Cited by 154Genetically Modified Organisms ResearchAgricultural safety and regulationsAnimal Genetics and Reproduction

Prevalence and impacts of genetically engineered feedstuffs on livestock populations1

Van Eenennaam, A. L., Young, A. E.·2014·Journal of Animal Science

Abstract

Globally, food-producing animals consume 70 to 90% of genetically engineered (GE) crop biomass. This review briefly summarizes the scientific literature on performance and health of animals consuming feed containing GE ingredients and composition of products derived from them. It also discusses the field experience of feeding GE feed sources to commercial livestock populations and summarizes the suppliers of GE and non-GE animal feed in global trade. Numerous experimental studies have consistently revealed that the performance and health of GE-fed animals are comparable with those fed isogenic non-GE crop lines. United States animal agriculture produces over 9 billion food-producing animals annually, and more than 95% of these animals consume feed containing GE ingredients. Data on livestock productivity and health were collated from publicly available sources from 1983, before the introduction of GE crops in 1996, and subsequently through 2011, a period with high levels of predominately GE animal feed. These field data sets, representing over 100 billion animals following the introduction of GE crops, did not reveal unfavorable or perturbed trends in livestock health and productivity. No study has revealed any differences in the nutritional profile of animal products derived from GE-fed animals. Because DNA and protein are normal components of the diet that are digested, there are no detectable or reliably quantifiable traces of GE components in milk, meat, and eggs following consumption of GE feed. Globally, countries that are cultivating GE corn and soy are the major livestock feed exporters. Asynchronous regulatory approvals (i.e., cultivation approvals of GE varieties in exporting countries occurring before food and feed approvals in importing countries) have resulted in trade disruptions. This is likely to be increasingly problematic in the future as there are a large number of "second generation" GE crops with altered output traits for improved livestock feed in the developmental and regulatory pipelines. Additionally, advanced techniques to affect targeted genome modifications are emerging, and it is not clear whether these will be encompassed by the current GE process-based trigger for regulatory oversight. There is a pressing need for international harmonization of both regulatory frameworks for GE crops and governance of advanced breeding techniques to prevent widespread disruptions in international trade of livestock feedstuffs in the future.

AI snapshot

Written from the paper’s full text.

TL;DR

This review concludes that GE feedstuffs are compositionally equivalent to conventional feed and that livestock performance, health, and animal-product composition are comparable between GE-fed and non-GE-fed animals, based on feeding studies and field data from over 100 billion U.S. animals (2000–2011). It also warns that asynchronous regulatory approvals and zero-tolerance policies are causing trade disruptions and will become more problematic with second-generation GE crops and gene editing.

Key findings

  • Experimental feeding studies consistently show performance and health of GE-fed animals comparable to those fed near-isogenic non-GE lines; no study has revealed differences in the nutritional profile of milk, meat, or eggs, and neither recombinant DNA nor intact recombinant protein has been detected in animal products.
  • U.S. field data from 1983–2011, including over 100 billion animals after GE crop introduction, showed no unfavorable or perturbed trends in livestock health and productivity; available health indicators improved over time (e.g., dairy somatic cell count fell from 304,000 cells/mL in 1995 to 217,000 in 2011; broiler feed-to-gain fell from 2 in 1985 to 1.91 in 2011; cattle and poultry condemnation/mortality rates decreased).
  • GE feed dominates global trade: an estimated 92.75–95.9% of traded soybeans, 64–92.7% of traded corn, 69% of cotton, and 84.2–85% of canola may contain GE material; non-GE-fed animal products are a niche market (<5% of U.S. animals), with organic livestock shares such as 0.33% of broilers, 1.97% of layers, 0.20% of turkeys, 0.34% of beef cows, 2.78% of dairy cows, and 0.01% of hogs in 2011.
  • Asynchronous approvals caused trade disruptions, including China’s rejection of U.S. corn: 3.3 million t were subject to rejection and diverted shipments (1.4 million t) or canceled/deferred sales, with estimated losses up to $2.9 billion; GE crops added an estimated 122 and 230 million t to global soybean and corn production, reduced pesticide spraying by 499 million kg (−8.7%), and lowered environmental impact by 18.1%.

Methods

  • Design: narrative review of peer-reviewed livestock GE feeding studies and animal-product composition studies, plus analysis of publicly available U.S. livestock productivity and health data from 1983 through 2011, comparing pre-GE (1983–1994) and high-GE-feed (2000–2011) periods.
  • Data: broiler, dairy, hog, and beef industries; sources included USDA Economics, Statistics, and Market Information System, USDA National Agricultural Statistics Service, USDA FSIS, National Chicken Council, and published audits; global production/trade data came from USDA Foreign Agricultural Service, FAO, Brookes and Barfoot, and others.
  • Analysis: regression analyses were performed for 1983–1994 and 2000–2011, and slopes between periods were compared using an unpaired t test where data were available; feeding-study and trade data were summarized descriptively.

Limitations

  • Paper-stated: whole-food animal feeding trials have low power to detect adverse effects, are limited by how much GE feed can be included without nutritional imbalance, and contribute little to safety assessment once compositional equivalence is established; fewer than 100 long-term (>90 d) and multigenerational target-animal GE feeding studies exist in the peer-reviewed literature.
  • Paper-stated: long-term and multigenerational studies should be reserved for cases where reasonable doubt remains after a 90-d feeding trial triggered by a potential hazard, and statistically significant differences in such studies are not necessarily adverse effects.
  • Evident from the text: the field analysis is observational, relies on aggregated publicly available data and regression slope comparisons, and cannot establish causality or individual-level exposure; the review is described as brief/narrative rather than a systematic review or meta-analysis.

Model-written summary. Check it against the paper before relying on it.

Integrity signals

Registry

Crossref · 10.2527/jas.2014-8124

Cites

107 of 107 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Claims the paper makes

0 of 137 cited sources checked · 0 supported · 0 flagged

  • Findingnone given
    § Prevalence and impacts of genetically engineered feedstuffs on livestock populations 1 · p. 1

    More than 95% of United States food-producing animals consume feed containing GE ingredients.

    “and more than 95% of these animals consume feed containing GE ingredients.”
    Quote in the paperSubstantial claim
  • Findingown data
    § Prevalence and impacts of genetically engineered feedstuffs on livestock populations 1 · p. 1

    Field data sets representing over 100 billion animals following the introduction of GE crops did not reveal unfavorable or perturbed trends in livestock health and productivity.

    “These field data sets, representing over 100 billion animals following the introduction of GE crops, did not reveal unfavorable or perturbed trends in livestock health and productivity.”
    Quote in the paperSubstantial claim
  • Findingnone given
    § 2013 Data on Global Production and Trade in Genetically Engineered Feedstuffs and Sources of Non-Genetically Engineered Feedstuffs · p. 11

    79% (85 million ha) of global soybean hectarage is planted to GE varieties.

    “It is estimated that 79% (85 million ha) of global soybean hectarage is planted to GE varieties (Fig. 3).”
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    § Livestock Feeding Studies with Genetically Engineered Feed · p. 5

    During 2011, less than 5% of United States animals within each of the major livestock sectors were raised for certified National Organic Program markets that specifically prohibit the feeding of GE feed.

    “During 2011, less than 5% of U.S. animals within each of the major livestock sectors were raised for certified National Organic Program ( NOP ) markets that specifically prohibit the feeding of GE feed (Table 2).”
    Quote in the paperNot a substantial claim
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    § 2013 Data on Global Production and Trade in Genetically Engineered Feedstuffs and Sources of Non-Genetically Engineered Feedstuffs · p. 11

    32% (57 million ha) of global corn hectarage is planted with GE varieties.

    “Although only 32% (57 million ha) of global corn hectarage is planted with GE varieties (Fig. 3), 71% of global trade came from those countries that grow GE corn varieties (Fig. 6).”
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    § Prevalence and impacts of genetically engineered feedstuffs on livestock populations 1 · p. 1

    United States animal agriculture produces over 9 billion food-producing animals annually.

    “United States animal agriculture produces over 9 billion foodproducing animals annually”
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    § Field Datasets of Livestock Populations Fed with Genetically Engineered Feed · p. 7

    An estimated 24 consecutive generations of broilers would have been consuming GE feed during the time period 2000 to 2011.

    “An estimated 24 consecutive generations of broilers would have been consuming GE feed during the time period 2000 to 2011.”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: In a typical U.S. broiler operation, chickens are fed for 42–49 d on diets composed of approximately 35% soybean meal and 65% corn grain.
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    § Field Datasets of Livestock Populations Fed with Genetically Engineered Feed · p. 8

    There was no indication of worsening animal health after the introduction of GE feed, and productivity improvements continued in the same direction and at similar rates as those observed before the introduction of GE crop varieties in 1996.

    “There was no indication of worsening animal health after the introduction of GE feed, and productivity improvements continued in the same direction and at similar rates as those that were observed before the introduction of GE crop varieties in 1996.”
    Quote in the paperSubstantial claim
    • Rests on an assumption: All animals arriving at USDA-inspected slaughter facilities undergo both antemortem and postmortem inspections to identify abnormalities.
    • Rests on an assumption: Carcasses are condemned postmortem if there are visible lesions or tumors present on organs and carcasses.
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    § Field Datasets of Livestock Populations Fed with Genetically Engineered Feed · p. 7

    Broiler mortality was essentially unchanged throughout the years presented and was also at its lowest in 2011.

