The DOI matches its Crossref record; 154 of the 154 references it cites were found in a registry or an index.
P2 receptors in cardiovascular regulation and disease
Open accessAbstract
The role of ATP as an extracellular signalling molecule is now well established and evidence is accumulating that ATP and other nucleotides (ADP, UTP and UDP) play important roles in cardiovascular physiology and pathophysiology, acting via P2X (ion channel) and P2Y (G protein-coupled) receptors. In this article we consider the dual role of ATP in regulation of vascular tone, released as a cotransmitter from sympathetic nerves or released in the vascular lumen in response to changes in blood flow and hypoxia. Further, purinergic long-term trophic and inflammatory signalling is described in cell proliferation, differentiation, migration and death in angiogenesis, vascular remodelling, restenosis and atherosclerosis. The effects on haemostasis and cardiac regulation is reviewed. The involvement of ATP in vascular diseases such as thrombosis, hypertension and diabetes will also be discussed, as well as various heart conditions. The purinergic system may be of similar importance as the sympathetic and renin-angiotensin-aldosterone systems in cardiovascular regulation and pathophysiology. The extracellular nucleotides and their cardiovascular P2 receptors are now entering the phase of clinical development.
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Cites
Inflammation, Atherosclerosis, and Coronary Artery Disease
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Receptors for Purines and Pyrimidines
Burnstock, G., & Verkhratsky, A. (2012) · Purinergic Signalling and the Nervous System · doi:10.1007/978-3-642-28863-0_5 · Cited by 3,958
Self-citationMehta, S. R., Yusuf, S., Peters, R. J., Bertrand, M. E., Lewis, B. S., Natarajan, M. K., Malmberg, K., Rupprecht, H.-J., Zhao, F., Chrolavicius, S., et al. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05701-4 · Cited by 2,809
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Receptors for Purines and Pyrimidines
Ralevic, V., & Burnstock, G. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01373-5 · Cited by 2,005
Self-citationBurnstock, G. (1972) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06930-3 · Cited by 1,852
Self-citationNitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807
Extracellular ATP: effects, sources and fate
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Cited by
Purinergic Signalling: Therapeutic Developments
Burnstock, G. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00661 · Cited by 398
Self-citationAutonomic Neurotransmission: 60 Years Since Sir Henry Dale
Burnstock, G. (2009) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.052808.102215 · Cited by 137
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Metadata
- Authors
- Erlinge, D., & Burnstock, G.
- Venue
- Purinergic Signalling
- Published
- 2007-09-21
- Volume
- 4
- Issue
- 1
- Pages
- 1-20
- ISSN
- 1573-9538 (ISSN-L)
- 1573-9546
- OpenAlex
- W2162008357
- Cited by
- 344
- References
- 154
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
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