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Receptors for Purines and Pyrimidines
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Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547
Self-citationFredriksson, R., Lagerström, M. C., Lundin, L.-G., & Schiöth, H. B. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.6.1256 · Cited by 2,941
Molecular Physiology of P2X Receptors
North, R. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00015.2002 · Cited by 2,919
DEVELOPMENT OF THE VERTEBRATE NEUROMUSCULAR JUNCTION
Sanes, J. R., & Lichtman, J. W. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.389 · Cited by 1,532
Adenosine Receptors as Therapeutic Targets
Jacobson, K. A., & Gao, Z.-G. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1983 · Cited by 1,431
Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
He, W., Miao, F. J.-P., Lin, D. C.-H., Schwandner, R. T., Wang, Z., Gao, J., Chen, J.-L., Tian, H., & Ling, L. (2004) · Nature · doi:10.1038/nature02488 · Cited by 909
Chen, Y., Wu, H., Wang, S., Koito, H., Li, J., Ye, F., Hoang, J., Escobar, S. S., Gow, A., Arnett, H. A., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2410 · Cited by 346
Lucae, S., Salyakina, D., Barden, N., Harvey, M., Gagné, B., Labbé, M., Binder, E. B., Uhr, M., Paez-Pereda, M., Sillaber, I., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl166 · Cited by 261
Johansson, B., Ahlberg, S., van der Ploeg, I., Brené, S., Lindefors, N., Persson, H., & Fredholm, B. B. (1993) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/bf00165391 · Cited by 144
Lai, H.-L., Yang, T.-H., Messing, R. O., Ching, Y.-H., Lin, S.-C., & Chern, Y. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.8.4970 · Cited by 129
Research works printed but not linked: 946
- Abbracchio MP, Verderio C (2006) Pathophysiological roles of P2 receptors in glial cells. Novartis Found Symp 276:91–103 discussion 103–112, 275–181 · DOI
- Abbracchio MP, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Miras-Portugal MT, King BF, Gachet C, Jacobson KA, Weisman GA, Burnstock G (2003) Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family. Trends Pharmacol Sci 24:52–55 · DOI · Paper page
- Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Knight GE, Fumagalli M, Gachet C, Jacobson KA, Weisman GA (2006) International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev 58:281–341 · DOI · Paper page
- Able SL, Fish RL, Bye H, Booth L, Logan YR, Nathaniel C, Hayter P, Katugampola SD (2011) Receptor localization, native tissue binding and ex vivo occupancy for centrally penetrant P2X7 antagonists in the rat. Br J Pharmacol 162:405–414 · DOI
- Acuna-Castillo C, Morales B, Huidobro-Toro JP (2000) Zinc and copper modulate differentially the P2X4 receptor. J Neurochem 74:1529–1537 · DOI
- Adinolfi E, Cirillo M, Woltersdorf R, Falzoni S, Chiozzi P, Pellegatti P, Callegari MG, Sandona D, Markwardt F, Schmalzing G, Di Virgilio F (2010) Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor. FASEB J 24:3393–3404 · DOI · Paper page
- Adriouch S, Scheuplein F, Bahring R, Seman M, Boyer O, Koch-Nolte F, Haag F (2009) Characterisation of the R276A gain-of-function mutation in the ectodomain of murine P2X7. Purinergic Signal 5:151–161 · DOI
- Agca C, Seye C, Kashuba Benson CM, Rikka S, Chan AW, Weisman GA, Agca Y (2009) Development of a novel transgenic rat overexpressing the P2Y2 nucleotide receptor using a lentiviral vector. J Vasc Res 46:447–458 · DOI
- Akbar GK, Dasari VR, Webb TE, Ayyanathan K, Pillarisetti K, Sandhu AK, Athwal RS, Daniel JL, Ashby B, Barnard EA, Kunapuli SP (1996) Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells. J Biol Chem 271:18363–18367 · DOI
- Allsopp RC, Lalo U, Evans RJ (2010) Lipid raft association and cholesterol sensitivity of P2X1–4 receptors for ATP: chimeras and point mutants identify intracellular amino-terminal residues involved in lipid regulation of P2X1 receptors. J Biol Chem 285:32770–32777 · DOI
- Alzola E, Perez-Etxebarria A, Kabre E, Fogarty DJ, Metioui M, Chaib N, Macarulla JM, Matute C, Dehaye JP, Marino A (1998) Activation by P2X7 agonists of two phospholipases A2 (PLA2) in ductal cells of rat submandibular gland. Coupling of the calcium-independent PLA2 with kallikrein secretion. J Biol Chem 273:30208–30217 · DOI
- Andre P, Delaney SM, LaRocca T, Vincent D, DeGuzman F, Jurek M, Koller B, Phillips DR, Conley PB (2003) P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries. J Clin Invest 112:398–406 · DOI · Paper page
- Andreev J, Galisteo ML, Kranenburg O, Logan SK, Chiu ES, Okigaki M, Cary LA, Moolenaar WH, Schlessinger J (2001) Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade. J Biol Chem 276:20130–20135 · DOI · Paper page
- Antonio L, Stewart A, Xu X, Varanda W, Murrell-Lagnado R, Edwardson J (2011) P2X4 receptors interact with both P2X2 and P2X7 receptors in the form of homotrimers. Br J Pharmacol 163:1069–1077 · DOI
- Asatryan L, Popova M, Woodward JJ, King BF, Alkana RL, Davies DL (2008) Roles of ectodomain and transmembrane regions in ethanol and agonist action in purinergic P2X2 and P2X3 receptors. Neuropharmacology 55:835–843 · DOI
- Asatryan L, Popova M, Perkins D, Trudell JR, Alkana RL, Davies DL (2011) Ivermectin antagonizes ethanol inhibition in purinergic P2X4 receptors. J Pharmacol Exp Ther 334:720–728 · DOI
- Aschrafi A, Sadtler S, Niculescu C, Rettinger J, Schmalzing G (2004) Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes. J Mol Biol 342:333–343 · DOI
