Mediterranean diet reduces senescence-associated stress in endothelial cells
Open accessAbstract
This paper aims to study the effects of the oxidative stress induced by quality and quantity of dietary fat on cellular senescence. Twenty elderly subjects consumed three diets, each for 4 weeks: a saturated fatty acid diet (SFA), a low-fat and high-carbohydrate diet (CHO-ALA), and a Mediterranean diet (MedDiet) enriched in monounsaturated fatty acid following a randomized crossover design. For each diet, we investigated intracellular reactive oxidative species (ROS), cellular apoptosis and telomere length in human umbilical endothelial cells incubated with serum from each patient. MedDiet induced lower intracellular ROS production, cellular apoptosis, and percentage of cell with telomere shortening, compared with the baseline and with SFA and CHO-ALA diets. Dietary fat modulates the oxidative stress in human endothelial cells. MedDiet protects these cells from oxidative stress, prevents cellular senescence and reduces cellular apoptosis.
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Adherence to the Mediterranean diet is significantly associated with lower levels of oxidative stress.
“Studies have demonstrated that adherence to the Mediterranean diet is significantly associated with lower levels of oxidative stress [41,42].”
From Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) · cites this paper as [42]
Consumption of the Mediterranean diet is able to prevent cellular senescence in human epithelial cells.
“Furthermore, it has been shown that consumption of the Mediterranean diet is able to prevent cellular senescence in human epithelial cells [42].”
From Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) · cites this paper as [42]
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References 22 · Cited by 96
- Authors
- Marin, C., Delgado-Lista, J., Ramirez, R., Carracedo, J., Caballero, J., Perez-Martinez, P., Gutierrez-Mariscal, F. M., Garcia-Rios, A., Delgado-Casado, N., Cruz-Teno, C., Yubero-Serrano, E. M., Tinahones, F., Malagon, M. D. M., Perez-Jimenez, F., & Lopez-Miranda, J.
- Affiliations
- Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
- Instituto de Salud Carlos III (ES)
- Venue
- AGE
- Published
- 2011-09-06
- Volume
- 34
- Issue
- 6
- Pages
- 1309-1316
- ISSN
- 0161-9152 (ISSN-L)
- 1574-4647
- PMC
- PMC3528364
- OpenAlex
- W1999080957
- Cited by
- 96
- References
- 22
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 8 · 2022: 7 · 2021: 8 · 2020: 5 · 2019: 11 · 2018: 12 · 2017: 4 · 2016: 5 · 2015: 9 · 2014: 5 · 2013: 7 · 2012: 1
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- AGE (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerio de Ciencia e Innovación (AGL2006‐01979, AGL2004–07907, FIS PI10/01041, PI10/01041, AGL2009–12270)
- Junta de Andalucía (PI-JA0235/2009, JA0235/2009)
- Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
- Instituto de Salud Carlos III (PI10/01041, PS09/00836, PI08/1038, I3SNS)
- European Regional Development Fund
- Fundación Pública Andaluza Progreso y Salud
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- Mediterranean diet, cellular senescence, oxidative stress, endothelial cells, reactive oxygen species, apoptosis, telomere length, dietary fat, monounsaturated fatty acids, saturated fatty acids, high-carbohydrate diet
- MeSH terms
- Aged, Aging, Dietary Carbohydrates, Fatty Acids, Unsaturated, Female, Humans, Male, Fatty Acids, Omega-3, Cellular Senescence, Apoptosis, Reactive Oxygen Species, Oxidative Stress, Cross-Over Studies, Diet, Fat-Restricted, Diet, Mediterranean, Diet, High-Fat, Telomere Homeostasis, Human Umbilical Vein Endothelial Cells
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