Evaluation of the Neuroprotective Effect of Microglial Depletion by CSF-1R Inhibition in a Parkinson’s Animal Model

Oh, Se Jong; Ahn, Heesu; Jung, Ki-Hye; Han, Sang Jin; Nam, Kyung Rok; Kang, Kyung Jun; Park, Ji-Ae; Lee, Kyo Chul; Lee, Yong Jin; Choi, Jae Yong

doi:10.1007/s11307-020-01485-w

Evaluation of the Neuroprotective Effect of Microglial Depletion by CSF-1R Inhibition in a Parkinson’s Animal Model

Purpose Neuroinflammation in Parkinson's disease (PD) is known to play a pivotal role in progression to neuronal degeneration. It has been reported that colony-stimulation factor 1 receptor (CSF-1R) inhibition can effectively deplete microglia. However, its therapeutic efficacy in PD is unclear s…