The Feasibility, Acceptability, and Utility of Mantente REAL: the Culturally Adapted Version of keepin’ it REAL for Mexico
Abstract
A binational team of investigators culturally adapted, implemented, and tested the efficacy in Mexico of keepin' it REAL, a US-designed prevention intervention for youth. This article reports on the social validity of the adapted intervention by assessing its feasibility, acceptability, and utility, as perceived by participating middle school students, teachers/implementers, and school administrators. Middle schools (N = 36) were randomly assigned to (1) the culturally adapted version for Mexico (Mantente REAL), (2) the original intervention from the USA (keepin' it REAL) translated into Spanish, or (3) a control condition (treatment as usual). Adult and child feedback about the adapted and original versions of the intervention indicate that both are feasible to implement in the Mexican context. Implementation fidelity was equally high for both versions of the manualized intervention. Students, however, were more satisfied with the culturally adapted version than with the non-adapted version. They reported gaining more knowledge, finding it more acceptable, applicable, and authentic, and they reported discussing the program with their family and friends more often. The findings support the feasibility of engaging classroom teachers to implement manualized prevention programs in Mexico. These findings also advance prevention science by documenting the importance of cultural adaptation as a means to increase students' identification with and acceptability of efficacious school-based interventions. The article discusses the practice, policy, and future prevention research implications of the findings for Mexico and their potential generalizability to other middle- and lower-income countries.
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EBIs offer a cost-effective means to engage youth in preventive education.
“EBIs —defined as programs, practices, processes, policies, and guidelines with proven efficacy or effectiveness in a specific population and context (Rabin et al., 2008)—offer a cost-effective means to engage youth in preventive education (Marsiglia et al., 2022).”
From Exploring Cultural Adaptations: A Scoping Review on Adolescent Mental Health and Substance Use Prevention Programs (2025) · cites this paper as Marsiglia et al., 2022
Of the six cost-effectiveness studies, four were deemed cost-effective, one potentially cost-effective, and one not cost-effective.
“Out of these, four were deemed cost-effective (Marsiglia et al., 2022; Vargas-Martínez, 2023; Whitesell et al., 2019; Wimbish-Cirilo, 2016), one was potentially cost-effective (Tamí-Maury et al., 2019), and one was not cost-effective(Segrott et al., 2022).”
From Exploring Cultural Adaptations: A Scoping Review on Adolescent Mental Health and Substance Use Prevention Programs (2025) · cites this paper as Marsiglia et al., 2022
Many countries worldwide lack access to effective and culturally appropriate substance use prevention programs.
“Moreover, many countries worldwide lack access to effective and culturally appropriate substance use prevention programs (Marsiglia et al., 2022).”
From Exploring Cultural Adaptations: A Scoping Review on Adolescent Mental Health and Substance Use Prevention Programs (2025) · cites this paper as Marsiglia et al., 2022
Cites
Using thematic analysis in psychology
Braun, V., & Clarke, V. (2006) · Qualitative Research in Psychology · doi:10.1191/1478088706qp063oa · Cited by 194,414 · see citing works
Culturally adapted mental health intervention: a meta-analytic review
Griner, D., & Smith, T. B. (2006) · Psychotherapy: Theory, Research, Practice, Training · doi:10.1037/0033-3204.43.4.531 · Cited by 1,236 · see citing works
Guidance for conducting feasibility and pilot studies for implementation trials
Pearson, N., Naylor, P.-J., Ashe, M. C., Fernandez, M., Yoong, S. L., & Wolfenden, L. (2020) · Pilot and Feasibility Studies · doi:10.1186/s40814-020-00634-w · Cited by 475 · cited 1× · see citing works
“1 3 MREAL was successfully implemented in middle schools across Mexico and the present study analyzed its social validity across three validated constructs (Pearson et al., 2020; Weiner et al., 2017): (1) feasibility is the degree to which an intervention can be successfully implemented within a given setting.”
BackgroundInstrumentation issues in implementation science
Martinez, R. G., Lewis, C. C., & Weiner, B. J. (2014) · Implementation Science · doi:10.1186/s13012-014-0118-8 · Cited by 243 · see citing works
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Corpus-Espinosa, C., Mac Fadden, I., del Carmen Torrejón-Guirado, M., & Lima-Serrano, M. (2025) · Prevention Science · doi:10.1007/s11121-025-01779-x · Cited by 14 · see citing works
- Authors
- Marsiglia, F. F., Kulis, S. S., Cutrín, O., Medina-Mora, M. E., Real, T., Nuño-Gutiérrez, B. L., Corona, M. D., Mendoza-Meléndez, M. Á., Gresenz, K., & Alcala-Calvillo, D.
- Affiliations
- Arizona State University (US)
- Universidade de Santiago de Compostela (ES)
- Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz (MX)
- Universidad de Guadalajara (MX)
- Universidad Autónoma de Nuevo León (MX)
- Instituto Politécnico Nacional (MX)
- Corresponding author
- Marsiglia, Flavio F.
- ORCID
- Venue
- Prevention Science
- Published
- 2022-07-21
- Volume
- 23
- Issue
- 8
- Pages
- 1483-1494
- ISSN
- 1389-4986 (ISSN-L)
- 1573-6695
- OpenAlex
- W4286111551
- Cited by
- 7
- References
- 4
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2022: 1
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Prevention Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (R01DA038657)
- Topics
- Health Sciences › Health Professions › Speech and Hearing › School Health and Nursing Education
- Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- keepin' it REAL, cultural adaptation, school-based prevention intervention, adolescent substance use prevention, intervention feasibility, treatment acceptability, social validity, implementation fidelity, junior high school students, Spanish translation, teacher implementation
- MeSH terms
- Adolescent, Child, Feasibility Studies, Humans, Mexico, Schools, Students, Substance-Related Disorders
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