Obstructive sleep apnea symptoms beyond sleepiness and snoring: effects of nasal APAP therapy
Abstract
Objective The purpose of this study was to evaluate the prevalence and assess the response to nasal automatic positive airway pressure (APAP) therapy of less typical symptoms in patients diagnosed with obstructive sleep apnea (OSA), like fatigue, gasping, nocturia, nocturnal sweating, morning headaches, heartburn, and erectile dysfunction.Methods Ninety-eight male patients with moderate to severe OSA were included in the study (n = 98). In the beginning of the study, an overnight sleep study was performed to all subjects using a five-channel recording device. Patients started APAP therapy with pre-determined minimum and maximum pressures of 4 and 15 cmH(2)0, respectively. The total Sleep Disorders Questionnaire was answered by all subjects before and 6 months after APAP therapy. Questions 4, 18, 23, 25, 58, 88, and 148 were used in this study. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) 17.0 software.Results Subjects had a mean (SD) age of 55.1 (10.8) years and an average of 52.2 (21.4) apnea-hypopnea events per hour of sleep. At baseline, nocturia was the most prevalent symptom (38%), followed by nocturnal sweating (34%), gasping (30%), erectile dysfunction (25%), fatigue (23%), heartburn (15%), and morning headaches (10%). After 6 months of APAP therapy, a statistically significant reduction on the prevalence of all symptoms was observed, except for erectile dysfunction and morning headaches.Conclusion The findings suggest that APAP therapy is effective in controlling the majority of OSA symptoms beyond sleepiness and snoring.
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Sleep apnoea often presents as daytime sleepiness or non-restorative sleep and sometimes as insomnia.
“sleep apnoea often presents as daytime sleepiness or non-restorative sleep (Alam et al., 2012; Cruz et al., 2012; Lal et al., 2012; Lee et al., 2012; Sunwoo et al., 2012) and sometimes as insomnia (Al-Jawder & Bahammam, 2012; Glidewell et al., 2012).”
From Addressing sleep disturbances: an opportunity to prevent cardiometabolic disease? (2014) · cites this paper as Cruz et al., 2012
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References 44 · Cited by 50
- Authors
- Cruz, I. A. C., Drummond, M., & Winck, J. C.
- Affiliations
- Universidade do Porto (PT)
- Corresponding author
- Winck, João C.
- Venue
- Sleep and Breathing
- Published
- 2011-03-02
- Volume
- 16
- Issue
- 2
- Pages
- 361-366
- ISSN
- 1520-9512 (ISSN-L)
- 1522-1709
- OpenAlex
- W2035968958
- Cited by
- 50
- References
- 44
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 4 · 2015: 8 · 2014: 6 · 2013: 7 · 2012: 7
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Sleep And Breathing (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Keywords
- obstructive sleep apnea, automatic positive airway pressure, CPAP therapy, nocturia, night sweats, gasping, fatigue, heartburn, erectile dysfunction, morning headache, symptom prevalence, treatment response
- MeSH terms
- Adult, Aged, Follow-Up Studies, Humans, Disorders of Excessive Somnolence, Male, Middle Aged, Quality of Life, Surveys and Questionnaires, Snoring, Therapy, Computer-Assisted, Polysomnography, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure
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