, S., Warburton, M. L., & Crouch, J. H. (2009) · International Journal of Plant Genomics · doi:10.1155/2009/957602 · Cited by 61
Gene silencing using the recessive rice bacterial blight resistance gene xa13 as a new paradigm in plant breeding
Li, C., Wei, J., Lin, Y., & Chen, H. (2012) · Plant Cell Reports · doi:10.1007/s00299-011-1206-8 · Cited by 58
High-value products from transgenic maize
Naqvi, S., Ramessar, K., Farré, G., Sabalza, M., Miralpeix, B., Twyman, R. M., Capell, T., Zhu, C., & Christou, P. (2010) · Biotechnology Advances · doi:10.1016/j.biotechadv.2010.08.009 · Cited by 57
Metabolite Analyses of Grain from Maize Hybrids Grown in the United States under Drought and Watered Conditions during the 2002 Field Season
Harrigan, G. G., Stork, L. G., Riordan, S. G., Ridley, W. P., MacIsaac, S., Halls, S. C., Orth, R. G., Rau, D., Smith, R. G., Wen, L., et al. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf070493s · Cited by 53
Control limits for accumulation of plant metabolites: brute force is no substitute for understanding
Morandini, P. A. (2013) · Plant Biotechnology Journal · doi:10.1111/pbi.12035 · Cited by 52
Kernel amino acid composition and protein content of introgression lines from Zea mays ssp. mexicana into cultivated maize
Wang, L., Xu, C., Qu, M., & Zhang, J. (2007) · Journal of Cereal Science · doi:10.1016/j.jcs.2007.09.014 · Cited by 50
Mutational Breeding and Genetic Engineering in the Development of High Grain Protein Content
Wenefrida, I., Utomo, H. S., & Linscombe, S. D. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf4016812 · Cited by 49
Lysine biofortification of crops to promote sustained human health in the 21st century
Yang, Q., Zhao, D., Zhang, C., Sreenivasulu, N., Sun, S. S. M., & Liu, Q. (2021) · Journal of Experimental Botany · doi:10.1093/jxb/erab482 · Cited by 46
Genetic manipulation of lysine catabolism in maize kernels
Reyes, A. R., Bonin, C. P., Houmard, N. M., Huang, S., & Malvar, T. M. (2008) · Plant Molecular Biology · doi:10.1007/s11103-008-9409-2 · Cited by 43
Preparation and characterization of extruded thermoplastic zein–poly(propylene carbonate) film
Chen, Y., Ye, R., Xiu-ming, L., & Wang, J. (2013) · Industrial Crops and Products · doi:10.1016/j.indcrop.2013.04.040 · Cited by 41
Double zero tillage and foliar phosphorus fertilization coupled with microbial inoculants enhance maize productivity and quality in a maize–wheat rotation
Harish, M. N., Choudhary, A. K., Kumar, S., Dass, A., Singh, V. K., Sharma, V., Varatharajan, T., Dhillon, M. K., Sangwan, S., Dua, V., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-07148-w · Cited by 41
Compositional and transcriptional analyses of reduced zein kernels derived from the opaque2 mutation and RNAi suppression
Frizzi, A., Caldo, R. A., Morrell, J. A., Wang, M., Lutfiyya, L. L., Brown, W. E., Malvar, T. M., & Huang, S. (2010) · Plant Molecular Biology · doi:10.1007/s11103-010-9644-1 · Cited by 41
Transgenic sorghum with improved digestibility of storage proteins obtained by Agrobacterium-mediated transformation
Elkonin, L. A., Italianskaya, J. V., Domanina, I. V., Selivanov, N. Y., Rakitin, A. L., & Ravin, N. V. (2016) · Russian Journal of Plant Physiology · doi:10.1134/s1021443716050046 · Cited by 39
Improved Nutritive Quality and Salt Resistance in Transgenic Maize by Simultaneously Overexpression of a Natural Lysine-Rich Protein Gene, SBgLR, and an ERF Transcription Factor Gene, TSRF1
Wang, M., Liu, C., Shixue, L., Zhu, D., Zhao, Q., & Yu, J. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14059459 · Cited by 39
Manipulation of amino acid composition in soybean seeds by the combination of deregulated tryptophan biosynthesis and storage protein deficiency