    “Moreover, mortality was essentially unchanged throughout the years presented and was also at its lowest in 2011.”
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    Findingcitation
    § 2013 Data on Global Production and Trade in Genetically Engineered Feedstuffs and Sources of Non-Genetically Engineered Feedstuffs · p. 11

    The EU imports 65% of its protein-rich feedstuffs, for which there are no alternative sources grown in the EU.

    “The EU imports 65% of its protein-rich feedstuffs, for which there are no alternative sources grown in the EU (Popp et al., 2013), and is the largest importer of soybean meal and the second largest importer of soybeans after China (Fig. 4 and 5).”
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    § 2013 Data on Global Production and Trade in Genetically Engineered Feedstuffs and Sources of Non-Genetically Engineered Feedstuffs · p. 11

    Poultry are the single largest domestic user of soybean meal, consuming about half of all meal, followed by swine.

    “Poultry continue to be the single largest domestic user of soybean meal, consuming about half of all meal, followed by swine.”
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    § Field Datasets of Livestock Populations Fed with Genetically Engineered Feed · p. 7

    Cattle fed or finished in feedyards made up the majority (82%) of the cattle at harvest but represented a minority (12%) of the cattle condemned.

    “Cattle fed or finished in feedyards, typically for 120 d before slaughter on high concentrate diets containing corn and soy as major ingredients, made up the majority (82%) of the cattle at harvest but represented a minority (12%) of the cattle condemned.”
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    • cites White and Moore, 2009

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    • Rests on an assumption: All animals arriving at USDA-inspected slaughter facilities undergo both antemortem and postmortem inspections to identify abnormalities.
    • Rests on an assumption: Carcasses are condemned postmortem if there are visible lesions or tumors present on organs and carcasses.
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    Findingnone given
    § Field Datasets of Livestock Populations Fed with Genetically Engineered Feed · p. 7

    The rate of broiler carcass condemnation decreased significantly over time and was at its lowest in 2011.

    “The rate of broiler carcass condemnation decreased significantly over time and was at its lowest in 2011.”
    Quote in the paperSubstantial claim
    • Rests on an assumption: All animals arriving at USDA-inspected slaughter facilities undergo both antemortem and postmortem inspections to identify abnormalities.
    • Rests on an assumption: Carcasses are condemned postmortem if there are visible lesions or tumors present on organs and carcasses.
  • May combine two claims.

    Findingown data
    § 2013 Data on Global Production and Trade in Genetically Engineered Feedstuffs and Sources of Non-Genetically Engineered Feedstuffs · p. 11

    The EU is the largest importer of soybean meal and the second largest importer of soybeans after China.

    “The EU imports 65% of its protein-rich feedstuffs, for which there are no alternative sources grown in the EU (Popp et al., 2013), and is the largest importer of soybean meal and the second largest importer of soybeans after China (Fig. 4 and 5).”
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    • cites Fig. 4 and 5

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    Findingcitation
    § 2013 Data on Global Production and Trade in Genetically Engineered Feedstuffs and Sources of Non-Genetically Engineered Feedstuffs · p. 11

    Approximately 85% of soybean and 57% of corn grain production are used in global livestock diets annually.

    “It is estimated that approximately 85% of soybean and 57% of corn grain production (USDA Foreign Agricultural Service, 2014b) are used in global livestock diets annually.”
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    • cites USDA Foreign Agricultural Service, 2014b

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    § Field Datasets of Livestock Populations Fed with Genetically Engineered Feed · p. 7

    Condemnation rates for non-fed cattle, particularly cows, were higher than for fed cattle, but the rate in 2007 (2.49%) was similar to that reported in cattle in 1994 (2.6%) before the introduction of GE crops.

    “Condemnation rates for non-fed cattle, particularly cows, were higher than for fed cattle, but the rate in 2007 (2.49%), the last year for which data are available, was similar to that reported in cattle in 1994 (2.6%; Boleman et al., 1998), before the introduction of GE crops.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Boleman et al., 1998 source

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    • Rests on an assumption: All animals arriving at USDA-inspected slaughter facilities undergo both antemortem and postmortem inspections to identify abnormalities.
    • Rests on an assumption: Carcasses are condemned postmortem if there are visible lesions or tumors present on organs and carcasses.
  • Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based). May combine two claims.

    Findingnone given
    § Livestock Feeding Studies with Genetically Engineered Feed · p. 5

    United States agriculture feeds billions of food-producing animals each year, with annual broiler numbers alone exceeding the current size of the global human population.

    “United States agriculture feeds billions of food-producing animals each year, with annual broiler numbers alone exceeding the current size of the global human population (Table 2).”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingnone given
    § 2013 Data on Global Production and Trade in Genetically Engineered Feedstuffs and Sources of Non-Genetically Engineered Feedstuffs · p. 11

    About 70% of soybean meal consumed in the EU is imported and 80% of this meal is produced from GE soybeans.

    “About 70% of soybean meal consumed in the EU is imported and 80% of this meal is produced from GE soybeans.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingown data
    § Field Datasets of Livestock Populations Fed with Genetically Engineered Feed · p. 7

    The available health parameters-somatic cell count in dairy, postmortem condemnation rates in cattle, and postmortem condemnation rates and mortality in poultry-all decreased (improved) over time.

    “The available health parameters, somatic cell count (an indicator of mastitis and inflammation in the udder) in the dairy data set (Fig. 1), postmortem condemnation rates in cattle (Fig. 1), and postmortem condemnation rates and mortality in the poultry industry (Fig. 2) all decreased (i.e., improved) over time.”
    Quote in the paperSubstantial claim
    • Rests on an assumption: All animals arriving at USDA-inspected slaughter facilities undergo both antemortem and postmortem inspections to identify abnormalities.
    • Rests on an assumption: Carcasses are condemned postmortem if there are visible lesions or tumors present on organs and carcasses.
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingnone given
    § 2013 Data on Global Production and Trade in Genetically Engineered Feedstuffs and Sources of Non-Genetically Engineered Feedstuffs · p. 11

    In the 2011 to 2012 marketing year, domestic animal agriculture used 27.6 million t of U.S. soybean meal.

    “In the 2011 to 2012 marketing year, domestic animal agriculture used 27.6 million t of U.S. soybean meal.”
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  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Findingcitation
    § 2013 Data on Global Production and Trade in Genetically Engineered Feedstuffs and Sources of Non-Genetically Engineered Feedstuffs · p. 11

    In Asia, consumption of meat and dairy products has been increasing annually by approximately 3 and 5%, respectively.

    “In Asia alone, consumption of meat and dairy products has been increasing annually by approximately 3 and 5%, respectively (Food and Agriculture Organization of the United Nations, 2012).”
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    • cites Food and Agriculture Organization of the United Nations, 2012

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    § Current U.S. Options for Products from Non-Genetically Engineered Fed Livestock · p. 15

    In 2011, the United States had 1.26 million ha of certified organic cropland and 0.93 million ha of certified organic pasture and range.

    “In 2011, the United States had 1.26 million ha of certified organic cropland and 0.93 million ha of certified organic pasture and range (USDA National Agricultural Statistics Service, 2012).”
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    • cites USDA National Agricultural Statistics Service, 2012

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    § Current U.S. Options for Products from Non-Genetically Engineered Fed Livestock · p. 15

    This translates into roughly 0.8 and 0.5% of total U.S. cropland and pasture/rangeland, respectively.

    “This translates into roughly 0.8 and 0.5% of total U.S. cropland and pasture/rangeland, respectively (Fig. 7).”
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    § Current U.S. Options for Products from Non-Genetically Engineered Fed Livestock · p. 15

    The amount of organic farmland increased well over 1,000% in these countries between 2002 and 2006, while organic farmland in Europe and North America showed slower (27-80%) expansion rates.

    “The amount of organic farmland increased well over 1,000% in these countries between 2002 and 2006, while organic farmland in Europe and North America showed slower (27-80%) expansion rates (Grow and Greene, 2009).”
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    • cites Grow and Greene, 2009

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    § Current U.S. Options for Products from Non-Genetically Engineered Fed Livestock · p. 15

    In 2009, Canada was the main market for U.S. organic exports, while countries in Latin America, including Mexico, Brazil, Argentina, and Uruguay, along with China and other countries in Asia are major sources of organic imports.

    “In 2009, Canada was the main market for U.S. organic exports, while countries in Latin America, including Mexico, Brazil, Argentina, and Uruguay, along with China and other countries in Asia are major sources of organic imports (Grow and Greene, 2009).”
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    • cites Grow and Greene, 2009

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    § 2013 Data on Global Production and Trade in Genetically Engineered Feedstuffs and Sources of Non-Genetically Engineered Feedstuffs · p. 11

    Three of the top 5 corn exporting countries-the United States, Brazil, and Argentina-currently grow GE corn.

    “Three of the top 5 corn exporting countries-the United States, Brazil, and Argentina-currently grow GE corn.”
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    Findingown data
    § Dairy · p. 16

    During 2011, approximately 254,700 dairy cows (2.78% of the total U.S. dairy herd) on 1,848 dairy operations were certified organic.

    “During 2011, approximately 254,700 dairy cows (2.78% of the total U.S. dairy herd; Table 2) on 1,848 dairy operations were certified organic.”
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    § Soybean Meal Production, Imports, Exports and Feed by Country 2013 · p. 13

    China has a zero-tolerance policy for unapproved events.

