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Synapse Loss Induced by Interleukin-1β Requires Pre- and Post-synaptic Mechanisms
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IL-1β has complex effects on neurons including disruption of synaptic plasticity, promotion of excitotoxicity, and modulation of α- and γ-secretase activities while reducing β-secretase activity and Aβ levels.
“shows complex and divers effects on neurons including disruption of synaptic plasticity [21], promotion of excitotoxicity [22, 23] and α- and γ-secretase activities, while reducing β-secretase activity [24, 25] and Aβ levels [26, 27].”
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“Thus, synapse loss may underlie the protective actions of IL-1β (Carlson et al. 1999) whereas sustained, strong activation of NMDA receptors may contribute to the toxic effects of IL-1β (Allan et al. 2005).”
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Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
Leng, F., & Edison, P. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-020-00435-y · Cited by 3,179
Walker, W. H., Borniger, J. C., Gaudier-Diaz, M. M., Hecmarie Meléndez-Fernández, O., Pascoe, J. L., Courtney DeVries, A., & Nelson, R. J. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0430-4 · Cited by 129
Principles of inflammasome priming and inhibition: implications for psychiatric disorders
Herman, F. J., & Pasinetti, G. M. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.06.010 · Cited by 115
Biomarkers of post-covid depression
Lorkiewicz, P., & Waszkiewicz, N. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10184142 · Cited by 102
Kamila, P., Kar, K., Chowdhury, S., Chakraborty, P., Dutta, R., S, S., Singh S, A., & Prajapati, B. G. (2025) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2025.05.005 · Cited by 90
Pilat, D., Paumier, J.-M., García-González, L., Louis, L., Stephan, D., Manrique, C., Khrestchatisky, M., Di Pasquale, E., Baranger, K., & Rivera, S. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02407-z · Cited by 28
Singh, R., Rai, S., Bharti, P. S., Zehra, S., Gorai, P. K., Modi, G. P., Rani, N., Dev, K., Inampudi, K. K., Y., V. V., et al. (2024) · BMC Medicine · doi:10.1186/s12916-024-03475-z · Cited by 28
Metadata
- Authors
- Mishra, A., Kim, H. J., Shin, A. H., & Thayer, S. A.
- Venue
- Journal of Neuroimmune Pharmacology
- Published
- 2012-02-05
- Volume
- 7
- Issue
- 3
- Pages
- 571-578
- ISSN
- 1557-1890
- 1557-1904
- PMC
- PMC3415563
- Cited by
- 121
- References
- 1
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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