- Ase AR, Raouf R, Belanger D, Hamel E, Seguela P (2005) Potentiation of P2X1 ATP-gated currents by 5-hydroxytryptamine 2A receptors involves diacylglycerol-dependent kinases and intracellular calcium. J Pharmacol Exp Ther 315:144–154 · doi:10.1124/jpet.105.089045
- Ashida N, Ueyama T, Rikitake K, Shirai Y, Eto M, Kondoh T, Kohmura E, Saito N (2008) Ca2+ oscillation induced by P2Y2 receptor activation and its regulation by a neuron-specific subtype of PKC (γPKC). Neurosci Lett 446:123–128 · DOI
- Auchampach JA, Jin X, Wan TC, Caughey GH, Linden J (1997) Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor. Mol Pharmacol 52:846–860 · DOI · Paper page
- Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP (1996) Cloning and chromosomal localization of the human P2Y1 purinoceptor. Biochem Biophys Res Commun 218:783–788 · DOI
- Bagchi S, Liao Z, Gonzalez FA, Chorna NE, Seye CI, Weisman GA, Erb L (2005) The P2Y2 nucleotide receptor interacts with alphav integrins to activate Go and induce cell migration. J Biol Chem 280:39050–39057 · DOI
- Bailey MA, Turner CM, Hus-Citharel A, Marchetti J, Imbert-Teboul M, Milner P, Burnstock G, Unwin RJ (2004) P2Y receptors present in the native and isolated rat glomerulus. Nephron Physiol 96:79–90 · doi:10.1159/000076753
- Ballini E, Virginio C, Medhurst S, Summerfield S, Aldegheri L, Buson A, Carignani C, Chen Y, Giacometti A, Lago I, Powell A, Jarolimek W (2011) Characterization of three diaminopyrimidines as potent and selective antagonists of P2X3 and P2X2/3 receptors with in vivo efficacy in a pain model. Br J Pharmacol 163:1315–1325 · DOI
- Balsinde J, Winstead MV, Dennis EA (2002) Phospholipase A2 regulation of arachidonic acid mobilization. FEBS Lett 531:2–6 · DOI · Paper page
- Baltensperger K, Porzig H (1997) The P2U purinoceptor obligatorily engages the heterotrimeric G protein G16 to mobilize intracellular Ca2+ in human erythroleukemia cells. J Biol Chem 272:10151–10159 · DOI
- Banfi C, Ferrario S, De Vincenti O, Ceruti S, Fumagalli M, Mazzola A, D’ Ambrosi N, Volonte C, Fratto P, Vitali E, Burnstock G, Beltrami E, Parolari A, Polvani G, Biglioli P, Tremoli E, Abbracchio MP (2005) P2 receptors in human heart: upregulation of P2X6 in patients undergoing heart transplantation, interaction with TNFα and potential role in myocardial cell death. J Mol Cell Cardiol 39:929–939 · DOI
- Baqi Y, Hausmann R, Rosefort C, Rettinger J, Schmalzing G, Muller CE (2011) Discovery of Potent Competitive Antagonists and Positive Modulators of the P2X2 Receptor. J Med Chem 54:817–830 · doi:10.1021/jm1012193
- Bar I, Guns PJ, Metallo J, Cammarata D, Wilkin F, Boeynams JM, Bult H, Robaye B (2008) Knockout mice reveal a role for P2Y6 receptor in macrophages, endothelial cells, and vascular smooth muscle cells. Mol Pharmacol 74:777–784 · DOI
- Baraldi PG, del Carmen Nunez M, Morelli A, Falzoni S, Di Virgilio F, Romagnoli R (2003) Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor. J Med Chem 46:1318–1329 · DOI
- Barden N, Harvey M, Gagne B, Shink E, Tremblay M, Raymond C, Labbe M, Villeneuve A, Rochette D, Bordeleau L, Stadler H, Holsboer F, Muller-Myhsok B (2006) Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder. Am J Med Genet B Neuropsychiatr Genet 141B:374–382 · DOI
- Barnard EA, Simon J (2001) An elusive receptor is finally caught: P2Y12, an important drug target in platelets. Trends Pharmacol Sci 22:388–391 · DOI
- Barrera NP, Ormond SJ, Henderson RM, Murrell-Lagnado RD, Edwardson JM (2005) Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize. J Biol Chem 280:10759–10765 · DOI · Paper page
- Baurand A, Raboisson P, Freund M, Leon C, Cazenave JP, Bourguignon JJ, Gachet C (2001) Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist. Eur J Pharmacol 412:213–221 · doi:10.1016/s0014-2999(01)00733-6
- Bean BP (1990) ATP-activated channels in rat and bullfrog sensory neurons: concentration dependence and kinetics. J Neurosci 10:1–10 · DOI · Paper page
- Belous A, Wakata A, Knox CD, Nicoud IB, Pierce J, Anderson CD, Pinson CW, Chari RS (2004) Mitochondrial P2Y-Like receptors link cytosolic adenosine nucleotides to mitochondrial calcium uptake. J Cell Biochem 92:1062–1073 · DOI
- Belous AE, Jones CM, Wakata A, Knox CD, Nicoud IB, Pierce J, Chari RS (2006) Mitochondrial calcium transport is regulated by P2Y1- and P2Y2-like mitochondrial receptors. J Cell Biochem 99:1165–1174 · DOI
- Benham CD, Tsien RW (1987) A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle. Nature 328:275–278 · DOI · Paper page
- Benned-Jensen T, Rosenkilde MM (2010) Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants. Br J Pharmacol 159:1092–1105 · DOI
- Bernier LP, Ase AR, Chevallier S, Blais D, Zhao Q, Boue-Grabot E, Logothetis D, Seguela P (2008) Phosphoinositides regulate P2X4 ATP-gated channels through direct interactions. J Neurosci 28:12938–12945 · DOI
- Berti-Mattera LN, Wilkins PL, Madhun Z, Suchovsky D (1996) P2-purigenic receptors regulate phospholipase C and adenylate cyclase activities in immortalized Schwann cells. Biochem J 314(Pt 2):555–561 · doi:10.1042/bj3140555
- Besada P, Shin DH, Costanzi S, Ko H, Mathe C, Gagneron J, Gosselin G, Maddileti S, Harden TK, Jacobson KA (2006) Structure-activity relationships of uridine 5′-diphosphate analogues at the human P2Y6 receptor. J Med Chem 49:5532–5543 · doi:10.1021/jm060485n