    “China has a zero-tolerance policy for unapproved events.”
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    § Current U.S. Options for Products from Non-Genetically Engineered Fed Livestock · p. 15

    The countries with the fastest growth in organic production are those that produce organic products for export including China, Bolivia, Chile, Uruguay, and Ukraine.

    “The countries with the fastest growth in organic production are those that produce organic products for export including China, Bolivia, Chile, Uruguay, and Ukraine.”
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    • cites Grow and Greene, 2009

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    § Current U.S. Options for Products from Non-Genetically Engineered Fed Livestock · p. 15

    In 2013, the United States imported over $100 million of organic soybeans primarily from China and India.

    “In 2013, the United States imported over $100 million of organic soybeans primarily from China and India (Fig.  8; Global Agricultural Trade System online [GATS] organic products www.fas.usda. gov/commodities/organic-products).”
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    • cites Fig. 8; Global Agricultural Trade System online [GATS] organic products www.fas.usda. gov/commodities/organic-products

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    § Soybean Meal Production, Imports, Exports and Feed by Country 2013 · p. 13

    The main driver for non-GE feed is the poultry sector (17%) followed by the cattle (9%) and pig sectors (2%).

    “The main driver for non-GE feed is the poultry sector (17%) followed by the cattle (9%) and pig sectors (2%; European Feed Manufacturers' Federation, 2013).”
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    • cites European Feed Manufacturers' Federation, 2013

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    § Current U.S. Options for Products from Non-Genetically Engineered Fed Livestock · p. 15

    The proportion of organic imports used for livestock feed versus human food purposes is unavailable as import product codes do not distinguish between these uses.

    “The proportion of organic imports used for livestock feed versus human food purposes is unavailable as import product codes do not distinguish between these uses.”
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    § Current U.S. Options for Products from Non-Genetically Engineered Fed Livestock · p. 15

    In 2007, USDA-accredited groups certified 27,000 producers and handlers worldwide to the U.S. organic standard, with approximately 16,000 in the United States and 11,000 in over 100 foreign countries.

    “In 2007, USDA-accredited groups certified 27,000 producers and handlers worldwide to the U.S. organic standard, with approximately 16,000 in the United States and 11,000 in over 100 foreign countries (Grow and Greene, 2009).”
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    § 2013 Data on Global Production and Trade in Genetically Engineered Feedstuffs and Sources of Non-Genetically Engineered Feedstuffs · p. 11

    Of the top 5 corn importing countries-Japan, Mexico, the EU, South Korea, and Egypt-only 5 countries within the EU (Spain, Portugal, Romania, Czechoslovakia, and Slovakia) grew a small amount (148,013 ha) of BtMON810 corn.

    “Of the top 5 corn importing countries-Japan, Mexico, the EU, South Korea, and Egypt-only 5 countries within the EU (Spain, Portugal, Romania, Czechoslovakia, and Slovakia) grew a small amount (148,013 ha) of BtMON810 corn (USDA Foreign Agricultural Service, 2014a).”
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    • cites USDA Foreign Agricultural Service, 2014a

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    § 2013 Data on Global Production and Trade in Genetically Engineered Feedstuffs and Sources of Non-Genetically Engineered Feedstuffs · p. 11

    Corn is the second largest category of GE products imported into the EU after soy.

    “Corn is the second largest category of GE products imported into the EU after soy.”
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    § Current U.S. Options for Products from Non-Genetically Engineered Fed Livestock · p. 15

    Consumers wishing to purchase products from animals fed non-GE diets in the United States currently have that choice available through certified NOP products, the FSIS-approved Non-GMO Project verified label claim for meat and liquid eggs, and other non-GMO certification programs.

    “Consumers wishing to purchase products from animals fed non-GE diets in the United States currently have that choice available through certified NOP prod -ucts, the FSIS-approved Non-GMO Project verified label claim for meat and liquid eggs, and other non-genetically modified organism certification programs.”
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    Findingcitation
    § Soybean Meal Production, Imports, Exports and Feed by Country 2013 · p. 13

    In 2007, asynchronous approval of a GE corn variety approved for cultivation in Argentina but unapproved for food and feed use in the EU concentrated demand on corn grown in Brazil, which increased prices an estimated €50/million t for compound feed producers in the EU.

    “Similarly, in 2007 there was a problem with asynchronous approval of a GE corn variety approved for cultivation in Argentina but unapproved for food and feed use in the EU. This concentrated demand on corn grown in Brazil, which in -creased prices an estimated €50/million t for compound feed producers in the EU (Popp et al., 2013).”
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    • cites Popp et al., 2013 source

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    § Soybean Meal Production, Imports, Exports and Feed by Country 2013 · p. 13

    Farm animal feed in the EU-27 is composed of 50% roughages and 10% grains produced on farm, 10% purchased feed materials, and 30% industrial compound feed.

    “Farm animal feed in the 27 member states of the European Union (EU-27) is composed of 50% roughages and 10% grains produced on farm, 10% purchased feed materials, and 30% industrial compound feed.”
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    Findingnone given
    § Corn by Country - Production, Imports, Export, Feed 2013 · p. 14

    China only accepts GE-positive cargo if the shipment is marked accordingly and contains only those GE events that are approved for import in China as well as cultivation in the country of origin.

    “China only accepts GE-positive cargo if the shipment is marked accordingly and contains only those GE events that are approved for import in China as well as cultivation in the country of origin.”
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    Findingcitation
    § Corn by Country - Production, Imports, Export, Feed 2013 · p. 14

    In 2013, 4 major United Kingdom food supermarket groups-Tesco, Cooperative, Marks and Spencer, and Sainsbury's-ceased requiring that poultry and egg suppliers use only non-GE feed.

    “In 2013, 4 major United Kingdom food supermarket groups-Tesco, Cooperative, Marks and Spencer, and Sainsbury's-ceased requiring that poultry and egg suppliers use only non-GE feed (Popp et al., 2013).”
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    • cites Popp et al., 2013 source

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    § Current U.S. Options for Products from Non-Genetically Engineered Fed Livestock · p. 15

    In March 2013, Whole Foods Market set a deadline that by 2018, animal products sold in its U.S. and Canadian stores must be labeled to indicate whether or not they came from animals that had consumed GE feed.

    “For example, in March 2013, the retail chain Whole Foods Market set a deadline that by 2018, animal products sold in its U.S. and Canadian stores must be labeled to indicate whether or not they came from animals that had consumed GE feed (Whole Foods Market, 2013).”
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    • cites Whole Foods Market, 2013

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    Findingnone given
    § Soybean Meal Production, Imports, Exports and Feed by Country 2013 · p. 13

    Since trade disruptions began, a total of 3.3 million t of U.S. corn have been subject to rejection and diverted shipments (1.4 million t) or canceled or deferred sales.

    “Since these trade disruptions began, a total of 3.3 million t of U.S. corn have been subject to re-”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingnone given
    § Dairy · p. 16

    Organically raised livestock accounted for $1.31 billion in sales in 2011.

    “Organically raised livestock accounted for $1.31 billion in sales in 2011, the last year with a complete set of data on production and sales.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingnone given
    § Soybean Meal Production, Imports, Exports and Feed by Country 2013 · p. 13

    Of the top 5 soybean meal exporting countries in 2013-Argentina, Brazil, the United States, India, and Paraguay-only India does not allow the cultivation of GE soybeans.

    “Of the top 5 soybean meal exporting countries in 2013-Argentina, Brazil, the United States, India, and Paraguay-only India does not allow the cultivation of GE soybeans.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingnone given
    § 2013 Data on Global Production and Trade in Genetically Engineered Feedstuffs and Sources of Non-Genetically Engineered Feedstuffs · p. 11

    The remaining 2 top 5 corn exporting countries-Ukraine and India-do not have officially registered and approved GE corn varieties.

    “The remaining 2 countries-Ukraine and India-do not have officially registered and approved GE corn varieties.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingcitation
    § Current U.S. Options for Products from Non-Genetically Engineered Fed Livestock · p. 15

    In 2007, approximately half of the accredited foreign organic farmers and handlers certified to NOP standards were in Canada, Italy, Turkey, China, and Mexico.

    “In 2007, approximately half of the accredited foreign organic farmers and handlers certified to NOP standards were in Canada, Italy, Turkey, China, and Mexico.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Grow and Greene, 2009

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Findingcitation
    § 2013 Data on Global Production and Trade in Genetically Engineered Feedstuffs and Sources of Non-Genetically Engineered Feedstuffs · p. 11

    Annual EU imports of corn products include US$1.8 billion of corn, $151 million of corn seed for planting, and $87 million of dried distillers grains.

    “Annual EU imports of corn products include US$1.8 billion of corn, $151 million of corn seed for planting, and $87 million of dried distillers grains (USDA Foreign Agricultural Service, 2013a).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites USDA Foreign Agricultural Service, 2013a

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Findingcitation
    § Soybean Meal Production, Imports, Exports and Feed by Country 2013 · p. 13

    In the EU, less than 15% of the animal feed market is identity-preserved certified non-GE, although there are great variations between countries.

    “It has been estimated that in the EU, less than 15% of the animal feed market is identity-preserved certified non-GE, although there are great variations between countries.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingown data
    § Soybean Meal Production, Imports, Exports and Feed by Country 2013 · p. 13

    The estimated size of the export market requiring certified non-GE corn is 7.3 million t or 7%.

