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Cited by 74Obstructive Sleep Apnea ResearchInflammatory Biomarkers in Disease PrognosisApelin-related biomedical research

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Platelet–lymphocyte ratio is an independent predictor for cardiovascular disease in obstructive sleep apnea syndrome

Koseoglu, Handan Inonu, Altunkas, Fatih, Kanbay, Asiye, Doruk, Sibel, Etikan, Ilker, Demir, Osman·2015·Journal of Thrombosis and Thrombolysis
DOI 10.1007/s11239-014-1103-4
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Abstract

There is a strong relationship between obstructive sleep apnea syndrome (OSAS) and cardiovascular disease (CVD). Chronic intermittent hypoxia, inflammation, oxidative stress, and endothelial dysfunction may constitute etiologic mechanisms, linking OSAS to CVD. Inflammation play an important role in the development of CVD. Platelet-lymphocyte ratio (PLR) is a new biomarker showing inflammation. No previous study has ever investigated the association between PLR, CVD and OSAS severity in patients with OSAS. This study was designed to investigate the association between PLR and CVD in patients with OSAS, and relationship between severity of OSAS, polysomnographic parameters and PLR. This was a cohort study in which patients who had undergone a full night polysomnoraphy for diagnosis of OSA were recruited. Patients were divided according to their apnea-hypopnea index (AHI) scores into OSAS negative (Group 1: AHI < 5), mild (Group 2: AHI, 5-15), moderate (Group 3:AHI,15-30), and severe OSAS (Group 4: AHI > 30) groups. The presence of heart failure, coronary artery disease or arrhythmia was defined as CVD. A total of 424 patients were included in this study. There were 57, 93, 82, and 192 patients in Groups 1, 2, 3, and 4, respectively. PLR were significantly different between groups (Group 1: 87.38; Group 2: 95.07; Group 3: 97.01, Group 4: 126.9, P < 0.05). PLR were significantly correlated with AHI, oxygen desaturation index, average and minimum O2 saturation values (P < 0.05). Values of PLR were significantly higher in patients with CVD compared with those without. Multiple regression analysis demonstrated that PLR is an independent predictor of CVD. PLR cut-off value for demonstrating the presence of CVD is higher than 108.56. In the light oh findings, PLR is strongly associated with the severity of OSAS and cardiovascular disease in OSAS patients. PLR might be used as a biomarker to predict CVD in OSAS patients.

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Crossref · 10.1007/s11239-014-1103-4

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Metadata

Authors
Koseoglu, H. I., Altunkas, F., Kanbay, A., Doruk, S., Etikan, I., & Demir, O.
Affiliations
  • Istanbul Medeniyet University (TR)
  • Tokat Gaziosmanpaşa Üniversitesi (TR)
ORCID
Venue
Journal of Thrombosis and Thrombolysis
Publisher
Springer Science and Business Media LLC
Published
2014-07-08
Volume
39
Issue
2
Pages
179-185
ISSN
  • 0929-5305 (ISSN-L)
  • 1573-742X
DOI
10.1007/s11239-014-1103-4
OpenAlex
W2021366895
Cited by
74
References
43
Citations by year
2026: 1 · 2025: 6 · 2024: 9 · 2023: 8 · 2022: 3 · 2021: 2 · 2020: 6 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 7 · 2015: 8 · 2014: 2
FWCI
5.32
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Thrombosis and Thrombolysis (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
  • Health Sciences › Medicine › Pharmacology (medical) › Apelin-related biomedical research
Keywords
platelet-to-lymphocyte ratio, obstructive sleep apnea, cardiovascular disease, inflammatory markers, OSA severity, apnea-hypopnea index, oxygen desaturation index, heart failure, coronary artery disease, cardiac arrhythmias, intermittent hypoxia
MeSH terms
Adult, Hypoxia, Cardiovascular Diseases, Female, Humans, Inflammation, Male, Middle Aged, Platelet Count, Predictive Value of Tests, Prognosis, Severity of Illness Index, Statistics as Topic, Turkey, Cohort Studies, Oxidative Stress, Lymphocyte Count, Sleep Apnea, Obstructive

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