Interleukin-1 and neuronal injury

Allan, Stuart M.; Tyrrell, Pippa J.; Rothwell, Nancy J.

doi:10.1038/nri1664

Cited by 992Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersTraumatic Brain Injury and Neurovascular Disturbances

Interleukin-1 and neuronal injury

Allan, Stuart M., Tyrrell, Pippa J., Rothwell, Nancy J.·2005·Nature Reviews Immunology

DOI 10.1038/nri1664

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Abstract

Interleukin-1 is a pro-inflammatory cytokine that has numerous biological effects, including activation of many inflammatory processes (through activation of T cells, for example), induction of expression of acute-phase proteins, an important function in neuroimmune responses and direct effects on the brain itself. There is now extensive evidence to support the direct involvement of interleukin-1 in the neuronal injury that occurs in both acute and chronic neurodegenerative disorders. This article discusses the key evidence of a role for interleukin-1 in acute neurodegeneration - for example, stroke and brain trauma - and provides a rationale for targeting the interleukin-1 system as a therapeutic strategy.

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Microglia may promote neurodegeneration by producing proinflammatory or potentially neurotoxic effectors, including IL-1β, NO, or ROS.
“but they may also promote neurodegeneration by producing proinflammatory or potentially neurotoxic effectors, including interleukin-1␤ (IL-1␤), nitric oxide (NO⅐), or reactive oxygen species (ROS) (Allan et al., 2005;Block et al., 2007;Hanisch and Kettenmann, 2007).”
From Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase (2008) · cites this paper as Allan et al., 2005

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Authors: Allan, S. M., Tyrrell, P. J., & Rothwell, N. J.
Affiliations: University of Manchester (GB)
Salford Royal Hospital (GB)
Corresponding author: Allan, Stuart M.
ORCID: Allan, Stuart M.
Tyrrell, Pippa J.
Rothwell, Nancy J.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2005-07-20
Volume: 5
Issue: 8
Pages: 629-640
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri1664
OpenAlex: W1978525572
Cited by: 992
References: 3
Citations by year: 2026: 28 · 2025: 28 · 2024: 33 · 2023: 36 · 2022: 37 · 2021: 43 · 2020: 43 · 2019: 39 · 2018: 46 · 2017: 53 · 2016: 50 · 2015: 54 · 2014: 67 · 2013: 61 · 2012: 61
FWCI: 4.63
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: interleukin-1, neuronal injury, neuroinflammation, neurodegeneration, stroke, traumatic brain injury, neuroimmune response, acute phase proteins, T cell activation, neuroprotection
MeSH terms: Animals, Central Nervous System, Humans, Interleukin-1, Neurons, Neurodegenerative Diseases

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Interleukin-1 and neuronal injury

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