- Bianchi BR, Lynch KJ, Touma E, Niforatos W, Burgard EC, Alexander KM, Park HS, Yu H, Metzger R, Kowaluk E, Jarvis MF, van Biesen T (1999) Pharmacological characterization of recombinant human and rat P2X receptor subtypes. Eur J Pharmacol 376:127–138 · DOI · Paper page
- Bianco F, Fumagalli M, Pravettoni E, D′Ambrosi N, Volonte C, Matteoli M, Abbracchio MP, Verderio C (2005) Pathophysiological roles of extracellular nucleotides in glial cells: differential expression of purinergic receptors in resting and activated microglia. Brain Res Brain Res Rev 48:144–156 · DOI
- Bianco F, Ceruti S, Colombo A, Fumagalli M, Ferrari D, Pizzirani C, Matteoli M, Di Virgilio F, Abbracchio MP, Verderio C (2006) A role for P2X7 in microglial proliferation. J Neurochem 99:745–758 · DOI
- Blasius R, Weber RG, Lichter P, Ogilvie A (1998) A novel orphan G protein-coupled receptor primarily expressed in the brain is localized on human chromosomal band 2q21. J Neurochem 70:1357–1365 · doi:10.1046/j.1471-4159.1998.70041357.x
- Bo X, Zhang Y, Nassar M, Burnstock G, Schoepfer R (1995) A P2X purinoceptor cDNA conferring a novel pharmacological profile. FEBS Lett 375:129–133 · DOI · Paper page
- Bo X, Schoepfer R, Burnstock G (2000) Molecular cloning and characterization of a novel ATP P2X receptor subtype from embryonic chick skeletal muscle. J Biol Chem 275:14401–14407 · DOI
- Bo X, Jiang LH, Wilson HL, Kim M, Burnstock G, Surprenant A, North RA (2003) Pharmacological and biophysical properties of the human P2X5 receptor. Mol Pharmacol 63:1407–1416 · DOI
- Boarder M, Webb TE (2001) P2Y receptors structure and function. In: Abbracchio MP, Williams M (eds) Purinergic and pyrimidinergic signalling. Handbook of experimental pharmacology, vol 151/I, Springer, Heidelberg, pp 65–88 · doi:10.1007/978-3-662-09604-8_4
- Bodor ET, Waldo GL, Hooks SB, Corbitt J, Boyer JL, Harden TK (2003) Purification and functional reconstitution of the human P2Y12 receptor. Mol Pharmacol 64:1210–1216 · DOI
- Boeynaems JM, Wilkin F, Marteau F, Duhant X, Savi P, Gonzalez NS, Robaye B, Communi D (2003) P2Y receptors: new subtypes, new functions. Drug Devel Res 59:30–35 · DOI
- Bogdanov YD, Dale L, King BF, Whittock N, Burnstock G (1997) Early expression of a novel nucleotide receptor in the neural plate of Xenopus embryos. J Biol Chem 272:12583–12590 · DOI
- Bogdanov Y, Rubino A, Burnstock G (1998a) Characterisation of subtypes of the P2X and P2Y families of ATP receptors in the foetal human heart. Life Sci 62:697–703 · doi:10.1016/s0024-3205(97)01168-5
- Bogdanov YD, Wildman SS, Clements MP, King BF, Burnstock G (1998b) Molecular cloning and characterization of rat P2Y4 nucleotide receptor. Br J Pharmacol 124:428–430 · DOI · Paper page
- Boison D (2008) Adenosine as a neuromodulator in neurological diseases. Curr Opin Pharmacol 8:2–7 · DOI
- Boldt W, Klapperstuck M, Buttner C, Sadtler S, Schmalzing G, Markwardt F (2003) Glu496Ala polymorphism of human P2X7 receptor does not affect its electrophysiological phenotype. Am J Physiol Cell Physiol 284:C749–C756 · DOI
- Bolego C, Pinna C, Abbracchio MP, Cattabeni F, Puglisi L (1995) The biphasic response of rat vesical smooth muscle to ATP. Br J Pharmacol 114:1557–1562 · doi:10.1111/j.1476-5381.1995.tb14939.x
- Bongartz EV, Rettinger J, Hausmann R (2011) Aminoglycoside block of P2X2 receptors heterologously expressed in Xenopus laevis oocytes. Purinergic Signal 6:393–403 · doi:10.1007/s11302-010-9204-9
- Boue-Grabot E, Archambault V, Seguela P (2000) A protein kinase C site highly conserved in P2X subunits controls the desensitization kinetics of P2X2 ATP-gated channels. J Biol Chem 275:10190–10195 · DOI · Paper page
- Bouvier M (2001) Oligomerization of G-protein-coupled transmitter receptors. Nat Rev Neurosci 2:274–286 · DOI · Paper page
- Bowler WB, Birch MA, Gallagher JA, Bilbe G (1995) Identification and cloning of human P2U purinoceptor present in osteoclastoma, bone, and osteoblasts. J Bone Miner Res 10:1137–1145 · doi:10.1002/jbmr.5650100720
- Bowser DN, Khakh BS (2004) ATP excites interneurons and astrocytes to increase synaptic inhibition in neuronal networks. J Neurosci 24:8606–8620 · DOI
- Boyer JL, Romero-Avila T, Schachter JB, Harden TK (1996a) Identification of competitive antagonists of the P2Y1 receptor. Mol Pharmacol 50:1323–1329
- Boyer JL, Siddiqi S, Fischer B, Romero-Avila T, Jacobson KA, Harden TK (1996b) Identification of potent P2Y-purinoceptor agonists that are derivatives of adenosine 5′-monophosphate. Br J Pharmacol 118:1959–1964 · doi:10.1111/j.1476-5381.1996.tb15630.x
- Boyer JL, Mohanram A, Camaioni E, Jacobson KA, Harden TK (1998) Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2′-deoxyadenosine 3′,5′-bisphosphate. Br J Pharmacol 124:1–3 · DOI · Paper page
- Boyer JL, Delaney SM, Villanueva D, Harden TK (2000) A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is nonselectively activated by all nucleoside triphosphates. Mol Pharmacol 57:805–810 · doi:10.1124/mol.57.4.805
- Boyer JL, Adams M, Ravi RG, Jacobson KA, Harden TK (2002) 2-Chloro N(6)-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphate is a selective high affinity P2Y1 receptor antagonist. Br J Pharmacol 135:2004–2010 · DOI
- Bradley HJ, Baldwin JM, Goli GR, Johnson B, Zou J, Sivaprasadarao A, Baldwin SA, Jiang LH (2011) Residues 155 and 348 contribute to the determination of P2X7 receptor function via distinct mechanisms revealed by single-nucleotide polymorphisms. J Biol Chem 286:8176–8187 · DOI
