Autoantibody to MOG suggests two distinct clinical subtypes of NMOSD
Open accessAbstract
We characterized a unique group of patients with neuromyelitis optica spectrum disorder (NMOSD) who carried autoantibodies of aquaporin-4 (AQP4) and myelin-oligodendrocyte glycoprotein (MOG). Among the 125 NMOSD patients, 10 (8.0%) were AQP4- and MOG-ab double positive, and 14 (11.2%) were MOG-ab single positive. The double-positive patients had a multiphase disease course with a high annual relapse rate (P=0.0431), and severe residual disability (P>0.0001). Of the double- positive patients, 70% had MS-like brain lesions, more severe edematous, multifocal regions on spinal magnetic resonance imaging (MRI), pronounced decreases of retinal nerve fiber layer thickness and atrophy of optic nerves. In contrast, patients with only MOG-ab had a higher ratio of monophasic disease course and mild residual disability. Spinal cord MRI illustrated multifocal cord lesions with mild edema, and brain MRIs showed more lesions around lateral ventricles. NMOSD patients carrying both autoantibodies to AQP4 and MOG existed and exhibited combined features of prototypic NMO and relapsing- remitting form of MS, whereas NMOSD with antibodies to MOG only exhibited an "intermediate" phenotype between NMOSD and MS. Our study suggests that antibodies against MOG might be pathogenic in NMOSD patients and that determination of anti-MOG antibodies maybe instructive for management of NMOSD patients.
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Cites
Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria
Polman, C. H., Reingold, S. C., Banwell, B., Clanet, M., Cohen, J. A., Filippi, M., Fujihara, K., Havrdova, E., Hutchinson, M., Kappos, L., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22366 · Cited by 9,802 · see citing works
New Multiple Sclerosis Phenotypic Classification
LUBLIN, F. D. (2014) · European Neurology · doi:10.1159/000367614 · Cited by 4,277 · see citing works
IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
Lennon, V. A., Kryzer, T. J., Pittock, S. J., Verkman, A. S., & Hinson, S. R. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050304 · Cited by 2,288 · see citing works
The spectrum of neuromyelitis optica
Wingerchuk, D. M., Lennon, V. A., Lucchinetti, C. F., Pittock, S. J., & Weinshenker, B. G. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70216-8 · Cited by 2,182 · see citing works
Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders
Sato, D. K., Callegaro, D., Lana-Peixoto, M. A., Waters, P. J., Jorge, F. M. D. H., Takahashi, T., Nakashima, I., Apostolos-Pereira, S. L., Talim, N., Simm, R. F., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000101 · Cited by 850 · see citing works
Jarius, S., Ruprecht, K., Wildemann, B., Kümpfel, T., Ringelstein, M., Geis, C., Kleiter, I., Kleinschnitz, C., Berthele, A., Brettschneider, J., et al. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-14 · Cited by 762 · see citing works
Dale, R. C. (2000) · Brain · doi:10.1093/brain/123.12.2407 · Cited by 703 · see citing works
Brain Abnormalities in Neuromyelitis Optica
Pittock, S. J., Lennon, V. A., Krecke, K. N., Wingerchuk, D. M., Lucchinetti, C. F., & Weinshenker, B. G. (2006) · Archives of Neurology · doi:10.1001/archneur.63.3.390 · Cited by 677 · see citing works
Berger, T., Rubner, P., Schautzer, F., Egg, R., Ulmer, H., Mayringer, I., Dilitz, E., Deisenhammer, F., & Reindl, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022328 · Cited by 617 · see citing works
Kitley, J., Waters, P., Woodhall, M., Leite, M. I., Murchison, A., George, J., Küker, W., Chandratre, S., Vincent, A., & Palace, J. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2013.5857 · Cited by 597 · see citing works
Aquaporin 4 and neuromyelitis optica