    “The estimated size of the export market requiring certified non-GE corn is 7.3 million t or 7% (Table 6).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Table 6

      Not checked in the free run.

  • May combine two claims.

    Findingnone given
    § 2013 Data on Global Production and Trade in Genetically Engineered Feedstuffs and Sources of Non-Genetically Engineered Feedstuffs · p. 11

    EU corn production is sufficient to meet most of its own corn consumption, with imports accounting for only 10% of total supply.

    “Unlike soybean, EU corn production is sufficient to meet most of its own corn consumption, with imports accounting for only 10% of total supply.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingcitation
    § Corn by Country - Production, Imports, Export, Feed 2013 · p. 14

    Up to $2.9 billion in economic losses were sustained by the U.S. corn, distillers' grains, and soy sectors in the aftermath of the zero-tolerance enforcement policy on U.S. export shipments to China.

    “It has been estimated that up to $2.9 billion in economic losses were sustained by the U.S. corn, distillers' grains, and soy sectors in the aftermath of the ze -ro-tolerance enforcement policy on U.S. export shipments to China (National Grain and Feed Association, 2014).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites National Grain and Feed Association, 2014

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based). May combine two claims.

    Findingnone given
    § Corn by Country - Production, Imports, Export, Feed 2013 · p. 14

    Ukraine does not export or import GE products as none are officially registered and approved for commercial use or sale in the country.

    “Ukraine does not export or import GE products as none are officially registered and approved for commer -cial use or sale in the country.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingnone given
    § 2013 Data on Global Production and Trade in Genetically Engineered Feedstuffs and Sources of Non-Genetically Engineered Feedstuffs · p. 11

    Approximately 11.6% (100 million t) of global corn production was internationally traded in 2013.

    “Approximately 11.6% (100 million t) of global corn production was internationally traded in 2013.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingcitation
    § Dairy · p. 16

    Less than 2% of U.S. dairy production is currently organic.

    “Organic milk led livestock commodities, accounting for $765 million, or 58%, of organic animal product sales; however, less than 2% of U.S. dairy production is currently organic (Hafla et al., 2013).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Hafla et al., 2013 source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingnone given
    § Corn by Country - Production, Imports, Export, Feed 2013 · p. 14

    Ukraine signed a 3-yr agreement with China in 2013 for the delivery of 4 to 5 million t of corn per year.

    “Interestingly, Ukraine signed a 3-yr agreement with China in 2013 for the delivery of 4 to 5 million t of corn per year.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Findingcitation
    § Corn by Country - Production, Imports, Export, Feed 2013 · p. 14

    Private sources estimate approximately 60% of the Ukraine soybean crop and 30% of the corn crop consist of GE varieties.

    “However, private sources estimate approximately 60% of the Ukraine soybean crop and 30% of the corn crop consist of GE varieties (USDA Foreign Agricultural Service, 2013b).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites USDA Foreign Agricultural Service, 2013b

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingcitation
    § Dairy · p. 16

    The retail price for organic milk between 2004 and 2007 averaged 3 times the cost of conventional milk.

    “The retail price for or -ganic milk between 2004 and 2007 averaged 3 times the cost of conventional milk (USDA Economic Research Service, 2012b), and in 2013, organic milk made up 4.38% of total U.S. fluid milk market sales.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites USDA Economic Research Service, 2012b

      Not checked in the free run.

  • May combine two claims.

    Findingnone given
    § Poultry · p. 17

    In 2011, sales of U.S. organic broilers and eggs totaled $115 million and $276 million, representing 0.5 and 3.7% of total sales, respectively.

    “In 2011, sales of U.S. organic broilers and eggs totaled $115 million and $276 million, representing 0.5 and 3.7% of total sales, respectively.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingcitation
    § The Future · p. 18

    Several of these crops are far advanced in the regulatory pipeline.

    “Several of these crops are far advanced in the regulatory pipeline (Table 8; Tillie et al., 2013)”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Table 8; Tillie et al., 2013

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Findingcitation
    § Impact of Genetically Engineered Feedstuffs on the Sustainability of Livestock Production · p. 17

    In 2013, approximately 175.2 million ha of GE crops were cultivated worldwide by 18 million farmers.

    “In 2013, approximately 175.2 million ha of GE crops were cultivated worldwide (James, 2013) by 18 million farmers.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites James, 2013

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Findingnone given
    § Beef · p. 16

    The price of natural/organic beef averaged $12.08/kg in the first quarter of 2011, which represented a premium of $3.75/kg.

    “The price of natural/organic beef averaged $12.08/kg in the first quarter of 2011, which represent -ed a premium of $3.75/kg.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Findingnone given
    § Impact of Genetically Engineered Feedstuffs on the Sustainability of Livestock Production · p. 17

    In China, 7.5 million farmers cultivating an average of approximately 0.5 ha collectively grew 4.2 million ha of Bt cotton, an adoption rate of 90%.

    “In China, 7.5 million farmers cultivating an average of approximately 0.5 ha collectively grew 4.2 million ha of Bt cotton, an adoption rate of 90%.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Findingnone given
    § Beef · p. 16

    Organic beef cattle may be finished in feedlots for no more than 120 d and must have access to pasture during this time.

    “Organic beef cattle may be finished in feedlots for no more than 120 d and must have access to pasture during this time.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingcitation
    § Beef · p. 16

    Natural, organic, and grass/forage-fed account for about 3% of the U.S. beef market.

    “Natural, organic (grain-fed or otherwise), and grass/ forage-fed (including cattle finished on grasses/forages to a specific quality standard) account for about 3% of the U.S. beef market (Mathews and Johnson, 2013).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Mathews and Johnson, 2013

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingcitation
    § The Future · p. 18

    Currently, 33 countries have regulatory systems that handle approval for the cultivation or importation of new GE crops.

    “Currently, 33 countries have regulatory systems that handle approval for the cultivation or importation of new GE crops (International Service for the Acquisition of Agri-Biotech Applications, 2014).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites International Service for the Acquisition of Agri-Biotech Applications, 2014

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingcitation
    § Beef · p. 16

    Silage is an accepted feed that can consist of relatively large portions of grain.

    “However, silage is an accepted feed that can consist of relatively large portions of grain.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingnone given
    § Beef · p. 16

    Under the AMS Process Verified Program grass-fed standard, grass or forage must be the exclusive feed source throughout the lifetime of the ruminant animal except for milk consumed before weaning.

    “Under this verification standard, grass or forage must be the exclusive feed source throughout the lifetime of the ruminant animal except for milk consumed before weaning.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingnone given
    § Beef · p. 16

    The USDA NE3 Process Verified Program does not mandate or specify the use of non-GE feed.

    “Likewise, the USDA NE3 Process Verified Program does not mandate or specify the use of non-GE feed.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingcitation
    § The Future · p. 18

    There are numerous GE crops enhanced for animal nutrition in the research and development pipeline, with almost 100 events under research in many countries.

    “There are numerous GE crops enhanced for animal nutrition in the research and development pipeline, with almost 100 events under research in many countries of the world (Tillie et al., 2013).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Tillie et al., 2013 source

      Not checked in the free run.

  • May combine two claims.

    Findingcitation
    § Impact of Genetically Engineered Feedstuffs on the Sustainability of Livestock Production · p. 17

    By 2020, developing countries will consume 107 million t more meat and 177 million t more milk than the annual average of the years 1996 through 1998.

    “By 2020, developing countries will consume 107 million t more meat and 177 million t more milk than the annual average of the years 1996 through 1998.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Delgado, 2003 source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingcitation
    § The Future · p. 18

    Protocols have been developed to address the safety testing of these crops.

    “Protocols have been developed to address the safety testing of these crops (International Life Sciences Institute, 2007).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites International Life Sciences Institute, 2007

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingnone given
    § Poultry · p. 17

    The largest volume of organic meat sales is for poultry.

    “The largest volume of organic meat sales is for poultry.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Findingown data
    § Beef · p. 16

    In 2011, 106,181 beef cows (0.34% of the total U.S. beef cows) and 113,114 unclassified cows and young stock were raised in certified organic production systems.

    “In 2011, 106,181 beef cows (0.34% of the total U.S. beef cows; Table 2) and 113,114 unclassified cows and young stock were raised in certified organic production systems.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Table 2

      Not checked in the free run.

  • May combine two claims.

    Findingcitation
    § Impact of Genetically Engineered Feedstuffs on the Sustainability of Livestock Production · p. 18

    GE crops have resulted in a significant reduction in greenhouse gas emissions, which in 2012 alone was equivalent to removing 11.88 million cars from the roads.

    “As a result of fuel savings associated with making fewer spray runs, the adoption of production systems with reduced tillage, and additional soil carbon sequestration, GE crops have also resulted in a significant reduction in the release of greenhouse gas emissions, which, in 2012 alone, was equivalent to removing 11.88 million cars from the roads (Brookes and Barfoot, 2014b).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Brookes and Barfoot, 2014b

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingreasoning
    § Impact of Genetically Engineered Feedstuffs on the Sustainability of Livestock Production · p. 17

    Over 90% (>16.5 million) of these farmers were small-scale, resource-poor farmers in developing countries.

    “Over 90% (&gt;16.5 million) were small-scale, resource-poor farmers in developing countries.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingown data
    § Poultry · p. 17

    In 2011, certified organic broilers totaled more than 28 million (0.33% of total U.S. broilers), layer hens totaled more than 6.6 million (1.97% of total U.S. layers), and turkeys totaled 504,000 (0.20% of total U.S. turkeys).

