CoChat
Sign Up
Cited by 80Health Systems, Economic Evaluations, Quality of LifeMusculoskeletal pain and rehabilitationPain Management and Opioid Use

The DOI matches its Crossref record; 52 of the 55 references it cites were found in a registry or an index.

Validation of EQ-5D and 15D in the assessment of health-related quality of life in chronic pain

Vartiainen, Pekka, Mäntyselkä, Pekka, Heiskanen, Tarja, Hagelberg, Nora, Mustola, Seppo, Forssell, Heli, Kautiainen, Hannu, Kalso, Eija·2017·Pain
DOI 10.1097/j.pain.0000000000000954
Open this paper in CoChat — free account

Abstract

Chronic pain has a significant impact on quality of life. Measurement of health-related quality of life (HRQoL) is essential in the assessment of pain management outcomes, but different instruments have produced varying results. We assessed the validity of 2 HRQoL instruments, EuroQol 5 dimensions questionnaire (EQ-5D) and 15-dimensional health-related quality of life measure (15D), in patients with challenging chronic pain. Three hundred ninety-one chronic noncancer pain patients referred to tertiary pain clinics completed EQ-5D, 15D, and a broad set of questionnaires mapping socioeconomic factors, self-rated health, pain intensity and interference, depression, pain acceptance, pain-related anxiety, and sleep. The 2 HRQoL instruments were compared with each other, and head-to-head comparisons were made with self-rated health and the symptom-specific questionnaires. 15D and EQ-5D showed moderate agreement (ρ = 0.66), but there were also considerable differences between the instruments. 15D correlated better with self-rated health than EQ-5D (ρ = −0.62 vs −0.45, P < 0.001). The EQ-5D appeared less sensitive than 15D especially in those patients with chronic pain who had a better health status. The principal component constructed from measures of pain intensity and interference, anxiety, pain acceptance, depression, and sleep had higher standardized beta coefficients with 15D than with EQ-5D ( P = 0.038). The principal component explained more variance in the 15D ( R 2 = 0.65) than in the EQ-5D ( R 2 = 0.43). The study identified differences in the pain-related variables between the EQ-5D and the 15D. In patients with chronic pain, both instruments are valid, but 15D appears somewhat more sensitive than EQ-5D.

Overview

Integrity signals

Registry

Crossref · 10.1097/j.pain.0000000000000954

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 55 references

Cited by

Sorted by citations

See all 80

Related

See all

Metadata

Authors
Vartiainen, P., Mäntyselkä, P., Heiskanen, T., Hagelberg, N., Mustola, S., Forssell, H., Kautiainen, H., & Kalso, E.
Affiliations
  • University of Helsinki (FI)
  • University of Eastern Finland (FI)
  • University of Turku (FI)
  • South Karelia Central Hospital (FI)
Corresponding author
Vartiainen, Pekka
ORCID
Venue
Pain
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2017-05-23
Volume
158
Issue
8
Pages
1577-1585
ISSN
  • 0304-3959 (ISSN-L)
  • 1872-6623
DOI
10.1097/j.pain.0000000000000954
OpenAlex
W2620532887
Cited by
80
References
55
Citations by year
2026: 2 · 2025: 9 · 2024: 8 · 2023: 9 · 2022: 8 · 2021: 22 · 2020: 7 · 2019: 10 · 2018: 2 · 2017: 2
FWCI
10.32
Type
journal article
Language
en
Open access
closed
Locations
  • Pain (publishedVersion)
  • PubMed (publishedVersion)
  • UEF eRepo (University of Eastern Finland) (acceptedVersion)
Topics
  • Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Keywords
chronic non-cancer pain, health-related quality of life, EQ-5D, 15D, instrument validation, self-rated health, pain-related anxiety, pain acceptance, depression, sleep, measurement sensitivity
MeSH terms
Adult, Anxiety, Female, Health Status, Humans, Male, Middle Aged, Psychometrics, Quality of Life, Surveys and Questionnaires, Socioeconomic Factors, Chronic Pain

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Validation of EQ-5D and 15D in the assessment of health-related quality of life in chronic pain. https://app.cochat.ai/papers/10.1097/j.pain.0000000000000954
The paper
Vartiainen, P., Mäntyselkä, P., Heiskanen, T., Hagelberg, N., Mustola, S., Forssell, H., Kautiainen, H., & Kalso, E. (2017). Validation of EQ-5D and 15D in the assessment of health-related quality of life in chronic pain. Pain. https://doi.org/10.1097/j.pain.0000000000000954