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Estimating the minimum important change in the 15D scores

Alanne, Soili, Roine, Risto P., Räsänen, Pirjo, Vainiola, Tarja, Sintonen, Harri·2015·Quality of Life Research

DOI 10.1007/s11136-014-0787-4

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Abstract

Purpose To facilitate the interpretation of empirical results produced by the 15D, a generic, preference-based instrument for measuring health-related quality of life (HRQoL), a subjective five-category global assessment scale (GAS) was used as an external anchor to determine the minimum important change (MIC) in the 15D scores.Methods Altogether 4,903 hospital patients representing sixteen disease entities and having the 15D score at baseline repeated the HRQoL assessment at 6 months after treatment and answered the question: compared to the situation before treatment, my overall health status is now (1) much better, (2) slightly better, (3) much the same, (4) slightly worse, (5) much worse. Regression analysis was used to estimate the MIC for improvement/deterioration, defined as the lower/upper limit of 99.9 % confidence interval of the regression coefficient, standardized for baseline HRQoL, for categories (2) and (4), respectively, and confirmed by ROC curve analysis.Results The limits or intervals for classifying the changes of 15D scores into GAS categories were >.035 for (1), .015-.035 for (2),>-.015 and<.015 for (3), -.035--.015 for (4) and <-.035 for (5). The lower/upper limits of ±.015 for categories (2) and (4) can be regarded as the generic MIC thresholds for improvement/deterioration, respectively.Conclusions The generic MICs for the change of 15D scores are ±.015. Follow-up studies using the 15D should report the mean change in the 15D score, its statistical significance, relationship to the MIC, and the distribution of the changes of the 15D scores into the five categories.