    “In 2011, the number of certified organic broilers totaled more than 28 million (0.33% of the total U.S. broilers; Table 2), layer hens totaled more than 6.6 million (1.97% of the total U.S. layers), and turkeys totaled 504,000 (0.20% of the total U.S. turkeys).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Table 2

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Findingcitation
    § Beef · p. 16

    The animal cannot be fed grain or any grain byproduct before marketing and must have continuous access to pasture during the growing season.

    “The animal cannot be fed grain or any grain byproduct before marketing and must have continuous access to pasture during the growing season.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Findingnone given
    § Impact of Genetically Engineered Feedstuffs on the Sustainability of Livestock Production · p. 17

    India cultivated 11.0 million ha of Bt cotton with an adoption rate of 95%.

    “India cultivated 11.0 million ha of Bt cotton with an adoption rate of 95%.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingcitation
    § Dairy · p. 16

    In 2013, organic milk made up 4.38% of total U.S. fluid milk market sales.

    “The retail price for or -ganic milk between 2004 and 2007 averaged 3 times the cost of conventional milk (USDA Economic Research Service, 2012b), and in 2013, organic milk made up 4.38% of total U.S. fluid milk market sales.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingcitation
    § Poultry · p. 17

    The retail price for organic poultry and eggs between 2004 and 2006 was approximately twice that of conventional products.

    “The retail price for organic poultry and eggs between 2004 and 2006 was approximately twice that of conventional products (USDA Economic Research Service, 2012a).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites USDA Economic Research Service, 2012a

      Not checked in the free run.

  • May combine two claims.

    Findingcitation
    § Beef · p. 16

    Corn silage averages 10 to 20% grain and can consist of up to a third or more grain, blurring the distinction between grain fed and forage fed.

    “For example, corn silage, which averages 10 to 20% grain and can consist of up to a third or more grain, blurs the distinction between grain fed and forage fed (Mathews and Johnson, 2013).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Mathews and Johnson, 2013

      Not checked in the free run.

  • May combine two claims.

    Findingnone given
    § Poultry · p. 17

    Voluntary labeling programs and market premiums exist for products derived from animals that have not consumed GE feed.

    “V oluntary labeling programs and market premiums exist for products derived from animals that have not consumed GE feed.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Findingcitation
    § The Future · p. 18

    Sampling, testing, and certification depend on statistical processes, and hence all are subject to some error, which increases at very low tolerances.

    “Sampling, testing, and certification depend on statistical processes, however, and hence all are subject to some error, which increases at very low tolerances (Lamb and Booker, 2011).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Lamb and Booker, 2011

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based). May combine two claims.

    Findingnone given
    § The Future · p. 18

    Currently, the most accepted techniques for the detection of rDNA and protein products are PCR and ELISA, respectively.

    “Currently, the most accepted techniques for the detection of rDNA and protein products are PCR and ELISA, respectively.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Findingcitation
    § The Future · p. 18

    Although efforts have been taken to harmonize analytical methodology for the detection of GE products at national, regional, and international levels, no international standards have yet been established.

    “Although efforts have been taken to harmonize analytical methodology for the detection of GE products at national, regional, and international levels, no international standards have yet been established (Holst-Jensen et al., 2006).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Holst-Jensen et al., 2006 source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S4 (based).

    Findingnone given
    § Conclusions · p. 20

    Global trade of livestock feed is largely supplied by countries that have approved the cultivation of GE crops.

    “Animal agriculture is currently highly dependent on GE feed sources, and global trade of livestock feed is largely supplied by countries that have approved the cultivation of GE crops.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S4 (based).

    Findingnone given
    § Conclusions · p. 20

    Commercial livestock populations are the largest consumers of GE crops.

    “Commercial livestock populations are the largest consumers of GE crops, and globally, billions of animals have been eating GE feed for almost 2 decades.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingcitation
    § The Future · p. 18

    Various analytical methods have been developed and are routinely used for the monitoring of GE origin in raw materials and processed foods.

    “Various analytical methods have been developed and are routinely used for the monitoring of GE origin in raw materials and processed foods and have been reviewed elsewhere (Alexander et al., 2007; Marmiroli et al., 2008).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Alexander et al., 2007; Marmiroli et al., 2008

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S4 (based).

    Findingnone given
    § Conclusions · p. 20

    There is currently a pipeline of so-called 'second generation' GE crops with improved output traits for livestock production.

    “There is currently a pipeline of so-called 'second generation' GE crops with improved output traits for livestock production.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingreasoning
    § Conclusions · p. 20

    The cost of non-GE-fed animal products is higher than conventionally produced products due to both the higher cost of non-GE feed and the costs associated with certifying the absence of GE crops in the production process and product segregation.

    “The cost of these products is higher than conventionally produced products due to both the higher cost of non-GE feed and the costs associated with certifying the absence of GE crops in the production process and product segregation.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingnone given
    § Conclusions · p. 20

    Such products are available to interested consumers via voluntary process-based marketing programs.

    “The market for animals that have not consumed GE feed is currently a niche market in the United States, although such products are available to interested consumers via voluntary processbased marketing programs.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Premisecitation
    § Introduction · p. 1

    No significant differences in feed digestibility, performance, or health have been observed in livestock that consume GE feed.

    “no significant differences in feed digestibility, performance, or health have been observed in livestock that consume GE feed (Flachowsky et al., 2012).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Flachowsky et al., 2012 source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation
    § Livestock Feeding Studies with Genetically Engineered Feed · p. 2

    The European Food Safety Authority states that 90-day subchronic rodent testing is only warranted when driven by a specific hypothesis indicated by molecular, compositional, phenotypic, agronomic, or other analysis of the particular GE event.

    “the European Food Safety Authority (2008; Parma, Italy) states that such testing is only warranted when driven by a specific hypothesis indicated by mo -lecular, compositional, phenotypic, agronomic, or other analysis (e.g., metabolic pathway considerations) of the particular GE event.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites European Food Safety Authority, 2008 source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation
    § Livestock Feeding Studies with Genetically Engineered Feed · p. 3

    Results from comprehensive studies revealed the compositional and nutritional noninferiority of GE corn to its isogenic control and an absence of long-term adverse effects from GE corn consumption.

    “Results from these comprehensive studies revealed the compositional and nutritional noninferiority of GE corn to its isogenic control and an absence of long-term adverse effects from GE corn consumption.”
    Quote in the paperSubstantial claim0 of 3 sources checked
    • cites Guertler et al., 2010, 2012

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites Steinke et al., 2010 source

      Not checked in the free run.

    • cites Walsh et al., 2011 source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation
    § Livestock Feeding Studies with Genetically Engineered Feed · p. 2

    The poison alpha-solanine was unintentionally increased to unacceptable levels in certain varieties of potato through plant breeding, resulting in certain cultivars being withdrawn from the United States and Swedish markets.

    “α-solanine, a glycoalkaloid, was unintentionally increased to unacceptable levels in certain varieties of potato through plant breeding resulting in certain cultivars being withdrawn from the U.S. and Swedish markets due to frequently exceeding the upper safe limit for total glycoalkaloid content (Petersson et al., 2013).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Petersson et al., 2013 source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation
    § Livestock Feeding Studies with Genetically Engineered Feed · p. 2

    Many toxicologists concur that animal feeding trials of whole GE food have low power to detect adverse effects and contribute little to the safety assessment of whole foods.

    “Many toxicologists concur that animal feeding trials of whole GE food have a low power to detect adverse effects and contribute little, if anything, to the safety assessment of whole foods (Kuiper et al., 2013).”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Kuiper et al., 2013 source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation
    § Livestock Feeding Studies with Genetically Engineered Feed · p. 3

    Antibodies specific to the GE corn protein Cry1Ab were not detected in the blood, indicating the absence of an allergic-type immune response to the protein.

    “Antibodies specific to the GE corn protein (Cry1Ab) were not detected in the blood, indicating the absence of an allergic-type immune response to the protein.”
    Quote in the paperSubstantial claim0 of 3 sources checked
    • cites Guertler et al., 2010, 2012

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites Steinke et al., 2010 source

      Not checked in the free run.

    • cites Walsh et al., 2011 source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation
    § Livestock Feeding Studies with Genetically Engineered Feed · p. 3

    Neither the cry1Ab gene nor the Cry1Ab protein was found in the blood, organs, or products of animals fed GE corn.

    “Neither the cry1Ab gene nor the Cry1Ab protein was found in the blood, organs, or products of animals fed GE corn”
    Quote in the paperSubstantial claim0 of 3 sources checked
    • cites Guertler et al., 2010, 2012

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites Steinke et al., 2010 source

      Not checked in the free run.

    • cites Walsh et al., 2011 source

      Not checked in the free run.

  • May combine two claims.

    Interpretationreasoning
    § Livestock Feeding Studies with Genetically Engineered Feed · p. 3

    Neither the intact recombinant DNA nor the intact recombinant protein migrated from the digestive system of the animal into other body tissues or edible animal products.

    “indicating that neither the intact rDNA nor the intact recombinant protein migrated from the digestive system of the animal into other body tissues or edible animal products.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation
    § Livestock Feeding Studies with Genetically Engineered Feed · p. 3

    The European Food Safety Authority clarified the difference between statistical significance and biological relevance.