Kita, Y., Nakamoto, Y., Takahashi, M., Kitamura, K., Wakasa, K., & Ishimoto, ‍. (2009) · Plant Cell Reports · doi:10.1007/s00299-009-0800-5 · Cited by 37
Rice proteins and essential amino acids
Kawakatsu, T., & Takaiwa, F. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811508-4.00004-6 · Cited by 33
Combining P and Zn fertilization to enhance yield and grain quality in maize grown on Mediterranean soils
Sánchez‐Rodríguez, A. R., Rey, M.-D., Nechate-Drif, H., Castillejo, M. Á., Jorrín-Novo, J. V., Torrent, J., del Campillo, M. C., & Sacristán, D. (2021) · Scientific Reports · doi:10.1038/s41598-021-86766-2 · Cited by 32
Molecular Breeding for Quality Protein Maize (QPM)
Babu, R., & Prasanna, B. M. (2013) · Springer eBooks · doi:10.1007/978-94-007-7575-6_21 · Cited by 32
Induced protein polymorphisms and nutritional quality of gamma irradiation mutants of sorghum
Mehlo, L., Mbambo, Z., Bado, S., Lin, J., Moagi, S. M., Buthelezi, S. G., Stoychev, S., & Chikwamba, R. K. (2013) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2013.05.002 · Cited by 31
Novel Genetic Selection System for Quantitative Trait Loci of Quality Protein Maize
Wu, Y., & Messing, J. W. (2011) · Genetics · doi:10.1534/genetics.111.131078 · Cited by 31
Morphology and Properties of a New Biodegradable Material Prepared from Zein and Poly(butylene adipate-terephthalate) by Reactive Blending
Wei, B., Zhao, Y., Wei, Y., Yao, J., Chen, X., & Shao, Z. (2019) · ACS Omega · doi:10.1021/acsomega.9b00210 · Cited by 31
Biofortification Under Climate Change: The Fight Between Quality and Quantity
Maqbool, A., Abrar, M. M., Bakhsh, A., Çalışkan, S., Khan, H. Z., Aslam, M., & Aksoy, E. (2020) · Springer eBooks · doi:10.1007/978-3-030-49732-3_9 · Cited by 30
Dynamic Gene Copy Number Variation in Collinear Regions of Grass Genomes
Xu, J., Bennetzen, J. L., & Messing, J. W. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr261 · Cited by 28
Microbial-assisted and genomic-assisted breeding: a two way approach for the improvement of nutritional quality traits in agricultural crops
Chandra, A. K., Kumar, A., Bharati, A., Joshi, R., Agrawal, A., & Kumar, S. (2019) · 3 Biotech · doi:10.1007/s13205-019-1994-z · Cited by 29
Increasing the production yield of recombinant protein in transgenic seeds by expanding the deposition space within the intracellular compartment
Takaiwa, F. (2013) · Bioengineered · doi:10.4161/bioe.24187 · Cited by 27
Seed-Specific Expression of a Lysine-Rich Protein Gene, GhLRP, from Cotton Significantly Increases the Lysine Content in Maize Seeds
Jing, Y., Li, C., Zhao, Q., Zhu, D., & Yu, J. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15045350 · Cited by 25
Electrophoretic and chromatographic evaluation of transgenic barley expressing a bacterial dihydrodipicolinate synthase
Ohnoutková, L., Zítka, O., Mrízová, K., Vasková, J., Galuszka, P., Cernei, N., Smedley, M. A., Harwood, W., Adam, V., & Kizek, R. (2012) · Electrophoresis · doi:10.1002/elps.201200033 · Cited by 24
Lysine metabolism in antisense C-hordein barley grains
Schmidt, D., Rizzi, V., Gaziola, S. A., Médici, L. O., Vincze, É., Kozak, M., Lea, P. J., & Azevedo, R. A. (2014) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2014.12.017 · Cited by 23
Editing the 19 kDa alpha‐zein gene family generates non‐ opaque2 ‐based quality protein maize
Hurst, P., Sato, S. J., Ferris, T. W., Yobi, A., Zhou, Y., Angelovici, R., Clemente, T. E., & Holding, D. R. (2023) · Plant Biotechnology Journal · doi:10.1111/pbi.14237 · Cited by 22
Genetically Modified Plants for Nutritionally Improved Food: A Promise Kept?