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“Gestational diabetes 11 (5) 10 (18) 10 (30) <0.”
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“Patients answer the questions concerning all dimensions by choosing a value from 1 (best) to 5 (worst situation) [19, 20].”
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Kask, G., Repo, J. P., Tukiainen, E. J., BLOMQVIST, C. P., & Barner-Rasmussen, I. (2021) · Annals of Surgical Oncology · doi:10.1245/s10434-021-09774-6 · Cited by 22
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Puranen, T. M., Hiltunen, K., Kautiainen, H., Suominen, M. H., Salminen, K., Mäntylä, P., Roitto, H., Pitkälä, K. H., & Saarela, R. K. T. (2023) · European Geriatric Medicine · doi:10.1007/s41999-023-00859-x · Cited by 22
“A minimum clinically important change/difference in the 15D score has been estimated to be ± 0.015 [19].”
BackgroundInfluential
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Heiskanen, J., Tolppanen, A., Roine, R. P., Hartikainen, J. E. K., Hippeläinen, M., Miettinen, H., & Martikainen, J. A. (2016) · European Heart Journal - Quality of Care and Clinical Outcomes · doi:10.1093/ehjqcco/qcw002 · Cited by 27
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“015 in the 15D score is considered clinically important because people can usually sense such a magnitude of change (14).”
BackgroundSelf-citation
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Purola, P. K. M., Nättinen, J. E., Parkkari, M., Ojamo, M., Koskinen, S. V. P., Rissanen, H. A., Sainio, P., & Uusitalo, H. M. T. (2021) · Acta Ophthalmologica · doi:10.1111/aos.14883 · Cited by 21
“A difference of ≥0.015 is considered to be clinically meaningful (Alanne et al. 2015).”
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Lehtomäki, K., Stedt, H., Österlund, E., Muhonen, T. T., Soveri, L., Halonen, P., Salminen, T. K., Kononen, J., Kallio, R. S., Ålgars, A., et al. (2022) · Cancers · doi:10.3390/cancers14071713 · Cited by 21
“035| was considered much better or worse [25].”
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“Figure 1 shows the distribution of patients into different categories of clinical importance according to the change in the 15D score (Alanne et al., 2015).”
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“035 to indicate a major improvement or deterioration (Alanne et al., 2015).”
BackgroundMethodInfluentialSelf-citation
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“sidered clinically important in the sense that a person on average can feel such a difference [17].”
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“027, indicating improvement in HR-QoL [21].”
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“015 in the total 15D score is considered clinically or practically important because people can usually sense such a magnitude of change.([18]) If patient did not answer all the”
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Health-Related Quality of Life of Patients with Hidradenitis Suppurativa Measured with the 15D Instrument and Comparison with the General Population and Patients with Psoriasis
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“015 in the 15D score between patient groups is considered minimally clinically important [21].”
BackgroundSelf-citation
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Self-citation
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“To facilitate the clinical interpretation of the 15D scores, Alanne et al. (2015) applied a subjective five-category global assessment scale (GAS) to estimate a minimum important change (MIC) in the 15D total score which they found to be ±0.015.”
BackgroundMethodInfluential
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“02 units as the minimum important change (MIC) for the 15D [50].”
Background
Long-term quality of life after surgery of head and neck cancer with microvascular reconstruction: a prospective study with 4.9-years follow-up
Kainulainen, S., Koivusalo, A., Roine, R. P., Wilkman, T. S. E., Sintonen, H., Törnwall, J., Thorén, H., & Lassus, P. (2019) · Oral and Maxillofacial Surgery · doi:10.1007/s10006-019-00806-w · Cited by 16
Self-citation
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Aro, K. L. S., Bäck, L. J. J., Loimu, V., Saarilahti, K., Rogers, S. N., Sintonen, H., Roine, R., & Mäkitie, A. A. (2015) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-015-3732-4 · Cited by 16
Self-citation
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“015 is clinically important.(17) The results obtained with the 15D were compared with those of the general population (n = 1,347) standardized for age and sex and obtained from the Helsinki University Hospital catchment area of the Finnish Health 2011 Survey.”
MethodSelf-citation
Patient features predicting long‐term survival and health‐related quality of life after radical surgery for non‐small cell lung cancer
Rauma, V., Salo, J., Sintonen, H., Räsänen, J. V., & Ilonen, I. (2016) · Thoracic Cancer · doi:10.1111/1759-7714.12333 · Cited by 15
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Rantasalo, M., Palanne, R. A., Lahtinen, K., Kairaluoma, P. M., Linko, R., Reponen, E., Helkamaa, T., Vakkuri, A., Olkkola, K. T., Madanat, R., et al. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-025546 · Cited by 14
No deterioration in health-related quality of life in patients with axial spondyloarthritis followed for 5 years in ordinary outpatient clinics in the biological treatment era
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Perceived Financial Satisfaction, Health Related Quality of Life and depressive Symptoms in Early Pregnancy
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“1 3 1 describing the best possible situation (no problems on any dimension) and 0 the worst (equivalent to being dead) (Sintonen 2001; Alanne et al. 2015).”
BackgroundSelf-citation
Patient characteristics in a return to work programme for common mental disorders: a cross-sectional study
Victor, M., Lau, B., & Ruud, T. (2016) · BMC Public Health · doi:10.1186/s12889-016-3431-0 · Cited by 13
“015 in the 15D score is considered clinically important [44].”
Background
Health-related quality of life after oncological resection and reconstruction of the chest wall
Salo, J., Repo, J. P., Roine, R. P., Sintonen, H., & Tukiainen, E. J. (2019) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2019.05.040 · Cited by 13
“The median (range, SD) time after primary surgery was 66 (16-241, 67) months.”
BackgroundSelf-citation

Authors: Alanne, S., Roine, R. P., Räsänen, P., Vainiola, T., & Sintonen, H.
Affiliations: Seinäjoen Keskussairaala (FI)
University of Eastern Finland (FI)
Hospital District of Helsinki and Uusimaa (FI)
University of Helsinki (FI)
Corresponding author: Sintonen, Harri
ORCID: Alanne, Soili
Roine, Risto P.
Räsänen, Pirjo
Sintonen, Harri
Venue: Quality of Life Research
Publisher: Springer Science and Business Media LLC
Published: 2014-08-22
Volume: 24
Issue: 3
Pages: 599-606
ISSN: 0962-9343 (ISSN-L)
1573-2649
DOI: 10.1007/s11136-014-0787-4
OpenAlex: W2023078845
Cited by: 231
References: 31
Citations by year: 2026: 8 · 2025: 17 · 2024: 17 · 2023: 19 · 2022: 18 · 2021: 38 · 2020: 16 · 2019: 26 · 2018: 16 · 2017: 20 · 2016: 23 · 2015: 11 · 2014: 1
FWCI: 45.59
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Quality of Life Research (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Economic and Environmental Valuation
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Medical Practices and Rehabilitation
Keywords: 15D, health-related quality of life, Global Assessment Scale, self-rated health, hospitalized patients
MeSH terms: Female, Finland, Follow-Up Studies, Health Status, Humans, Male, Middle Aged, Quality of Life, Surveys and Questionnaires, Research Design, ROC Curve, Models, Statistical

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Estimating the minimum important change in the 15D scores

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