- Brake AJ, Wagenbach MJ, Julius D (1994) New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature 371:519–523 · DOI · Paper page
- Brambilla R, Burnstock G, Bonazzi A, Ceruti S, Cattabeni F, Abbracchio MP (1999) Cyclo-oxygenase-2 mediates P2Y receptor-induced reactive astrogliosis. Br J Pharmacol 126:563–567 · DOI
- Brambilla R, Ceruti S, Malorni W, Cattabeni F, Abbracchio MP (2000) A novel gliotic P2 receptor mediating cyclooxygenase-2 induction in rat and human astrocytes. J Auton Nerv Syst 81:3–9 · doi:10.1016/s0165-1838(00)00152-1
- Brambilla R, Neary JT, Cattabeni F, Cottini L, D’Ippolito G, Schiller PC, Abbracchio MP (2002) Induction of COX-2 and reactive gliosis by P2Y receptors in rat cortical astrocytes is dependent on ERK1/2 but independent of calcium signalling. J Neurochem 83:1285–1296 · DOI
- Brambilla R, Neary JT, Fumagalli M, Cottini L, Cattabeni F, Schiller PR, Abbracchio MP (2003) P2Y receptors in brain astroglial cells: identification of a gliotic P2Y receptor coupled to activation of a calcium-independent Ras/ERK1/2 pathway. Drug Dev Res 59:161–170 · doi:10.1002/ddr.10217
- Brandle U, Spielmanns P, Osteroth R, Sim J, Surprenant A, Buell G, Ruppersberg JP, Plinkert PK, Zenner HP, Glowatzki E (1997) Desensitization of the P2X2 receptor controlled by alternative splicing. FEBS Lett 404:294–298 · DOI · Paper page
- Braun K, Rettinger J, Ganso M, Kassack M, Hildebrandt C, Ullmann H, Nickel P, Schmalzing G, Lambrecht G (2001) NF449: a subnanomolar potency antagonist at recombinant rat P2X1 receptors. Naunyn Schmiedebergs Arch Pharmacol 364:285–290 · DOI
- Briddon SJ, Gandia J, Amaral OB, Ferre S, Lluis C, Franco R, Hill SJ, Ciruela F (2008) Plasma membrane diffusion of G protein-coupled receptor oligomers. Biochim Biophys Acta 1783:2262–2268 · DOI
- Brink C, Dahlen SE, Drazen J, Evans JF, Hay DW, Nicosia S, Serhan CN, Shimizu T, Yokomizo T (2003) International union of pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors. Pharmacol Rev 55:195–227 · DOI · Paper page
- Brinson AE, Harden TK (2001) Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor. J Biol Chem 276:11939–11948 · doi:10.1074/jbc.m009909200
- Broom DC, Matson DJ, Bradshaw E, Buck ME, Meade R, Coombs S, Matchett M, Ford KK, Yu W, Yuan J, Sun SH, Ochoa R, Krause JE, Wustrow DJ, Cortright DN (2008) Characterization of N-(adamantan-1-ylmethyl)-5-[(3R-amino-pyrrolidin-1-yl)methyl]-2-chloro-ben zamide, a P2X7 antagonist in animal models of pain and inflammation. J Pharmacol Exp Ther 327:620–633 · DOI
- Brotherton-Pleiss CE, Dillon MP, Ford AP, Gever JR, Carter DS, Gleason SK, Lin CJ, Moore AG, Thompson AW, Villa M, Zhai Y (2010) Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist. Bioorg Med Chem Lett 20:1031–1036 · doi:10.1016/j.bmcl.2009.12.044
- Brown J, Brown CA (2002) Evaluation of reactive blue 2 derivatives as selective antagonists for P2Y receptors. Vascul Pharmacol 39:309–315 · doi:10.1016/s1537-1891(03)00030-2
- Brown DA, Yule DI (2007) Protein kinase C regulation of P2X3 receptors is unlikely to involve direct receptor phosphorylation. Biochim Biophys Acta 1773:166–175 · doi:10.1016/j.bbamcr.2006.09.020
- Brown DA, Filippov AK, Barnard EA (2000a) Inhibition of potassium and calcium currents in neurones by molecularly-defined P2Y receptors. J Auton Nerv Syst 81:31–36 · DOI
- Brown SG, King BF, Kim YC, Burnstock G, Jacobson KA (2000b) Activity of novel adenine nucleotide derivatives as agonists and antagonists at recombinant rat P2X receptors. Drug Dev Res 49:253–259 · doi:10.1002/1098-2299(200004)49:4<253::aid-ddr4>3.0.co;2-1
- Brown SG, Townsend-Nicholson A, Jacobson KA, Burnstock G, King BF (2002) Heteromultimeric P2X1/2 receptors show a novel sensitivity to extracellular pH. J Pharmacol Exp Ther 300:673–680 · DOI
- Browne LE, Jiang LH, North RA (2010) New structure enlivens interest in P2X receptors. Trends Pharmacol Sci 31:229–237 · DOI
- Brunschweiger A, Muller CE (2006) P2 receptors activated by uracil nucleotides–an update. Curr Med Chem 13:289–312 · doi:10.2174/092986706775476052
- Buell G, Lewis C, Collo G, North RA, Surprenant A (1996a) An antagonist-insensitive P2X receptor expressed in epithelia and brain. EMBO J 15:55–62 · DOI · Paper page
- Buell G, Michel AD, Lewis C, Collo G, Humphrey PP, Surprenant A (1996b) P2X1 receptor activation in HL60 cells. Blood 87:2659–2664 · DOI
- Buonanno A, Fischbach GD (2001) Neuregulin and ErbB receptor signaling pathways in the nervous system. Curr Opin Neurobiol 11:287–296 · DOI · Paper page
- Burgard EC, Niforatos W, van Biesen T, Lynch KJ, Kage KL, Touma E, Kowaluk EA, Jarvis MF (2000) Competitive antagonism of recombinant P2X2/3 receptors by 2′, 3′-O-(2,4,6-trinitrophenyl) adenosine 5′-triphosphate (TNP-ATP). Mol Pharmacol 58:1502–1510 · DOI
- Burnstock G (1978) A basis for distinguishing two types of purinergic receptor. In: Bolis L, Straub RW (eds) Cell membrane receptors for drugs and hormones. Raven Press, New York
- Burnstock G (1980) Purinergic nerves and receptors. Prog Biochem Pharmacol 16:141–154
- Burnstock G (2000) P2X receptors in sensory neurones. Br J Anaesth 84:476–488 · DOI · Paper page
- Burnstock G (2003) Introduction: ATP and its metabolites as potent extracellular agonists. In: Schwiebert EM (ed) Current topics in membranes, vol 54. Purinergic receptors and signalling. Academic Press, San Diego, pp 1–27 · doi:10.1016/s1063-5823(03)01001-9
- Burnstock G (2007) Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev 87:659–797 · DOI · Paper page