    “The European Food Safety Authority clarified the difference between statis -tical significance and biological relevance (European Food Safety Authority, 2011).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites European Food Safety Authority, 2011

      Not checked in the free run.

  • May combine two claims.

    Premisecitation
    § Livestock Feeding Studies with Genetically Engineered Feed · p. 3

    There were no adverse effects of feeding GE corn on small intestinal morphology or the gut microbiota.

    “there were no adverse effects of feeding GE corn on small intestinal morphology or the gut microbiota.”
    Quote in the paperSubstantial claim0 of 3 sources checked
    • cites Guertler et al., 2010, 2012

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites Steinke et al., 2010 source

      Not checked in the free run.

    • cites Walsh et al., 2011 source

      Not checked in the free run.

  • Classified as probably not a substantial claim.

    Interpretationreasoning
    § Field Datasets of Livestock Populations Fed with Genetically Engineered Feed · p. 7

    The feed conversion ratio would be expected to worsen (increase) if the health of broilers was deteriorating following exposure to GE feed.

    “but this ratio is something that would be expected to worsen (i.e., increase) if the health of these animals was deteriorating following exposure to GE feed.”
    Quote in the paperSubstantial claim
    • The authors state this as an assumption: If animal feed derived from GE crops had deleterious effects on animals consuming GE feed, then animal performance and health attributes in these large commercial livestock populations would have been negatively impacted.
  • May combine two claims.

    Premisecitation
    § Summary of Data on Recombinant DNA/protein in Milk, Meat, and Eggs from Animals Fed Genetically Engineered Feed · p. 9

    Studies have concluded that animals do not digest transgenic and native plant DNA differently and that rDNA from GE crops has not been detected in animal products.

    “Studies have concluded that animals do not digest transgenic and native plant DNA differently and that rDNA from GE crops has not been detected in animal products (Einspanier, 2013).”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Einspanier, 2013 source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation
    § Field Datasets of Livestock Populations Fed with Genetically Engineered Feed · p. 7

    Broilers are exposed to large amounts of corn and soybean meal during their 42- to 49-d lifespan and increase their body size 60-fold during this period, making them very sensitive to dietary perturbations.

    “Although broilers are exposed to large amounts of corn and soybean meal during their 42- to 49-d lifespan, they increase their body size 60fold during this period, making them very sensitive to dietary perturbations (European Food Safety Authority, 2008; International Life Sciences Institute, 2003).”
    Quote in the paperSubstantial claim0 of 2 sources checked
    • cites European Food Safety Authority, 2008 source

      Not checked in the free run.

    • cites International Life Sciences Institute, 2003

      Not checked in the free run.

    • Rests on an assumption: In a typical U.S. broiler operation, chickens are fed for 42–49 d on diets composed of approximately 35% soybean meal and 65% corn grain.
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisenone given
    § Field Datasets of Livestock Populations Fed with Genetically Engineered Feed · p. 8

    Adverse effects, including high rates of tumorogenesis, sterility, premature mortality, and histopathological abnormalities, have been reported in these studies.

    “Adverse effects, including high rates of tumorogenesis, sterility, premature mortality, and histopathological abnormalities have been reported.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Premisecitation
    § Summary of Data on Recombinant DNA/protein in Milk, Meat, and Eggs from Animals Fed Genetically Engineered Feed · p. 9

    Neither recombinant DNA nor protein has ever been found in milk, meat, or eggs from animals that have eaten GE feed, with the exception of a single study that reported fragments of transgenic DNA in both 'organic' and 'conventional' milk in Italy.

    “however, neither recombinant DNA nor protein has ever been found in milk, meat, or eggs from animals that have eaten GE feed with the exception of a single study that reported the presence of fragments of transgenic DNA in both 'organic' and 'conventional' milk in Italy (Agodi et al., 2006).”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Agodi et al., 2006 source

      Not checked in the free run.

  • May combine two claims.

    Premisecitation
    § Field Datasets of Livestock Populations Fed with Genetically Engineered Feed · p. 8

    Some of these reports were published and then retracted, and others were never subjected to peer review.

    “Some of these reports were published and then retracted (Séralini et al., 2012), although recently and controversially republished without further peer review (Séralini et al., 2014), and others were never subjected to peer review (Ermakova, 2005; Velmirov et al., 2008).”
    Quote in the paperNot a substantial claim0 of 3 sources checked
    • cites Séralini et al., 2012 source

      Not checked in the free run.

    • cites Séralini et al., 2014 source

      Not checked in the free run.

    • cites Ermakova, 2005

      Not checked in the free run.

  • May combine two claims.

    Premisecitation
    § Summary of Data on Recombinant DNA/protein in Milk, Meat, and Eggs from Animals Fed Genetically Engineered Feed · p. 9

    The DNA from GE crops is chemically equivalent to DNA from other sources and both are thoroughly broken down in the gastrointestinal tract during digestion.

    “The DNA from GE crops is chemically equivalent to DNA from other sources and both are thoroughly broken down in the gastrointestinal tract during digestion (Beever and Kemp, 2000; Jonas et al., 2001; CAST, 2006).”
    Quote in the paperSubstantial claim0 of 3 sources checked
    • cites Beever and Kemp, 2000

      Not checked in the free run.

    • cites Jonas et al., 2001 source

      Not checked in the free run.

    • cites CAST, 2006

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Interpretationcitation
    § 2013 Data on Global Production and Trade in Genetically Engineered Feedstuffs and Sources of Non-Genetically Engineered Feedstuffs · p. 11

    Increase in demand for animal products, especially meat, will drive demand for grain and protein feeds.

    “Increase in demand for animal products, especially meat, will drive demand for grain and protein feeds (USDA Economic Research Service, 2008).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites USDA Economic Research Service, 2008

      Not checked in the free run.

  • May combine two claims.

    Premisecitation
    § Field Datasets of Livestock Populations Fed with Genetically Engineered Feed · p. 9

    Despite a wealth of studies and literature to the contrary, these isolated and poorly designed studies have resulted in the promulgation of new regulations, including a mandatory 90-d rodent subchronic toxicity feeding study for all new GE approvals in the EU, and have generated a great deal of media attention.

    “Despite a wealth of studies and literature to the contrary, these isolated and poorly designed studies have resulted in the promulgation of new regulations, including a mandatory 90-d rodent subchronic toxicity feeding study for all new GE approvals in the EU (Kuiper et al., 2013), and have generated a great deal of media attention (Arjó et al., 2013).”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites Kuiper et al., 2013 source

      Not checked in the free run.

    • cites Arjó et al., 2013 source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation
    § 2013 Data on Global Production and Trade in Genetically Engineered Feedstuffs and Sources of Non-Genetically Engineered Feedstuffs · p. 11

    FAO predicts that by 2050 global grain trade will double to 600 million t.

    “The Food and Agriculture Organization of the United Nations (Rome, Italy) predicts that by 2050 global grain trade will double to 600 million t (Bruinsma 2009).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Bruinsma 2009

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Interpretationreasoning
    § Soybean Meal Production, Imports, Exports and Feed by Country 2013 · p. 13

    U.S. GE corn plantings caused a drastic decline in corn exports to the EU because of trade disruptions due to asynchronous approvals.

    “The United States used to be a major supplier of corn to the EU in the 1990s but GE corn plantings in the United States caused a drastic decline in corn exports to the EU because of trade disruptions due to asynchronous approvals (i.e., cultivation approvals of specific GE varieties in the United States occurring before food and feed import approvals in the EU).”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Interpretationreasoning
    § Corn by Country - Production, Imports, Export, Feed 2013 · p. 14

    Given asynchronous regulatory approvals and shared harvesting machinery and storage facilities, trade disruption appears almost unavoidable if importing countries enforce a zero-tolerance policy for unapproved events that have been approved for cultivation in exporting countries.

    “Given asynchronous regulatory approvals and the realities of agricultural production systems where harvesting machinery and storage facilities are shared among different production systems, trade disruption appears almost unavoidable if importing countries enforce a 'zerotolerance' policy for unapproved events that have been approved for cultivation in exporting countries.”
    Quote in the paperNot a substantial claim
    • Rests on an assumption: Harvesting machinery and storage facilities are shared among different agricultural production systems.
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Interpretationcitation
    § Corn by Country - Production, Imports, Export, Feed 2013 · p. 14

    As global production of GE feed crops continues to rise, the EU's stringent GE tolerance levels (0.9% GE material limit plus 0.05% measuring uncertainty tolerance) and zero tolerance for unapproved events are complicating the maintenance of non-GE supply chains.

    “As the global production of GE feed crops continues to rise, the EU's stringent GE tolerance levels (0.9% GE material limit plus 0.05% measuring uncertainty tolerance) and zero tolerance for unapproved events are complicating the maintenance of non-GE supply chains (Popp et al., 2013).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Popp et al., 2013 source

      Not checked in the free run.

  • May combine two claims.

    Interpretationreasoning
    § Current U.S. Options for Products from Non-Genetically Engineered Fed Livestock · p. 15

    The availability and cost of certified organic feeds is a major challenge for U.S. organic livestock producers.

    “The availability and cost of certified organic feeds is a major challenge for U.S. or -ganic livestock producers.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Interpretationreasoning
    § Dairy · p. 16

    Production costs for organic dairies are greater than for conventional dairies due to the increased cost of organic feed and the increased use of labor and capital, which is not scale neutral as total costs per unit of production drops sharply as herd size increases.