Lombardo, L., & Grando, S. (2019) · Food Reviews International · doi:10.1080/87559129.2019.1613664 · Cited by 22
Nutritional Quality of Sorghum Seeds: Storage Proteins and Amino Acids
Vendemiatti, A., Ferreira, R. R., Gomes, L. H., Médici, L. O., & Azevedo, R. A. (2008) · Food Biotechnology · doi:10.1080/08905430802463487 · Cited by 22
The Problem with Nutritionally Enhanced Plants
Schubert, D. R. (2008) · Journal of Medicinal Food · doi:10.1089/jmf.2008.0094 · Cited by 22
Relevance of genetically modified crops in light of future environmental and legislative challenges to the agri‐environment
O’Brien, M., & Mullins, E. D. (2008) · Annals of Applied Biology · doi:10.1111/j.1744-7348.2008.00304.x · Cited by 20
Genetic Engineering of Maize (Zea mays L.) with Improved Grain Nutrients
Guo, X., Duan, X., Wu, Y., Cheng, J., Zhang, J., Zhang, H., & Li, B. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b05390 · Cited by 20
Enhancement of Amino Acid Availability in Corn Grain
Alan, L. K. (2008) · Biotechnology in agriculture and forestry · doi:10.1007/978-3-540-68922-5_7 · Cited by 19
Genetic engineering to improve essential and conditionally essential amino acids in maize: transporter engineering as a reference
Hasan, M. M., & Rima, R. (2021) · Transgenic Research · doi:10.1007/s11248-021-00235-0 · Cited by 18
Specialty Corns
Scott, P., Pratt, R. C., Hoffman, N., & Montgomery, R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811971-6.00010-3 · Cited by 22
A Brief History of Promoter Development for Use in Transgenic Maize Applications
Nuccio, M. L. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7315-6_4 · Cited by 17
Physical traits and nutritional quality of selected Serbian maize genotypes differing in kernel hardness and colour
Milašinović‐Šeremešić, M., Radosavljević, M., Srdić, J., Tomičić, Z., & Ðuragić, O. (2019) · Food and Feed Research · doi:10.5937/ffr1901051m · Cited by 16
Utilizing the underutilized plant resources for development of life style foods: Putting nutrigenomics to use
Mir, R. A., Nazir, M., Sabreena, Naik, S., Mukhtar, S., Ganai, B. A., & Zargar, S. M. (2022) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2021.12.038 · Cited by 15
Temporal profiling of essential amino acids in developing maize kernel of normal, opaque-2 and QPM germplasm
Sethi, M., Kumar, S., Singh, A., & Chaudhary, D. P. (2019) · Physiology and Molecular Biology of Plants · doi:10.1007/s12298-019-00724-x · Cited by 15
Biofortified Maize – A Genetic Avenue for Nutritional Security
Babu, R., Palacios‐Rojas, N., & Prasanna, B. (2013) · doi:10.1002/9781118728482.ch10 · Cited by 15
An update on the maize zein-gene family in the post-genomics era
Khan, N. U., Sheteiwy, M. S. A., Lihua, N., Khan, M. M. U., & Zhao, H. Q. (2019) · Food Production Processing and Nutrition · doi:10.1186/s43014-019-0012-5 · Cited by 14
Quality Protein Maize Based on Reducing Sulfur in Leaf Cells
Planta, J. R. G., & Messing, J. W. (2017) · Genetics · doi:10.1534/genetics.117.300288 · Cited by 13
Influence of genotype and texture on zein content in endosperm of maize grains
Landry, J., & Delhaye, S. (2007) · Annals of Applied Biology · doi:10.1111/j.1744-7348.2007.00173.x · Cited by 13
Molecular Improvement of Grain: Target Traits for a Changing World
Singer, S. D., Foroud, N. A., & Laurie, J. D. (2018) · Elsevier eBooks · doi:10.1016/b978-0-08-100596-5.22439-6 · Cited by 13
