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Cited by 38Schizophrenia research and treatmentAdvanced Neuroimaging Techniques and ApplicationsNeural and Behavioral Psychology Studies

Relationship between white matter integrity, attention, and memory in schizophrenia: a diffusion tensor imaging study

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Kubicki, M., Niznikiewicz, M., Connor, E., Ungar, L., Nestor, P. G., Bouix, S., Dreusicke, M., Kikinis, R. +2 more·2009·Brain Imaging and Behavior
DOI 10.1007/s11682-009-9061-8PMC PMC2885800
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Abstract

Attention and memory deficits are among the most prominent cognitive disturbances observed in schizophrenia. It has been suggested that a disruption in anatomical connectivity between areas involved in attentional control might be responsible for these abnormalities. We used Diffusion Tensor Tractography and Color Stroop/Negative Priming(NP) paradigm to investigate integrity of Cingulum Bundle(CB), the main white matter tract interconnecting these regions, and its relationship with executive functions in patients with schizophrenia and matched controls. The Fractional Anisotropy(FA), was calculated along the CB pathways, and correlated with reaction times for each Stroop item, and both Stroop, and NP effects. Patients with schizophrenia demonstrated decreased CB integrity and diminished NP effect, compared with controls, but both groups showed Stroop effect. For patients only, reaction times for every item, as well as for Stroop effect, correlated with left CB FA. These findings suggest that CB integrity disruptions might compromise the executive processes in schizophrenia.

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  • Cingulum FA correlations with executive function are more consistent in schizophrenia than in ASD.

    “Arguably, more consistent cingulum FA correlations with executive function have been found in schizophrenia (Kubicki et al., 2009; Spalletta et al., 2014; Takei et al., 2009; see Table 2).”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Kubicki et al., 2009

    The Results (Correlation analyses) report significant correlations between left cingulum FA and Stroop reaction times and the Stroop effect in patients with schizophrenia. The paper compares those patients with healthy controls, not people with ASD, so it does not establish that the correlations are more consistent in schizophrenia than in ASD. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Correlations between executive functions and cingulum white matter properties have been reported in depression, bipolar disorder, and schizophrenia.

    “This overall pattern is continued in clinical brain imaging studies as correlations between executive functions and cingulum white matter properties have been reported in depression (with DTI in Schermuly et al., 2010), in bipolar disorder (with DTI in Poletti et al., 2015; with Positron Emission Tomography in Li et al., 2012), and schizophrenia (with DTI in Kubicki et al., 2009; Takei et al., 200”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Kubicki et al., 2009

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Authors
Kubicki, M., Niznikiewicz, M., Connor, E., Ungar, L., Nestor, P. G., Bouix, S., Dreusicke, M., Kikinis, R., McCarley, R. W., & Shenton, M. E.
Affiliations
  • Brigham and Women's Hospital (US)
  • Harvard University (US)
Corresponding author
Kubicki, M.
ORCID
Venue
Brain Imaging and Behavior
Publisher
Springer Science and Business Media LLC
Published
2009-03-13
Volume
3
Issue
2
Pages
191-201
ISSN
  • 1931-7557 (ISSN-L)
  • 1931-7565
DOI
10.1007/s11682-009-9061-8
PMC
PMC2885800
OpenAlex
W2064688911
Cited by
38
References
4
Citations by year
2025: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 1 · 2013: 3 · 2012: 3
FWCI
1.03
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Brain Imaging and Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Espace ÉTS (ETS) (submittedVersion)
Funders
  • U.S. Department of Veterans Affairs
  • National Institutes of Health
  • National Institute of Mental Health (R03MH068464)
  • National Institute of Biomedical Imaging and Bioengineering (U54EB005149)
  • National Center for Research Resources (P41RR013218)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
schizophrenia, white matter integrity, cingulum, attention deficits, memory impairment, executive function, Stroop interference, negative priming, fractional anisotropy, structural connectivity, reaction time

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