    “Production costs for organic dairies are greater than for conventional dairies due to the increased cost of organic feed and the increased use of labor and capital, which is not scale neutral as the total costs per unit of production drops sharply as herd size increases.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Interpretationnone given
    § Current U.S. Options for Products from Non-Genetically Engineered Fed Livestock · p. 15

    Voluntary process-based labels verify that GE crops were not used in the production process, rather than testing for the presence of GE content in the animal products themselves, as such products contain no detectable and quantifiable traces of GE materials.

    “These voluntary process-based labels, in effect, verify that GE crops were not used in the production process, rather than testing for the presence of GE content in the animal products themselves as such products contain no detectable and quantifiable traces of GE materials.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).

    Interpretationnone given
    § Current U.S. Options for Products from Non-Genetically Engineered Fed Livestock · p. 15

    Given high rates of GE adoption in major feed crops, U.S. producers wishing to purchase non-GE feed likely contract with growers or source identity-preserved (certified non-GE) or organic feed.

    “Given the high rates of GE adoption in major feed crops, U.S. producers wishing to purchase non-GE feed for their livestock likely contract with growers or source identity-preserved (certified non-GE) or organic feed.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Interpretationcitation
    § The Future · p. 18

    Genetic engineering offers new possibilities for approaching both objectives, including improving the nutritional value of feed, lowering N and P pollution through altered crop composition, and reducing manure excretion through a higher NE value.

    “Genetic engineering offers new possibilities for approaching both of these objectives, including improving the nutritional value of feed (e.g., AA content; Huang et al., 2006), lowering N and P pollution through altered crop composition (e.g., low phytate; Chen et al., 2008), and reducing manure excretion through a higher NE value (e.g., reduced lignin; Jung et al., 2012).”
    Quote in the paperNot a substantial claim0 of 3 sources checked
    • cites Huang et al., 2006 source

      Not checked in the free run.

    • cites Chen et al., 2008 source

      Not checked in the free run.

    • cites Jung et al., 2012 source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).

    Interpretationreasoning
    § The Future · p. 18

    Given different regulatory approaches for compositionally equivalent crops, it is unclear how regulatory requirements may vary between countries in terms of the number and length of target animal feeding studies for these crops with altered output traits.

    “However, given the different regulatory approaches that are in place for crops that are compositionally equivalent, it is unclear how regulatory requirements may vary between countries in terms of the number and length of target animal feeding studies for these crops with altered output traits.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Interpretationreasoning
    § The Future · p. 18

    Second generation crops modified for output traits will pose some regulatory and commercialization challenges.

    “These so-called 'second generation' crops modified for output traits will pose some regulatory and com -mercialization challenges.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).

    Premisenone given
    § Impact of Genetically Engineered Feedstuffs on the Sustainability of Livestock Production · p. 17

    Feedstuffs are a major contributor to life cycle assessments in the production of meat, milk, and eggs on a national and global scale.

    “Feedstuffs are a major contributor to life cycle assessments in the production of meat, milk, and eggs on a national and global scale.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Interpretationcitation
    § Poultry · p. 17

    Reversion from GE to conventional crop varieties would require the adoption of altered agronomic practices to manage those crops and relinquishment of the documented environmental and economic benefits associated with the adoption of GE crops.

    “Reversion from GE to conventional crop varieties would require the adoption of altered agronomic practices to manage those crops and relinquishment of the documented environmental and economic benefits as -sociated with the adoption of GE crops (Areal et al., 2013; Fernandez-Cornejo et al., 2014; Green, 2012; NRC, 2010).”
    Quote in the paperSubstantial claim0 of 1 sources checked
    • cites Areal et al., 2013; Fernandez-Cornejo et al., 2014; Green, 2012; NRC, 2010

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Interpretationreasoning
    § Impact of Genetically Engineered Feedstuffs on the Sustainability of Livestock Production · p. 17

    This planting was greater than a 100-fold increase from the 1.7 million ha that were planted in 1996, making GE the fastest-adopted crop technology in recent history.

    “This planting was greater than a 100-fold increase from the 1.7 million ha that were planted in 1996, making GE the fastest-adopted crop technology in recent history.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing), S4 (based).

    Interpretationnone given
    § The Future · p. 18

    If benefits derived from growing these crops accrue to the livestock producer or feeder and not directly to the farmer growing the crop, there will need to be some form of supply chain segregation in place to ensure a price premium is obtained for the value-added output trait.

    “Additionally, if the benefits derived from growing these crops accrue to the livestock producer or feeder and not directly to the farmer growing the crop, there will need to be some form of supply chain segregation in place to ensure a price premium is obtained for the value-added output trait.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisenone given
    § The Future · p. 18

    There are 2 ways in which plant breeding might increase the efficiency of livestock production: raising crop yield per hectare and improving the rate of conversion of vegetable calories into animal calories.

    “There are 2 ways in which plant breeding might increase the efficiency of livestock production; the first is by raising the crop yield per hect -are (e.g., improved drought tolerance or N use efficiency) and the second is by improving the rate of conversion of vegetable calories into animal calories (e.g., altered output traits or crop composition).”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing), S4 (based).

    Interpretationnone given
    § The Future · p. 18

    Second generation crops will not, by definition, be substantially equivalent to isogenic non-GE varieties.

    “The first is that they will not, by definition, be substantially equivalent to isogenic non-GE varieties.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Interpretationcitation
    § Impact of Genetically Engineered Feedstuffs on the Sustainability of Livestock Production · p. 17

    Farmers have planted these GE varieties to enable the adoption of improved agronomic practices (e.g., reduced insecticide applications) providing environmental, economic, and food security benefits in various countries.

    “Farmers have planted these GE varieties to enable the adoption of improved agronomic practices (e.g., reduced insecticide applications) providing environmental, economic, and food security benefits in various countries (Ali and Abdulai, 2010; Burachik, 2010; Fernandez-Cornejo et al., 2014; Huang et al., 2010; Kathage and Qaim, 2012; Qaim and Kouser, 2013).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Ali and Abdulai, 2010; Burachik, 2010; Fernandez-Cornejo et al., 2014; Huang et al., 2010; Kathage and Qaim, 2012; Qaim and Kouser, 2013

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • May combine two claims.

    Interpretationnone given
    § Dairy · p. 16

    Using pasture as a source of dairy forage is more common on organic dairies, which can help reduce feed costs per cow but also contributes to lower production per cow.

    “Using pasture as a source of dairy forage is more common on organic dairies, which can help to reduce feed costs per cow but also contributes to lower production per cow.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Interpretationnone given
    § Beef · p. 16

    The term 'natural' is not associated with an official production process standard so natural beef may come from animals that have consumed GE feed.

    “The term 'natural' is not associated with an official production process standard so natural beef may come from animals that have consumed GE feed.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation
    § The Future · p. 19

    The range of GE crop species being grown and traded is expanding.

    “2) the expanding range of GE crop species being grown and traded;”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Kalaitzandonakes et al. (2014) source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation
    § The Future · p. 19

    The pipeline of novel GE crop events, including second-generation crops modified for output traits, is expanding.

    “These include 1) the expanding pipeline of novel GE crop events, including second generation crops modified for output traits;”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Kalaitzandonakes et al. (2014) source

      Not checked in the free run.

  • May combine two claims.

    Interpretationreasoning
    § The Future · p. 18

    Asynchronous approvals have resulted in trade disruptions, especially when countries use a zero-tolerance policy for unapproved events, meaning that even minute traces of unapproved GE crops are illegal and must be withdrawn from the market.

    “As discussed previously, this has resulted in trade disruptions, especially when countries use a 'zero-tolerance' policy for unapproved events, meaning that even minute traces of unapproved GE crops are illegal and must be withdrawn from the market.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing).

    Interpretationcitation
    § The Future · p. 20

    Recent developments may lead to a revaluation of the current rDNA process-based regulatory trigger for GE organisms to a more scientifically defensible product-based approach centered on the novelty and any unique risks associated with the phenotype of the product rather than the process used to accomplish the genetic modification.

    “These developments may lead to a revaluation of the current rDNA process-based regulatory trigger for GE organisms to a more scientifically defensible product-based approach centered on the novelty and any unique risks associated with the phenotype of the product rather than the process used to accomplish the genetic modification (Bradford et al., 2005; McHughen, 2007).”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites Bradford et al., 2005 source

      Not checked in the free run.

    • cites McHughen, 2007 source

      Not checked in the free run.

  • May combine two claims.

    Interpretationreasoning
    § The Future · p. 18

    Countries with zero-tolerance policies will be perceived as risky export markets, and importers will pay higher prices and insurance premiums to offset risks taken by the supplier.

    “Countries with zero-tolerance policies will be perceived as risky export markets, and importers will pay higher prices and insurance premiums to offset risks taken by the supplier.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S4 (based).

    Interpretationreasoning
    § Conclusions · p. 20

    The approval of second-generation GE crops with improved output traits will further complicate the sourcing of non-GE feedstuffs.

    “Their approval will further complicate the sourcing of non-GE feedstuffs.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Interpretationcitation
    § The Future · p. 19

    The emergence of precise gene-editing technologies will further complicate the regulatory situation for GE crops and animals.

    “will further complicate this situation.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Kim and Kim, 2014

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation
    § The Future · p. 19

    The global hectarage of GE crops and the number of countries that raise them are expanding.