Papadopoulos, M., & Verkman, A. S. (2012) · Lancet Neurology · doi:10.1016/s1474-4422(12)70133-3 · Cited by 574 · see citing works
Saadoun, S., Waters, P., Bell, B., Vincent, A., Verkman, A., & Papadopoulos, M. (2010) · Brain : a journal of neurology · doi:10.1093/brain/awp309 · Cited by 574 · see citing works
Serologic diagnosis of NMO: A multicenter comparison of aquaporin-4-IgG assays
Waters, P. J., McKeon, A., Leite, M. I., Rajasekharan, S., Lennon, V. A., Villalobos, A., Palace, J., Mandrekar, J. N., Vincent, A., Bar-Or, A., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e318248dec1 · Cited by 526 · see citing works
Mader, S., Gredler, V., Schanda, K., Rostasy, K. M., Dujmović, I., Pfaller, K., Lutterotti, A., Jarius, S., Pauli, F. D., Kuenz, B., et al. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-184 · Cited by 449 · see citing works
Myelin-oligodendrocyte glycoprotein antibodies in adults with a neuromyelitis optica phenotype
Kitley, J., Woodhall, M., Waters, P., Leite, M. I., Devenney, E., Craig, J., Palace, J., & Vincent, A. (2012) · Neurology · doi:10.1212/wnl.0b013e31826aac4e · Cited by 445 · see citing works
The spectrum of MOG autoantibody-associated demyelinating diseases
Reindl, M., Pauli, F. D., Rostasy, K. M., & Berger, T. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.118 · Cited by 373 · see citing works
Bettelli, E., Baeten, D., Jäger, A., Sobel, R. A., & Kuchroo, V. K. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28334 · Cited by 336 · see citing works
Lack of Association between Antimyelin Antibodies and Progression to Multiple Sclerosis
Kühle, J., Pohl, C., Mehling, M., Edan, G., Freedman, M. S., Hartung, H., Polman, C. H., Miller, D. H., Montalbán, X., Barkhof, F., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063602 · Cited by 256 · see citing works
Zhou, D., Srivastava, R., Nessler, S., Grummel, V., Sommer, N., Brück, W., Hartung, H., Stadelmann, C., & Hemmer, B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607242103 · Cited by 231 · see citing works
Distinction of seropositive NMO spectrum disorder and MS brain lesion distribution
Matthews, L., Marasco, R., Jenkinson, M., Küker, W., Luppe, S., Leite, M. I., Giorgio, A., De Stefano, N., Robertson, N., Johansen-Berg, H., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e3182887957 · Cited by 225 · see citing works
Anti-MOG antibodies are present in a subgroup of patients with a neuromyelitis optica phenotype
Pröbstel, A., Rudolf, G., Dornmair, K., Collongues, N., Chanson, J., Sanderson, N., Lindberg, R. L. P., Kappos, L., Seze, J. D., & Derfuss, T. J. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0256-1 · Cited by 169 · see citing works
Rostasy, K. M., Mader, S., Hennes, E. M., Schanda, K., Gredler, V., Guenther, A., Blaschek, A., Korenke, C., Pritsch, M., Pohl, D., et al. (2012) · Multiple Sclerosis Journal · doi:10.1177/1352458512470310 · Cited by 154 · see citing works
Marta, C. B., Oliver, A. R., Sweet, R. A., Pfeiffer, S. E., & Ruddle, N. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504979102 · Cited by 152 · see citing works
Neuromyelitis optica MOG-IgG causes reversible lesions in mouse brain
Saadoun, S., Waters, P. J., Owens, G. P., Bennett, J. L., Vincent, A. C., & Papadopoulos, M. C. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-35 · Cited by 137 · see citing works
Self-citationLongitudinally Extensive Transverse Myelitis With and Without Aquaporin 4 Antibodies
Kitley, J., Leite, M. I., Küker, W., et al. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.3890 · Cited by 120 · see citing works
Neuromyelitis optica IgG and natural killer cells produce NMO lesions in mice without myelin loss
Ratelade, J., Zhang, H., Saadoun, S., Bennett, J. L., Papadopoulos, M. C., & Verkman, A. S. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0986-4 · Cited by 106 · see citing works