- Burnstock G (2009a) Purinergic receptors and pain. Curr Pharm Des 15:1717–1735 · DOI · Paper page
- Burnstock G (2009b) Purinergic regulation of vascular tone and remodelling. Auton Autacoid Pharmacol 29:63–72 · DOI
- Burnstock G, Kennedy C (1985) Is there a basis for distinguishing two types of P2-purinoceptor? Gen Pharmacol 16:433–440 · DOI · Paper page
- Burnstock G, Kennedy C (2011) P2X receptors in health and disease. Adv Pharmacol 61:333–372 · DOI · Paper page
- Burnstock G, Knight GE (2004) Cellular distribution and functions of P2 receptor subtypes in different systems. Int Rev Cytol 240:31–304 · DOI · Paper page
- Burrell HE, Bowler WB, Gallagher JA, Sharpe GR (2003) Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors. J Invest Dermatol 120:440–447 · DOI
- Buscher R, Hoerning A, Patel HH, Zhang S, Arthur DB, Grasemann H, Ratjen F, Insel PA (2006) P2Y2 receptor polymorphisms and haplotypes in cystic fibrosis and their impact on Ca2+ influx. Pharmacogenet Genomics 16:199–205 · doi:10.1097/01.fpc.0000189798.11468.6a
- Buvinic S, Briones R, Huidobro-Toro JP (2002) P2Y1 and P2Y2 receptors are coupled to the NO/cGMP pathway to vasodilate the rat arterial mesenteric bed. Br J Pharmacol 136:847–856 · doi:10.1038/sj.bjp.0704789
- Cabello N, Gandia J, Bertarelli DC, Watanabe M, Lluis C, Franco R, Ferre S, Lujan R, Ciruela F (2009) Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher-order oligomers in living cells. J Neurochem 109:1497–1507 · DOI · Paper page
- Cabrini G, Falzoni S, Forchap SL, Pellegatti P, Balboni A, Agostini P, Cuneo A, Castoldi G, Baricordi OR, Di Virgilio F (2005) A His-155 to Tyr polymorphism confers gain-of-function to the human P2X7 receptor of human leukemic lymphocytes. J Immunol 175:82–89 · DOI · Paper page
- Camaioni E, Boyer JL, Mohanram A, Harden TK, Jacobson KA (1998) Deoxyadenosine bisphosphate derivatives as potent antagonists at P2Y1 receptors. J Med Chem 41:183–190 · doi:10.1021/jm970433l
- Camden JM, Schrader AM, Camden RE, Gonzalez FA, Erb L, Seye CI, Weisman GA (2005) P2Y2 nucleotide receptors enhance α-secretase-dependent amyloid precursor protein processing. J Biol Chem 280:18696–18702 · DOI
- Canals M, Marcellino D, Fanelli F, Ciruela F, de Benedetti P, Goldberg SR, Neve K, Fuxe K, Agnati LF, Woods AS, Ferre S, Lluis C, Bouvier M, Franco R (2003) Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer. J Biol Chem 278:46741–46749 · DOI · Paper page
- Canals M, Burgueno J, Marcellino D, Cabello N, Canela EI, Mallol J, Agnati L, Ferre S, Bouvier M, Fuxe K, Ciruela F, Lluis C, Franco R (2004) Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer. J Neurochem 88:726–734 · DOI · Paper page
- Cankurtaran-Sayar S, Sayar K, Ugur M (2009) P2X7 receptor activates multiple selective dye-permeation pathways in RAW 264.7 and human embryonic kidney 293 cells. Mol Pharmacol 76:1323–1332 · DOI
- Cannon CP, Husted S, Harrington RA, Scirica BM, Emanuelsson H, Peters G, Storey RF (2007) Safety, tolerability, and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, compared with clopidogrel, in patients with non-ST-segment elevation acute coronary syndrome: primary results of the DISPERSE-2 trial. J Am Coll Cardiol 50:1844–1851 · DOI · Paper page
- Cantagrel V, Lossi AM, Boulanger S, Depetris D, Mattei MG, Gecz J, Schwartz CE, Van Maldergem L, Villard L (2004) Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males. J Med Genet 41:736–742 · DOI
- Cantrell AR, Catterall WA (2001) Neuromodulation of Na+ channels: an unexpected form of cellular plasticity. Nat Rev Neurosci 2:397–407 · DOI · Paper page
- Cao L, Broomhead HE, Young MT, North RA (2009) Polar residues in the second transmembrane domain of the rat P2X2 receptor that affect spontaneous gating, unitary conductance, and rectification. J Neurosci 29:14257–14264 · DOI
- Capra V, Ravasi S, Accomazzo MR, Citro S, Grimoldi M, Abbracchio MP, Rovati GE (2005) CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation. J Cell Sci 118:5625–5636 · DOI
- Cario-Toumaniantz C, Loirand G, Ladoux A, Pacaud P (1998) P2X7 receptor activation-induced contraction and lysis in human saphenous vein smooth muscle. Circ Res 83:196–203 · DOI
- Carpenter D, Meadows HJ, Brough S, Chapman G, Clarke C, Coldwell M, Davis R, Harrison D, Meakin J, McHale M, Rice SQ, Tomlinson WJ, Wood M, Sanger GJ (1999) Site-specific splice variation of the human P2X4 receptor. Neurosci Lett 273:183–186 · DOI
- Carriba P, Ortiz O, Patkar K, Justinova Z, Stroik J, Themann A, Muller C, Woods AS, Hope BT, Ciruela F, Casado V, Canela EI, Lluis C, Goldberg SR, Moratalla R, Franco R, Ferre S (2007) Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids. Neuropsychopharmacology 32:2249–2259 · DOI · Paper page
- Carter RL, Fricks IP, Barrett MO, Burianek LE, Zhou Y, Ko H, Das A, Jacobson KA, Lazarowski ER, Harden TK (2009) Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor. Mol Pharmacol 76:1341–1348 · DOI
- Cattaneo M (2005) The P2 receptors and congenital platelet function defects. Semin Thromb Hemost 31:168–173 · doi:10.1055/s-2005-869522
- Cattaneo M (2010) New P2Y12 inhibitors. Circulation 121:171–179 · DOI · Paper page
- Cattaneo M, Lecchi A, Randi AM, McGregor JL, Mannucci PM (1992) Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate. Blood 80:2787–2796 · doi:10.1182/blood.v80.11.2787.2787