Genetic modification of sorghum for improved nutritional value: state of the problem and current approaches
Elkonin, L. A. (2018) · Journal of Investigative Genomics · doi:10.15406/jig.2018.05.00076 · Cited by 12
Exploitation of Heterosis in Single Cross Hybrids of Quality Protein Maize (Zea maize L.) for Yield and Quality Traits
Bisen, P., Dadheech, A., Namrata, N., Nagar, O. P., & Meena, R. K. (2017) · International Journal of Bio-resource and Stress Management · doi:10.23910/ijbsm/2017.8.1.1748 · Cited by 12
Characterization of free amino acid QTLs in maize opaque2 recombinant inbred lines
Pineda‐Hidalgo, K. V., Lavin-Aramburo, M., Salazar-Salas, N. Y., Chávez‐Ontiveros, J., Reyes‐Moreno, C., Muy‐Rangel, M. D., Larkins, B. A., & López‐Valenzuela, J. A. (2011) · Journal of Cereal Science · doi:10.1016/j.jcs.2011.01.005 · Cited by 12
Prospects of chloroplast metabolic engineering for developing nutrient-dense food crops
Tanwar, N., Arya, S. S., Rookes, J. E., Cahill, D. M., Lenka, S. K., & Bansal, K. C. (2022) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2022.2092717 · Cited by 11
RNAi-Mutants of Sorghum bicolor (L.) Moench with Improved Digestibility of Seed Storage Proteins
Elkonin, L. A., Panin, V. M., Kenzhegulov, O. A., & Sarsenova, S. K. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.96204 · Cited by 10
Use of RNA Interference Technology for Improving Economically Valuable Traits of Cereal Crops
Дубровна, О. В., Mykhalska, S. I., & Комисаренко, А. Г. (2023) · Cytology and Genetics · doi:10.3103/s0095452723060026 · Cited by 9
Towards programming-based synthetic genetic circuit enabled high-lysine maize
Hasan, M. M. (2024) · Current Plant Biology · doi:10.1016/j.cpb.2024.100355 · Cited by 9
Production of transgenic cattle expressing lysine-rich polypeptide in milk by somatic cell nuclear transfer
Zhang, S., Ma, X., Wang, Z., Zhang, P., & Li, Z. (2019) · Transgenic Research · doi:10.1007/s11248-019-00124-7 · Cited by 9
Transformation of LRP gene into Brassica napus mediated by agrobacterium tumefaciens to enhance lysine content in seeds
Wang, J., Chen, L., Liu, Q. Q., Sun, S. S. M., Соколов, В. А., & Wang, Y. (2011) · Russian Journal of Genetics · doi:10.1134/s1022795411120167 · Cited by 9
Structural and transcriptional analysis of plant genes encoding the bifunctional lysine ketoglutarate reductase saccharopine dehydrogenase enzyme
Anderson, O. D., Coleman‐Derr, D., Gu, Y., & Heath, S. (2010) · BMC Plant Biology · doi:10.1186/1471-2229-10-113 · Cited by 8
Current Challenges in Plant Genetics, Genomics, Bioinformatics, and Biotechnology
(2019) · doi:10.18699/icg-plantgen2019-82 · Cited by 8
General Aspects of Genetic Improvement (Traditional and Transgenic Methods) Aiming to Food Biofortification
Hina, A., Abbasi, A., Imtiaz, S., Haq, I. U., Hassan, A. U., & Chaudhry, A. (2023) · Springer eBooks · doi:10.1007/978-3-031-33957-8_4 · Cited by 7
Nutrigenomics in Cereals
Yadav, S. K., Yadav, P. D., & Chinnusamy, V. (2023) · Springer eBooks · doi:10.1007/978-981-19-4308-9_12 · Cited by 7
Optical and Structural Properties of Zein‐Xanthan Gum Biofilms
de Almeida, C. B., & Filho, J. F. L. (2011) · Macromolecular Symposia · doi:10.1002/masy.200900082 · Cited by 7
Current Status of Application and Commercialization of Genetically Modified Plants for Human and Livestock Health and Phytoremediation