Self-citationRelationship Between NMO-Antibody and Anti–MOG Antibody in Optic Neuritis
Kezuka, T., Usui, Y., Yamakawa, N., Matsunaga, Y., Matsuda, R., Masuda, M., Utsumi, H., Tanaka, K., & Gotô, H. (2011) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0b013e31823c9b6c · Cited by 68 · see citing works
Anti-MOG antibodies in adult patients with demyelinating disorders of the central nervous system
Tanaka, M., & Tanaka, K. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.03.001 · Cited by 59 · see citing works
Aquaporin 4 IgG Serostatus and Outcome in Recurrent Longitudinally Extensive Transverse Myelitis
Jiao, Y.-J., Fryer, J., Lennon, V., McKeon, A., Jenkins, S. M., Smith, C. Y., Quek, A., Weinshenker, B., Wingerchuk, D., Shuster, E., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2013.5055 · Cited by 58 · see citing works
Magnetic resonance imaging in neuromyelitis optica
Tackley, G. W., Küker, W., & Palace, J. A. (2014) · Multiple Sclerosis Journal · doi:10.1177/1352458514531087 · Cited by 55 · see citing works
Acute Disseminating Encephalomyelitis in Neuromyelitis Optica
Eichel, R., Meiner, Z., Abramsky, O., et al. (2008) · Archives of Neurology · doi:10.1001/archneurol.2007.59 · Cited by 46 · see citing works
Woodhall, M. R., Çoban, A., Waters, P. J., et al. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.08.034 · Cited by 37 · see citing works
The two faces of neuromyelitis optica
Weinshenker, B. G., & Wingerchuk, D. M. (2014) · Neurology · doi:10.1212/wnl.0000000000000114 · Cited by 25 · see citing works
Granieri, L., Marnetto, F., Valentino, P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038896 · Cited by 22 · see citing works
Liu, J., Yeung, P. K. K., Cheng, L., Lo, A., Chung, S. S. M., & Chung, S. K. (2015) · Science China Life Sciences · doi:10.1007/s11427-015-4860-1 · Cited by 16 · see citing works
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- Authors
- Yan, Y., Li, Y., Fu, Y., Yang, L., Su, L., Shi, K., Li, M., Liu, Q., Borazanci, A., Liu, Y., He, Y., Bennett, J. L., Vollmer, T. L., & Shi, F.-D.
- Affiliations
- Tianjin Medical University General Hospital (CN)
- Barrow Neurological Institute (US)
- University of Colorado Anschutz (US)
- Corresponding author
- Yan, Yaping
- Shi, Fu-Dong
- ORCID
- Venue
- Science China Life Sciences
- Published
- 2016-02-26
- Volume
- 59
- Issue
- 12
- Pages
- 1270-1281
- ISSN
- 1674-7305 (ISSN-L)
- 1869-1889
- PMC
- PMC5101174
- OpenAlex
- W2286801180
- Cited by
- 63
- References
- 35
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 9 · 2021: 5 · 2020: 8 · 2019: 7 · 2018: 6 · 2017: 6 · 2016: 3
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Science China Life Sciences (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion, cc-by)
- PubMed Central (acceptedVersion, cc-by)
- Funders
- American Heart Association
- National Natural Science Foundation of China (81230028, 81371372, 81100888)
- National Key Research and Development Program of China
- National Eye Institute (R01EY022936)
- National Institute of Allergy and Infectious Diseases (R01AI083294)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Keywords
- neuromyelitis optica spectrum disorder, aquaporin-4 antibodies, clinical subtypes, relapse rate, residual disability, optic atrophy, retinal nerve fiber layer thickness, brain lesions, spinal cord lesions, clinical course
- MeSH terms
- Adolescent, Adult, Autoantibodies, Brain, Female, Humans, Immunologic Factors, Magnetic Resonance Imaging, Male, Middle Aged, Neuromyelitis Optica, Optic Nerve, Pilot Projects, Recurrence, Retinal Ganglion Cells, Retrospective Studies, Spinal Cord, Tomography, Optical Coherence, Aquaporin 4, HEK293 Cells, Myelin-Oligodendrocyte Glycoprotein
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