    “3) the expanding global hectarage of GE crops and the growing number of countries that raise them;”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Kalaitzandonakes et al. (2014) source

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Premisecitation
    § The Future · p. 19

    Regulatory expertise in many countries is nascent and inexperienced, and these countries will be called on to manage a large number of regulatory submissions for new GE crops in the future.

    “4) the nascent and inexperienced regulatory expertise in many countries that will be called on to manage a large number of regulatory submissions for new GE crops in the future.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites Kalaitzandonakes et al. (2014) source

      Not checked in the free run.

134 of 134
  • The paper relies on this without support.

    DNA and protein are normal components of the diet and are digested.

    “Because DNA and protein are normal components of the diet that are digested”
  • The paper relies on this without support.

    Globally, countries that are cultivating GE corn and soy are the major livestock feed exporters.

    “Globally, countries that are cultivating GE corn and soy are the major livestock feed exporters.”
  • The paper relies on this without support.

    Asynchronous regulatory approvals have resulted in trade disruptions.

    “Asynchronous regulatory approvals (i.e., cultivation approvals of GE varieties in exporting countries occurring before food and feed approvals in importing countries) have resulted in trade disruptions.”
  • The paper relies on this without support.

    Plant varieties developed through other processes of achieving genetic changes, such as radiation mutagenesis, go through no formal risk assessment before being placed on the market.

    “By contrast, plant varieties developed through other processes of achieving genetic changes (e.g., radiation mutagenesis) go through no formal risk assessment before being placed on the market.”
  • The paper relies on this without support.

    The United States and Australia/New Zealand explicitly do not require a 90-day subchronic rodent feeding study or actively discourage their conduct due to their negligible scientific value.

    “The United States and Australia/New Zealand explicitly do not require a 90-d subchronic rodent feeding study or actively discourage their conduct due to their negligible scientific value.”
  • The paper relies on this without support.

    GE proteins are digested in the gut and no intact GE protein has been found in the bloodstream.

    “especially given that GE proteins are digested in the gut and no intact GE protein has been found in the bloodstream.”
  • The paper relies on this without support.

    There are a large number of second-generation GE crops with altered output traits for improved livestock feed in the developmental and regulatory pipelines.

    “there are a large number of 'second generation' GE crops with altered output traits for improved livestock feed in the developmental and regulatory pipelines.”
  • The paper relies on this without support.

    In a typical U.S. broiler operation, chickens are fed for 42–49 d on diets composed of approximately 35% soybean meal and 65% corn grain.

    “in a typical U.S. broiler operation, chickens are fed for 42-49 d on diets that are composed of approximately 35% soybean meal and 65% corn grain”
  • The paper relies on this without support.

    The average U.S. dairy cow has a productive life of 5 yr with 3 conceptions, 3 gestations, and 3 lactations.

    “The average U.S. dairy cow has a productive life of 5 yr with 3 conceptions, 3 gestations, and 3 lactations.”
  • The paper relies on this without support.

    A typical U.S. dairy diet contains 50% corn silage, 20% corn grain, and 10% dehulled soybean meal.

    “A typical U.S. dairy diet contains 50% corn silage, 20% corn grain, and 10% dehulled soybean meal.”
  • The paper relies on this without support.

    Many cows receive large portions of their rations as ground corn grain, fuzzy cottonseed, or roasted full-fat soybeans.

    “Also, many cows receive large portions of their rations as ground corn grain, fuzzy cottonseed (no processing except for removal of the lint), or roasted full-fat soybeans.”
  • The paper relies on this without support.

    Other GE sources of animal feed include alfalfa hay, sugar beet pulp, corn distillers grains or other coproducts from corn processing, cottonseed meal, canola meal, and soy hulls.

    “Other GE sources of animal feed include alfalfa hay, sugar beet pulp, corn distillers grains or other coproducts from corn processing, cottonseed meal, canola meal, and soy hulls.”
  • The paper relies on this without support.

    A beef cow on the range might consume only some GE alfalfa hay, but her progeny entering the feedlot might be expected to consume a ration containing high quantities of GE feed during their 120 d in the feedlot before harvest.

    “A beef cow on the range might consume only some GE alfalfa hay, but her progeny entering the feedlot might be expected to consume a ration containing high quantities of GE feed during their 120 d in the feedlot before harvest.”
  • The authors state this as an assumption.

    If animal feed derived from GE crops had deleterious effects on animals consuming GE feed, then animal performance and health attributes in these large commercial livestock populations would have been negatively impacted.

    “It would be reasonable to hypothesize that if animal feed derived from GE crops had deleterious effects on animals consuming GE feed, then animal performance and health attributes in these large commercial livestock populations would have been negatively impacted.”
  • The paper relies on this without support.

    All animals arriving at USDA-inspected slaughter facilities undergo both antemortem and postmortem inspections to identify abnormalities.

    “All animals arriving at USDA-inspected slaughter facilities undergo both antemortem and postmortem inspections to identify abnormalities.”
  • The paper relies on this without support.

    Carcasses are condemned postmortem if there are visible lesions or tumors present on organs and carcasses.

    “Carcasses are condemned postmortem if there are visible lesions or tumors present on organs and carcasses.”
  • The paper relies on this without support.

    Animals and humans regularly ingest DNA and RNA as part of traditional diets without consequence.

    “It is important to note that animals and humans regularly ingest DNA and RNA as part of traditional diets without consequence.”
  • The paper relies on this without support.

    Approximately 9 billion broilers are processed annually in the United States.

    “approximately 9 billion broilers are processed annually in the United States”
  • The paper relies on this without support.

    Only Brazil currently requires mandatory labeling of products from animals that consume GE feed.

    “only Brazil currently re -quires mandatory labeling of products from animals that consume GE feed.”
  • The paper relies on this without support.

    In some countries, mandatory food labeling regulations target the presence of GE components in the finished product (e.g., Australia, New Zealand, and Japan), whereas in other countries, regulations target foods that use GE technology as a part of the production process (e.g., the EU, Brazil, and China).

    “In some countries, mandatory food labeling regulations target the presence of GE components in the finished product (e.g., Australia, New Zealand, and Japan), whereas in other countries, regulations target foods that use GE technology as a part of the production process (e.g., the EU, Brazil, and China).”
  • The authors state this as an assumption.

    The volume of traded soybeans required to be identity-preserved certified non-GE is segregated from supplies that may contain GE soybeans.

    “if it is as -sumed that this volume of traded soybeans is segregated from supplies that may contain GE soybeans”
  • The paper relies on this without support.

    Harvesting machinery and storage facilities are shared among different agricultural production systems.

    “realities of agricultural production systems where harvesting machinery and storage facilities are shared among different production systems”
22 of 22

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Several groups reviewing the evidence for health hazards of genetic modification have found no evidence for harms, but methods for such evaluation remain heterogeneous.

    “Several groups reviewing the evidence for health hazards of genetic modification have found no evidence for harms;130-134 however, methods for such evaluation remain heterogeneous.135-139”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

Each contradiction between two passages listed here was confirmed by an independent check.

  • GE feed crops are said to have been introduced in two different years

    Minor

    The paper repeatedly gives 1996 as the introduction year, but the description of Table 4 says 1986.

  • Table 7 cottonseed-meal percentage does not match its trade figures

    Minor

    Table 7 lists 0.63 million t as the share of cottonseed-meal trade that may contain GE material and 0.6 million t as total trade. The listed share is 105% of total trade, not the reported 45%.

    Reported 45 · recomputed 105

2 of 2

Cites

1 retracted

Flagged first, then by citations

12 of the 119 references couldn’t be matched to a known paper.

Research works printed but not linked: 5

  1. European Feed Manufacturers' Federation, 2013, XXVI FEFAC congress 2013, The feed chain in action.
  2. European Food Safety Authority, 2011, Opinion of the scientific committee/scientific panel. Statistical significance and biological relevance, EFSA J., 9, 2372
  3. International Life Sciences Institute, 2007, Best practices for the conduct of animal studies to evaluate crops genetically modified for output traits
  4. James, 2013, Global status of commercialized biotech/GM crops: 2013
  5. Velmirov, 2008, Biological effects of transgenic maize NK603xMON810 fed in long term reproduction studies in mice, Bundesministerium fur Gesundheit, Familie und Jugend.

Cited by

Sorted by citations

Authors
Van Eenennaam, A. L., & Young, A. E.
Affiliations
  • Department of Animal Science, University of California, Davis 95616
  • University of California, Davis (US)
Venue
Journal of Animal Science
Published
2014-10-01
Volume
92
Issue
10
Pages
4255-4278
ISSN
  • 0021-8812 (ISSN-L)
  • 1525-3163
OpenAlex
W2087980057
Cited by
154
References
119
Citations by year
2026: 6 · 2025: 7 · 2024: 6 · 2023: 10 · 2022: 16 · 2021: 3 · 2020: 18 · 2019: 11 · 2018: 10 · 2017: 31 · 2016: 17 · 2015: 18 · 2013: 1
FWCI
2.49
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Animal Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural safety and regulations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
Keywords
livestock performance, livestock health, genome editing, international regulatory harmonization, animal feed
MeSH terms
Animals, Animal Feed, Breeding, Edible Grain, Eggs, Female, Genetic Engineering, Meat, Milk, Pregnancy, Prevalence, DNA, Plant, Pregnancy Rate, Livestock

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-10-10.

Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-10-10.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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