Yoshimatsu, K., Kawano, N., Kawahara, N., Akiyama, H., Teshima, R., & Nishijima, M. (2012) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.132.629 · Cited by 7
Fortification of Ogi with Whey Increases Essential Amino Acids Content of Fortified Product
Omole, J. O., Ighodaro, O. M., & Durosinolorun, O. (2017) · International Scholarly Research Notices · doi:10.1155/2017/7450845 · Cited by 7
Improving Nutrient Value of Crops: Applications of RNAi in Targeting Plant Metabolic Pathways
Chakrabarti, S., Chatterjee, C., & Mandal, A. (2021) · Concepts and strategies in plant sciences · doi:10.1007/978-3-030-64994-4_10 · Cited by 6
GENETIC ENGINEERING AS A TOOL FOR MODIFICATION OF SEED STORAGE PROTEINS AND IMPROVEMENT OF NUTRITIONAL VALUE OF CEREAL GRAIN (review)
Elkonin, L. A., Domanina, I. V., & Ital’yanskaya, Y. V. (2016) · Sel skokhozyaistvennaya Biologiya · doi:10.15389/agrobiology.2016.1.17eng · Cited by 6
Biomass Crops for Biofuels and Bio-based Products
Hood, E. E., Teoh, K., Devaiah, S. P., & Requesens, D. V. (2012) · Springer eBooks · doi:10.1007/978-1-4419-0851-3_170 · Cited by 6
Lysine Matters: Genetic and Biotechnological Innovations to Combat Protein Malnutrition
Singh, V., Mishra, M., Singla-Pareek, S. L., Roy, J. K., & Pareek, A. (2025) · Plant Cell & Environment · doi:10.1111/pce.70316 · Cited by 5
Improving the nutritional quality of cereals by conventional and novel approaches
Shewry, P. R. (2008) · Elsevier eBooks · doi:10.1533/9781845693886.2.159 · Cited by 5
Dissecting the genetic architecture of polygenic nutritional traits in maize through meta-QTL analysis
Kumar, B., Yankanchi, S., Singh, R., Pushpendra, P., Sarkar, D., Kumar, P., Kumar, K., Choudhary, M., Jat, B. S., & Jat, H. S. (2025) · Food Chemistry Molecular Sciences · doi:10.1016/j.fochms.2025.100256 · Cited by 5
Maize Productivity in the New Millennium
Ali, A. A. (2021) · Springer water · doi:10.1007/978-3-030-64323-2_19 · Cited by 5

Authors: Huang, S., Frizzi, A., Florida, C. A., Kruger, D. E., & Luethy, M. H.
Affiliations: Monsanto (United States) (US)
Corresponding author: Huang, Shihshieh
Venue: Plant Molecular Biology
Publisher: Springer Science and Business Media LLC
Published: 2006-06
Volume: 61
Issue: 3
Pages: 525-535
ISSN: 0167-4412 (ISSN-L)
1573-5028
DOI: 10.1007/s11103-006-0027-6
OpenAlex: W1999124505
Cited by: 148
References: 24
Citations by year: 2026: 6 · 2025: 8 · 2024: 3 · 2023: 10 · 2022: 4 · 2021: 9 · 2020: 2 · 2019: 12 · 2018: 7 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 13 · 2012: 10
FWCI: 11.46
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Plant Molecular Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant nutrient uptake and metabolism
Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Crop Yield and Soil Fertility
Keywords: transgenic maize, alpha-zein, lysine, tryptophan, seed storage proteins, amino acid composition, free amino acids, asparagine, aspartic acid, glutamate
MeSH terms: Amino Acids, Zea mays, Genetic Engineering, Genetic Vectors, Lysine, RNA, Double-Stranded, Seeds, Transformation, Genetic, Tryptophan, Zein, Blotting, Northern, Gene Silencing, Plants, Genetically Modified

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

High Lysine and High Tryptophan Transgenic Maize Resulting from the Reduction of Both 19- and 22-kD α-zeins

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks