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Cited by 592biodegradable polymer synthesis and propertiesHydrogels: synthesis, properties, applicationsBone Tissue Engineering Materials

Synthetic biodegradable functional polymers for tissue engineering: a brief review

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Guo, BaoLin, Ma, Peter X.·2014·Science China Chemistry
DOI 10.1007/s11426-014-5086-yPMC PMC4341840
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Abstract

Scaffolds play a crucial role in tissue engineering. Biodegradable polymers with great processing flexibility are the predominant scaffolding materials. Synthetic biodegradable polymers with well-defined structure and without immunological concerns associated with naturally derived polymers are widely used in tissue engineering. The synthetic biodegradable polymers that are widely used in tissue engineering, including polyesters, polyanhydrides, polyphosphazenes, polyurethane, and poly (glycerol sebacate) are summarized in this article. New developments in conducting polymers, photoresponsive polymers, amino-acid-based polymers, enzymatically degradable polymers, and peptide-activated polymers are also discussed. In addition to chemical functionalization, the scaffold designs that mimic the nano and micro features of the extracellular matrix (ECM) are presented as well, and composite and nanocomposite scaffolds are also reviewed.

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  • Fossil-based polymers usually have a controlled structure, no immunological reaction, and a higher degree of processing flexibility.

    “They usually have a controlled structure, no immunological reaction, and a higher degree of processing flexibility. They can also provide better control over the synthesis and design of the polymer itself [11].”

    From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [11]

    Section 2.1 says synthetic polymers usually have controlled structure, greater processing flexibility, and no immunological concerns. It does not identify them specifically as fossil-based polymers, and ‘no immunological concerns’ does not establish that they cause no immunological reaction. The paper also discusses control over polymer properties through synthesis and design, but not as a comparative advantage of fossil-based polymers. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Fossil-based polymers can provide better control over the synthesis and design of the polymer itself.

    “They usually have a controlled structure, no immunological reaction, and a higher degree of processing flexibility. They can also provide better control over the synthesis and design of the polymer itself [11].”

    From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [11]

    Section 2.1 describes synthetic polymers as having controlled structures and explains that their composition and properties can be tuned, supporting the point about control over polymer design. It does not identify these polymers as fossil-based or establish that the advantage applies specifically to fossil-based polymers. Page numbers are unavailable in our copy. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • Some synthetic biodegradable polymers have attracted considerable attention because they present high biocompatibility, ease of processing, and tailored mechanical properties and degradation rates.

    “some synthetic biodegradable polymers have attracted considerable attention over the past decades since the present high biocompatibility, ease of processing, as well as tailored mechanical properties and degradation rates [21][22][23][24][25][26]”

    From A strategy to tailor the mechanical and degradation properties of PCL-PEG-PCL based copolymers for biomedical application (2023) · cites this paper as [21]

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Cited by

Sorted by citations

Authors
Guo, B., & Ma, P. X.
Affiliations
  • Xi'an Jiaotong University (CN)
  • University of Michigan (US)
Corresponding author
Ma, Peter X.
ORCID
Venue
Science China Chemistry
Publisher
Springer Science and Business Media LLC
Published
2014-03-01
Volume
57
Issue
4
Pages
490-500
ISSN
  • 1001-652X (ISSN-L)
  • 1674-7291
  • 1869-1870
DOI
10.1007/s11426-014-5086-y
PMC
PMC4341840
OpenAlex
W2252957247
Cited by
592
References
6
Citations by year
2026: 25 · 2025: 53 · 2024: 54 · 2023: 65 · 2022: 70 · 2021: 68 · 2020: 73 · 2019: 56 · 2018: 39 · 2017: 45 · 2016: 20 · 2015: 19 · 2014: 4
FWCI
11.12
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Science China Chemistry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Dental and Craniofacial Research (R01DE017689, R01DE022327, R01DE015384)
Topics
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords
tissue engineering scaffolds, polyesters, polyanhydrides, polyphosphazenes, polyurethane, polyglycolic acid, conducting polymers, photoresponsive polymers, amino acid-based polymers, chemical functionalization, extracellular matrix mimicry, nanocomposite scaffolds, composite scaffolds

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