- Cattaneo M, Lombardi R, Zighetti ML, Gachet C, Ohlmann P, Cazenave JP, Mannucci PM (1997) Deficiency of (33P)2MeS-ADP binding sites on platelets with secretion defect, normal granule stores and normal thromboxane A2 production. Evidence that ADP potentiates platelet secretion independently of the formation of large platelet aggregates and thromboxane A2 production. Thromb Haemost 77:986–990 · doi:10.1055/s-0038-1656090
- Cattaneo M, Zighetti ML, Lombardi R, Martinez C, Lecchi A, Conley PB, Ware J, Ruggeri ZM (2003) Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding. Proc Natl Acad Sci U S A 100:1978–1983 · DOI · Paper page
- Cattaneo M, Lecchi A, Ohno M, Joshi BV, Besada P, Tchilibon S, Lombardi R, Bischofberger N, Harden TK, Jacobson KA (2004) Antiaggregatory activity in human platelets of potent antagonists of the P2Y1 receptor. Biochem Pharmacol 68:1995–2002 · doi:10.1016/j.bcp.2004.06.026
- Centemeri C, Bolego C, Abbracchio MP, Cattabeni F, Puglisi L, Burnstock G, Nicosia S (1997) Characterization of the Ca2+ responses evoked by ATP and other nucleotides in mammalian brain astrocytes. Br J Pharmacol 121:1700–1706 · DOI
- Ceruti S, Villa G, Genovese T, Mazzon E, Longhi R, Rosa P, Bramanti P, Cuzzocrea S, Abbracchio MP (2009) The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury. Brain 132:2206–2218 · DOI
- Ceruti S, Vigano F, Boda E, Ferrario S, Magni G, Boccazzi M, Rosa P, Buffo A, Abbracchio MP (2011) Expression of the new P2Y-like receptor GPR17 during oligodendrocyte precursor cell maturation regulates sensitivity to ATP-induced death. Glia 59:363–378 · DOI
- Chabre M, le Maire M (2005) Monomeric G-protein-coupled receptor as a functional unit. Biochemistry 44:9395–9403 · DOI · Paper page
- Chambers JK, Macdonald LE, Sarau HM, Ames RS, Freeman K, Foley JJ, Zhu Y, McLaughlin MM, Murdock P, McMillan L, Trill J, Swift A, Aiyar N, Taylor P, Vawter L, Naheed S, Szekeres P, Hervieu G, Scott C, Watson JM, Murphy AJ, Duzic E, Klein C, Bergsma DJ, Wilson S, Livi GP (2000) A G protein-coupled receptor for UDP-glucose. J Biol Chem 275:10767–10771 · DOI · Paper page
- Chang K, Hanaoka K, Kumada M, Takuwa Y (1995) Molecular cloning and functional analysis of a novel P2 nucleotide receptor. J Biol Chem 270:26152–26158 · DOI · Paper page
- Charlton SJ, Brown CA, Weisman GA, Turner JT, Erb L, Boarder MR (1996) PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors. Br J Pharmacol 118:704–710 · DOI
- Charlton ME, Williams AS, Fogliano M, Sweetnam PM, Duman RS (1997) The isolation and characterization of a novel G protein-coupled receptor regulated by immunologic challenge. Brain Res 764:141–148 · doi:10.1016/s0006-8993(97)00438-1
- Chaumont S, Khakh BS (2008) Patch-clamp coordinated spectroscopy shows P2X2 receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channels. Proc Natl Acad Sci U S A 105:12063–12068 · DOI
- Chaumont S, Compan V, Toulme E, Richler E, Housley GD, Rassendren F, Khakh BS (2008) Regulation of P2X2 receptors by the neuronal calcium sensor VILIP1. Sci Signal. 1, ra8 · DOI
- Chen BC, Lin WW (2001) PKC- and ERK-dependent activation of I kappa B kinase by lipopolysaccharide in macrophages: enhancement by P2Y receptor-mediated CaMK activation. Br J Pharmacol 134:1055–1065 · DOI
- Chen CC, Akopian AN, Sivilotti L, Colquhoun D, Burnstock G, Wood JN (1995) A P2X purinoceptor expressed by a subset of sensory neurons. Nature 377:428–431 · DOI · Paper page
- Chen ZP, Krull N, Xu S, Levy A, Lightman SL (1996) Molecular cloning and functional characterization of a rat pituitary G protein-coupled adenosine triphosphate (ATP) receptor. Endocrinology 137:1833–1840 · doi:10.1210/en.137.5.1833
- Chen C, Parker MS, Barnes AP, Deininger P, Bobbin RP (2000) Functional expression of three P2X2 receptor splice variants from guinea pig cochlea. J Neurophysiol 83:1502–1509 · doi:10.1152/jn.2000.83.3.1502
- Chen D, Wang W, Guo W, Yu Q, Burnstock G, He C, Xiang Z, Zheng H (2011) Expression of P2Y6 receptors in the developing mouse skeletal muscle and after injury and repair. J Anat 218:643–651 · DOI
- Cheng AW, Kong LW, Tung EK, Siow NL, Choi RC, Zhu SQ, Peng BH, Tsim KW (2003) cDNA encodes Xenopus P2Y1 nucleotide receptor: expression at the neuromuscular junctions. Neuroreport 14:351–357 · doi:10.1097/00001756-200303030-00011
- Chessell IP, Michel AD, Humphrey PP (1998a) Effects of antagonists at the human recombinant P2X7 receptor. Br J Pharmacol 124:1314–1320 · DOI · Paper page
- Chessell IP, Simon J, Hibell AD, Michel AD, Barnard EA, Humphrey PP (1998b) Cloning and functional characterisation of the mouse P2X7 receptor. FEBS Lett 439:26–30 · DOI
- Cheung KK, Ryten M, Burnstock G (2003) Abundant and dynamic expression of G protein-coupled P2Y receptors in mammalian development. Dev Dyn 228:254–266 · DOI
- Chhatriwala M, Ravi RG, Patel RI, Boyer JL, Jacobson KA, Harden TK (2004) Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog. J Pharmacol Exp Ther 311:1038–1043 · DOI
- Chiu J, DeSalle R, Lam HM, Meisel L, Coruzzi G (1999) Molecular evolution of glutamate receptors: a primitive signaling mechanism that existed before plants and animals diverged. Mol Biol Evol 16:826–838 · DOI · Paper page
- Choi RC, Man ML, Ling KK, Ip NY, Simon J, Barnard EA, Tsim KW (2001) Expression of the P2Y1 nucleotide receptor in chick muscle: its functional role in the regulation of acetylcholinesterase and acetylcholine receptor. J Neurosci 21:9224–9234 · DOI
- Choi RC, Siow NL, Cheng AW, Ling KK, Tung EK, Simon J, Barnard EA, Tsim KW (2003) ATP acts via P2Y1 receptors to stimulate acetylcholinesterase and acetylcholine receptor expression: transduction and transcription control. J Neurosci 23:4445–4456 · DOI
- Choi RC, Wong CSS, Simon J, Barnard EA (2005a) Agonist-induced homo-dimerisation of P2Y1 receptors demonstated by fluorescence resonance energy transfer analysis. Br J Pharmacol 146:11P
- Choi RC, Wong CSS, Simon J, Barnard EA (2005b) Roles of the C-terminal domain in signal transduction, dimerisation, desensitisation and internalisation of the P2Y1 receptor. Br J Pharmacol 146:C005
- Choi RC, Simon J, Tsim KW, Barnard EA (2008) Constitutive and agonist-induced dimerizations of the P2Y1 receptor: relationship to internalization and scaffolding. J Biol Chem 283:11050–11063 · doi:10.1074/jbc.m709266200
- Chorna NE, Santiago-Perez LI, Erb L, Seye CI, Neary JT, Sun GY, Weisman GA, Gonzalez FA (2004) P2Y receptors activate neuroprotective mechanisms in astrocytic cells. J Neurochem 91:119–132 · DOI
- Ciana P, Fumagalli M, Trincavelli ML, Verderio C, Rosa P, Lecca D, Ferrario S, Parravicini C, Capra V, Gelosa P, Guerrini U, Belcredito S, Cimino M, Sironi L, Tremoli E, Rovati GE, Martini C, Abbracchio MP (2006) The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J 25:4615–4627 · DOI · Paper page
- Ciruela F, Casado V, Mallol J, Canela EI, Lluis C, Franco R (1995) Immunological identification of A1 adenosine receptors in brain cortex. J Neurosci Res 42:818–828 · doi:10.1002/jnr.490420610
- Ciruela F, Casado V, Rodrigues RJ, Lujan R, Burgueno J, Canals M, Borycz J, Rebola N, Goldberg SR, Mallol J, Cortes A, Canela EI, Lopez-Gimenez JF, Milligan G, Lluis C, Cunha RA, Ferre S, Franco R (2006) Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1–A2A receptor heteromers. J Neurosci 26:2080–2087 · DOI · Paper page
- Clark G, Roux SJ (2009) Extracellular nucleotides: Ancient signaling molecules. Plant Science 177:239–244 · DOI
- Clarke LL, Boucher RC (1992) Chloride secretory response to extracellular ATP in human normal and cystic fibrosis nasal epithelia. Am J Physiol 263:C348–356 · DOI
- Clarke LL, Harline MC, Otero MA, Glover GG, Garrad RC, Krugh B, Walker NM, Gonzalez FA, Turner JT, Weisman GA (1999) Desensitization of P2Y2 receptor-activated transepithelial anion secretion. Am J Physiol 276:C777–C787 · doi:10.1152/ajpcell.1999.276.4.c777
- Clarke CE, Benham CD, Bridges A, George AR, Meadows HJ (2000a) Mutation of histidine 286 of the human P2X4 purinoceptor removes extracellular pH sensitivity. J Physiol 523(Pt 3):697–703 · DOI
- Clarke LL, Harline MC, Gawenis LR, Walker NM, Turner JT, Weisman GA (2000b) Extracellular UTP stimulates electrogenic bicarbonate secretion across CFTR knockout gallbladder epithelium. Am J Physiol Gastrointest Liver Physiol 279:G132–G138 · doi:10.1152/ajpgi.2000.279.1.g132
- Clifford EE, Parker K, Humphreys BD, Kertesy SB, Dubyak GR (1998) The P2X1 receptor, an adenosine triphosphate-gated cation channel, is expressed in human platelets but not in human blood leukocytes. Blood 91:3172–3181 · DOI
- Clyne JD, LaPointe LD, Hume RI (2002) The role of histidine residues in modulation of the rat P2X2 purinoceptor by zinc and pH. J Physiol 539:347–359 · DOI
- Cockcroft S, Gomperts BD (1979) ATP induces nucleotide permeability in rat mast cells. Nature 279:541–542 · DOI
- Cockcroft S, Gomperts BD (1980) The ATP4- receptor of rat mast cells. Biochem J 188:789–798 · DOI · Paper page
- Coddou C, Morales B, Gonzalez J, Grauso M, Gordillo F, Bull P, Rassendren F, Huidobro-Toro JP (2003) Histidine 140 plays a key role in the inhibitory modulation of the P2X4 nucleotide receptor by copper but not zinc. J Biol Chem 278:36777–36785 · DOI
- Coddou C, Acuna-Castillo C, Bull P, Huidobro-Toro JP (2007) Dissecting the facilitator and inhibitor allosteric metal sites of the P2X4 receptor channel: critical roles of CYS132 for zinc potentiation and ASP138 for copper inhibition. J Biol Chem 282:36879–36886 · doi:10.1074/jbc.m706925200
- Coddou C, Codocedo JF, Li S, Lillo JG, Acuna-Castillo C, Bull P, Stojilkovic SS, Huidobro-Toro JP (2009) Reactive oxygen species potentiate the P2X2 receptor activity through intracellular Cys430. J Neurosci 29:12284–12291 · DOI
- Coddou C, Yan Z, Obsil T, Huidobro-Toro JP, Stojilkovic SS (2011) Activation and regulation of purinergic P2X receptor channels. Pharmacol Rev 63:641–683 · DOI · Paper page
- Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G (1996) Cloning of P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J Neurosci 16:2495–2507 · DOI · Paper page
- Communi D, Marteau F, Ben Addi A, Suarez Gonzalez N, Robaye B, Boeynaems J-M (2005a) Nucleotide receptor P2Y13. AfCS-Nature Molecule Pages ID A000700 · doi:10.1038/mp.a000700.01
- Communi D, Robaye B, oeynaems J-M (2005b) Nucleotide receptor P2Y4. AfCS-Nature Molecule Pages. ID A001691 · doi:10.1038/mp.a001691.01
- Communi D, Pirotton S, Parmentier M, Boeynaems JM (1995) Cloning and functional expression of a human uridine nucleotide receptor. J Biol Chem 270:30849–30852 · DOI
- Communi D, Motte S, Boeynaems JM, Pirotton S (1996a) Pharmacological characterization of the human P2Y4 receptor. Eur J Pharmacol 317:383–389 · DOI · Paper page
- Communi D, Parmentier M, Boeynaems JM (1996b) Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem Biophys Res Commun 222:303–308 · DOI · Paper page
- Communi D, Govaerts C, Parmentier M, Boeynaems JM (1997) Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase. J Biol Chem 272:31969–31973 · DOI · Paper page
- Communi D, Paindavoine P, Place GA, Parmentier M, Boeynaems JM (1999a) Expression of P2Y receptors in cell lines derived from the human lung. Br J Pharmacol 127:562–568 · doi:10.1038/sj.bjp.0702560
- Communi D, Robaye B, Boeynaems JM (1999b) Pharmacological characterization of the human P2Y11 receptor. Br J Pharmacol 128:1199–1206 · DOI · Paper page
- Communi D, Janssens R, Robaye B, Zeelis N, Boeynaems JM (2000) Rapid up-regulation of P2Y messengers during granulocytic differentiation of HL-60 cells. FEBS Lett 475:39–42 · DOI
- Communi D, Gonzalez NS, Detheux M, Brezillon S, Lannoy V, Parmentier M, Boeynaems JM (2001a) Identification of a novel human ADP receptor coupled to Gi. J Biol Chem 276:41479–41485 · DOI · Paper page
- Communi D, Suarez-Huerta N, Dussossoy D, Savi P, Boeynaems JM (2001b) Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes. J Biol Chem 276:16561–16566 · doi:10.1074/jbc.m009609200
- Compan V, Ulmann L, Stelmashenko O, Chemin J, Chaumont S, Rassendren F (2012) P2X2 and P2X5 subunits define a new heteromeric receptor with P2X7-like properties. J Neurosci 32:4284–4296 · DOI
- Conigrave AD, Lee JY, van der Weyden L, Jiang L, Ward P, Tasevski V, Luttrell BM, Morris MB (1998) Pharmacological profile of a novel cyclic AMP-linked P2 receptor on undifferentiated HL-60 leukemia cells. Br J Pharmacol 124:1580–1585 · doi:10.1038/sj.bjp.0701985
- Conigrave AD, Fernando KC, Gu B, Tasevski V, Zhang W, Luttrell BM, Wiley JS (2001) P2Y11 receptor expression by human lymphocytes: evidence for two cAMP-linked purinoceptors. Eur J Pharmacol 426:157–163 · DOI
- Conley PB, Delaney SM (2003) Scientific and therapeutic insights into the role of the platelet P2Y12 receptor in thrombosis. Curr Opin Hematol 10:333–338 · DOI
- Cook SP, McCleskey EW (1997) Desensitization, recovery and Ca2+-dependent modulation of ATP-gated P2X receptors in nociceptors. Neuropharmacology 36:1303–1308 · DOI
- Cook SP, Rodland KD, McCleskey EW (1998) A memory for extracellular Ca2+ by speeding recovery of P2X receptors from desensitization. J Neurosci 18:9238–9244 · DOI
- Corringer PJ, Baaden M, Bocquet N, Delarue M, Dufresne V, Nury H, Prevost M, Van Renterghem C (2010) Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues. J Physiol 588:565–572 · DOI
- Costa-Junior HM, Sarmento Vieira F, Coutinho-Silva R (2011) C terminus of the P2X7 receptor: treasure hunting. Purinergic Signal 7:7–19 · DOI
- Costanzi S, Mamedova L, Gao ZG, Jacobson KA (2004) Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling. J Med Chem 47:5393–5404 · DOI
- Costanzi S, Tikhonova IG, Ohno M, Roh EJ, Joshi BV, Colson AO, Houston D, Maddileti S, Harden TK, Jacobson KA (2007) P2Y1 antagonists: combining receptor-based modeling and QSAR for a quantitative prediction of the biological activity based on consensus scoring. J Med Chem 50:3229–3241 · doi:10.1021/jm0700971
- Coutinho-Silva R, Persechini PM (1997) P2Z purinoceptor-associated pores induced by extracellular ATP in macrophages and J774 cells. Am J Physiol 273:C1793–C1800 · DOI
- Coutinho-Silva R, Parsons M, Robson T, Lincoln J, Burnstock G (2003a) P2X and P2Y purinoceptor expression in pancreas from streptozotocin-diabetic rats. Mol Cell Endocrinol 204:141–154 · DOI
- Coutinho-Silva R, Stahl L, Raymond MN, Jungas T, Verbeke P, Burnstock G, Darville T, Ojcius DM (2003b) Inhibition of chlamydial infectious activity due to P2X7R-dependent phospholipase D activation. Immunity 19:403–412 · DOI
- Cox MA, Gomes B, Palmer K, Du K, Wiekowski M, Wilburn B, Petro M, Chou CC, Desquitado C, Schwarz M, Lunn C, Lundell D, Narula SK, Zavodny PJ, Jenh CH (2005) The pyrimidinergic P2Y6 receptor mediates a novel release of proinflammatory cytokines and chemokines in monocytic cells stimulated with UDP. Biochem Biophys Res Commun 330:467–473 · DOI
- Cressman VL, Lazarowski E, Homolya L, Boucher RC, Koller BH, Grubb BR (1999) Effect of loss of P2Y2 receptor gene expression on nucleotide regulation of murine epithelial Cl- transport. J Biol Chem 274:26461–26468 · DOI · Paper page
- Cristalli G, Podda GM, Costanzi S, Lambertucci C, Lecchi A, Vittori S, Volpini R, Zighetti ML, Cattaneo M (2005) Effects of 5′-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors. J Med Chem 48:2763–2766 · doi:10.1021/jm0493562
- Dahlquist R, Diamant B (1974) Interaction of ATP and calcium on the rat mast cell: effect on histamine release. Acta Pharmacol Toxicol (Copenh) 34:368–384 · DOI
- Daly ME, Dawood BB, Lester WA, Peake IR, Rodeghiero F, Goodeve AC, Makris M, Wilde JT, Mumford AD, Watson SP, Mundell SJ (2009) Identification and characterization of a novel P2Y12 variant in a patient diagnosed with type 1 von Willebrand disease in the European MCMDM-1VWD study. Blood 113:4110–4113 · doi:10.1182/blood-2008-11-190850
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Metadata
- Authors
- Burnstock, G., & Verkhratsky, A.
- Venue
- Purinergic Signalling and the Nervous System
- Publisher
- Springer Berlin Heidelberg
- Published
- 2012
- Volume
- 50
- Issue
- 3
- Pages
- 119-244
- OpenAlex
- W2099757747
- Cited by
- 3,958
- References
- 10
- FWCI
- 60.70
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- www.springernature.com/gp/researchers/text-and-data-mining (tdm)
- www.springernature.com/gp/researchers/text-and-data-mining (vor)
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